The Catalase (CAT) gene is associated with the synthesis of catalase, an enzyme found to be associated with the conversion of superoxide (O2-) into oxygen (O2) and hydrogen peroxide (H2O2). It is a heme enzyme and is present in the peroxisome of almost all aerobic cells.
Superoxide is formed in the body as a byproduct of oxygen metabolism and it can result in damage to the cell. Catalase is one of the important antioxidant enzymes in the body. People with the T variant of the gene are shown to be associated with lower catalase activity.
Association with Antioxidant needs:
In a study conducted on people with prostate cancer, people with the T variant of the gene were shown to be associated with advanced stages of the disease when compared to people with the C variant of the gene. The rare variant (T) is found to be associated with lower catalase activity which may lead to deficient antioxidant protection against oxidative stress, potentially increasing the risk of disease.
Does your 23andme, Ancestry DNA, FTDNA raw data have CAT gene variant information?
| CHIP Version | CAT SNPs |
| 23andMe (Use your 23andme raw data to know your CAT Variant) | |
| v1 23andme | Present |
| v2 23andme | Present |
| v3 23andme | Present |
| v4 23andme | Present |
| V5 23andme (current chip) | Present |
| AncestryDNA (Use your ancestry DNA raw data to know your CAT Variant) | |
| v1 ancestry DNA | Present |
| V2 ancestry DNA (current chip) | Present |
| Family Tree DNA (Use your FTDNA raw data to know your CAT Variant) | |
| OmniExpress microarray chip | Present |
Genotypers1001179 |
Phenotype |
Recommendation |
| CC |
[Advantage] More likely to have higher antioxidant activity [Advantage] More likely to have lower risk for diseases |
|
| CT | Moderate antioxidant activity |
|
| TT |
[Limitation] More likely to lower antioxidant activity [Advantage] More likely to have higher risk for diseases |
References:
- http://cebp.aacrjournals.org/content/24/1/178
- http://cebp.aacrjournals.org/content/24/1/178
- https://www.ncbi.nlm.nih.gov/pubmed/16775184
- https://www.ncbi.nlm.nih.gov/gene/847
- https://en.wikipedia.org/wiki/Catalase
Related Links:
- https://www.xcode.life/uncategorized/antioxidants-armed-soldiers-hidden-in-your-diet
- https://www.xcode.life/dna-and-nutrition/are-antioxidants-more-important-for-people-carrying-certain-genes
“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”
