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If it’s been a while since you mailed out your sample from the 23andMe DNA kit, and you’re wondering when you’ll receive your results, you’re not alone. While their website mentions an average 4-6 week timeline, some users report getting their results as early as 10 days after 23andMe receives their sample. So, then, how long does 23andMe take? This article will inform you about the various steps involved in the analysis process, possible delays, and how fast most consumers receive their DNA analysis results.

About 23andMe

23andMe is a company that provides direct-to-consumer genetic/DNA testing and analysis.

The company has over 12.5 million customers worldwide

Its primary service is a direct-to-consumer genetic test based on saliva samples.

This test includes information about customers’ ancestry, health, and traits. 

Recently, the company has come under fire due to its handling of customer data and privacy concerns.

23andMe Process and Timeline: What to Expect

There are multiple steps between registering on 23andMe and receiving your results.

  1. Create a 23andMe account on the website and order a kit
  2. Send the sample back to the lab, after which they:
    • Prepare your sample
    • Extract the DNA from your sample
    • Genotype the sample
    • Review the DNA data
    • Perform the final computation
    • Upload the results to your account. 

Your homepage keeps you informed about each step of the process.

It shows what stage your sample is on and estimates the date of result delivery.

How Long Does 23andMe Take? The image shows the timeline of 23andMe process right from a user registering for a DNA kit to them receiving their results.
Image adapted from 23andMe website

Timeline for 23andMe Results: How Long Will You Wait?

Once your kit is received at the lab, you should receive your results in 4-6 weeks.

Samples mailed from within the United States can take anywhere between 2-4 weeks to reach the lab.

Once you mail your DNA sample back, it can take up to 10 weeks to receive your results. However, many customers report receiving the results much earlier.

These times are estimates.

The company cannot guarantee that you will receive the reports on the date mentioned.

Over the past two years, 23andMe’s wait time seems to have remained under 25-30 days, which is sufficiently quick.

Why Does 23andMe Processing Take Longer Than Expected

Several factors can impact the time it takes to get your results:

  1. The time it takes to receive the kit upon registering
  2. The time it takes for you to ship the kit back
  3. The shipping time
  4. The processing time at the lab
  5. The report generation time

Certain samples may require additional steps to be processed successfully, which can further increase the wait time.



How Long Does It Take To Get Results From 23andMe UK?

The saliva collection kit is generally dispatched within 1 to 2 business days. 

They also offer express shipping at a premium if required.

Once you mail them your unique kit barcode, your reports will be prepared.

In approximately 3 to 4 weeks, once they are ready, an email will inform you that your reports can be accessed in your online account.

AncestryDNA vs. 23andMe: Which Is Faster?

AncestryDNA and 23andMe are two of the most popular DNA analysis companies.

The former has a much bigger database with 18 million users, while the latter has 12 million users.

This could mean that the accuracy of the former is higher than the latter.

According to the AncestryDNA website, “it can take up to 5 weeks from the date you mail in a sample for the laboratory to mark it as arrived, and 8 weeks from the date we receive your sample for your results to be ready.”This means that 23andMe processes your report much quicker (by a couple of weeks to a month) than AncestryDNA.

What Do You Get With The 23andMe Services?

The information in your report depends on the services you have chosen.

23andMe offers four kinds of personal genetic services.

  1. Ancestry
  2. Health + Ancestry
  3. 23andMe+ Premium
  4. 23andMe+ Total Health
ServiceDescriptionPrice
Ancestry Ancestry breakdown and 30+ trait reports– 80+ personalized reports– Ancestry percentages (to the 0.1%)– 2750+ geographic regions$99
Health + AncestryEverything in Ancestry service +– 150+ personalized reports– FDA-authorized reports– FSA/HSA eligibility$199
23andMe+ PremiumEverything in Health + Ancestry service +– Heart health and personalized medicine reports– Health tracker– Health action plan– Historical Matches (new feature)$199 for the first year, $69/yr after
23andMe+ Total HealthEverything in 23andMe+ Premium +– Next-generation exome sequencing– Biannual blood testing– Access to clinicians $999 for the first year, $499/yr after 

What Other Information Can I Get?

With the information present in your DNA data, you can uncover insights into several aspects of your health and well-being.

Update: Accessing 23andMe DNA Data Amidst The Controversy

An important part of your 23andMe result is the DNA data, which you can easily access and download from your account. 

Your DNA data provides a massive amount of information that you can use to unlock thousands of insights beyond 23andMe.

Preview of what your 23andMe raw data looks like

Recently, a hacker advertised that they had stolen millions of “pieces of data,” breaking into the DNA relatives feature that allowed the users to compare ancestry information with users worldwide.

While 23andMe is looking into this and attempting to solve it, they have indefinitely blocked the download of DNA data as a security measure. Here’s how you can submit a request to access your DNA data.

To get your DNA raw data, follow the instructions from this page:

How to download your 23andMe Raw Data for 700+ Health Reports



Summary of 23andMe Processing Times

Frequently Asked Questions

Will 23andMe Tell Me Who My Father Is?

23andMe cannot determine biological parentage.

The site’s ethnicity service helps link users to their genetic relatives.

Can 23andMe DNA Test Be Wrong?

The company claims an accuracy rate of more than 99% for its BRCA test.

Despite this, the test could produce false positive or negative results.

How Far Back Does 23andMe Go?

Their ancestry test traces your lineage back 8 generations.

Beyond eight generations, it’s hard to track your DNA accurately.


Others Are Also Reading

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AncestryDNA vs 23andMe: Which Is Better For Raw Data Analysis?

MyHeritage

MyHeritage vs 23andMe: Detailed Review and Comparison


Many health experts suggest that magnesium is a prevalent deficiency in the population, but it is also lesser known. However, thanks to the buzz created by TikTok influencers, it's gaining the attention it deserves. While many are aware of magnesium, few know the full extent of its health benefits. This article delves into why magnesium is essential for the body and highlights the top 7 most significant benefits of magnesium for men's health.

Important Functions Of Magnesium In The Body

Magnesium is a vital mineral that plays numerous roles in maintaining overall health. Despite its importance, many people do not consume enough magnesium in their diets. Here are some of the key functions of magnesium in the body:

Infographic showing the different benefits of magnesium for men

7 Evidence-based Magnesium Benefits For Men

1. Testosterone Balance

In males with low testosterone levels, magnesium can help bring it to optimum levels.

It plays both a direct role and an indirect role by converting vitamin D to its active form, which is required for testosterone production.

Studies suggest that low testosterone (the primary male sex hormone) in older men may be a predictor of type II diabetes and early mortality.

A 2011 study reports magnesium supplements may help improve testosterone production in older adults and decrease the risk of metabolic conditions like diabetes.

2. Heart Health

Magnesium is key to a healthy heart as it influences neuron signaling and heart muscle contractions.

It also regulates the movement of electrolytes like calcium and potassium into the cells.

A 2013 meta-analysis compared the results of 16 independent studies.

It reports that people with increased circulating magnesium levels had up to a 30% lower risk of developing cardiovascular diseases

The study further reports that high dietary magnesium levels helped reduce the risk of ischemic heart diseases by up to 22%.

3. Better Sleep

Though the mechanism behind this is unclear, it is hypothesized that magnesium helps with relaxation by acting on certain brain chemicals.

It also may bring down cortisol levels and increase melatonin.

All these can promote better sleep. 

A 2012 placebo-controlled clinical trial analyzed the effects of magnesium supplementation on sleep disorders like insomnia and early awakening in older adults. 

According to this study, magnesium supplementation helped improve sleep by increasing serotonin and melatonin levels.

4. Physical Performance 

Magnesium improves muscle functions and enhances workouts by increasing the glucose availability in the blood.

A 2011 study reports magnesium supplementation can help improve performance strengths in athletes, aiding better handgrip, rotation, and jumping performance. 

Working out or physical exercise depletes magnesium levels in the body.

If this is not compensated with dietary or supplementary magnesium, it may affect physical performance.

5. Exercise Recovery

Men who work out regularly always have the risk of post-workout injuries and muscle aches.

Magnesium helps improve muscle flexibility, decreasing the risk of post-workout injuries.

Low magnesium levels in the body may encourage lactic acid buildup in the muscles.

This can lead to muscle aches, burning, and nausea. Improving magnesium hence helps with better exercise recovery.

6. Mental Health

According to Mental Health America, about six million American men are affected by depression yearly.

Depression, bipolar disorder, anxiety, psychosis, schizophrenia, and eating disorders are some of the top mental health issues men face in the country.

Studies report magnesium deficiency can lead to various psychiatric symptoms, including depression. 

7. Bone Health

Magnesium affects bone health in men in two ways.


Did you know that certain genes like CASR can increase the risk of magnesium deficiency even when on a nutritionally optimal diet? Get your Gene Nutrition report to understand your nutritional needs.*


Magnesium Deficiency In Men

Magnesium deficiency, also known as hypomagnesemia, occurs when the body does not receive enough magnesium to support its essential functions. 

Although rare in healthy individuals, certain conditions can lead to inadequate magnesium levels. 

Causes And Risk Factors

Symptoms

Magnesium deficiency doesn’t cause significant symptoms immediately. However, chronic magnesium deficiency may lead to the following symptoms.

Men with chronic magnesium deficiency may have a higher risk of developing high blood pressure, type 2 diabetes, and heart diseases

Infographic highlighting the causes, risk factors and symptoms of magnesium deficiency. These are followed by a list of good magnesium sources and the recommended dietary allowance (RDA) of magnesium.

Magnesium: Consumption Guide

The recommended daily intake of magnesium

AgeMaleFemalePregnancyLactation
Birth to 6 months30 mg*30 mg*
7–12 months75 mg*75 mg*
1–3 years80 mg80 mg
4–8 years130 mg130 mg
9–13 years240 mg240 mg
14–18 years410 mg360 mg400 mg360 mg
19–30 years400 mg310 mg350 mg310 mg
31–50 years420 mg320 mg360 mg320 mg
51+ years420 mg320 mg

Source: https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/

Sources Of Magnesium

The following are some of the best magnesium-rich foods.

Depending on the source, tap water or bottled water can also contain traces of magnesium.

You can also increase your magnesium intake daily by choosing magnesium-fortified foods. 

Risks Of Overconsumption

While magnesium is essential for numerous bodily functions, overconsumption can lead to serious health issues. 

Understanding the risks associated with excessive magnesium intake is crucial, particularly for those considering supplements.

Effects of Overconsumption

Magnesium Supplementation: Things To Keep In Mind

It is always safe to consult a medical practitioner before starting magnesium supplementation.

Depending on your health status and some other factors, your doctor can recommend a suitable form of magnesium.

Some forms of magnesium supplements with better absorption are:

Interactions with Medications

Magnesium can interact with various medications, including:

Consultation is key

Discuss any current medications with your healthcare provider before starting magnesium supplements to avoid potential interactions.

Is 500mg Of Magnesium A Day Too Much?

The maximum recommended dosage for males is 420 mg/day and females 350 mg/day.

Anything more than this is considered unsafe and can lead to the side effects mentioned above.

Should I Take Magnesium In The Morning Or At Night?

Magnesium supplements can be taken at any time of the day; what is important here is to be consistent with it.

If you are taking magnesium to resolve sleep issues, then it is better to consume it before going to bed.

FAQs About Magnesium Benefits For Men

Do Men Over 50 Need Magnesium?

Yes, men over 50 do need magnesium. In fact, males aged 30 and above require more magnesium (420 mg/day) than those who are younger than 30 (400 mg/day).

Magnesium can preserve cognition as you age and also supports muscle functions.

Does Magnesium Help With Erectile Dysfunction?

Studies have established a link between low magnesium levels and increased prevalence of erectile dysfunction.

While further research is needed, it is hypothesized that magnesium may assist with erectile dysfunction in several ways:

Does Magnesium Raise Testosterone?

Multiple studies have shown that magnesium can help increase testosterone levels in magnesium-deficient males.

The effect is much more on those who engage in regular workouts compared to those with a sedentary lifestyle. 

Does Magnesium Increase Blood Flow?

Magnesium is essential for vascular health and can enhance blood flow. It relaxes blood vessels by blocking calcium channels.

It also supports the production of nitric acid, which is required for vasodilation.

Further, magnesium also helps regulate blood pressure, which aids in overall healthy blood flow.

Summary

  1. Magnesium is a vital macro mineral that helps men stay healthy and active.
  2. The proper levels of magnesium help protect heart health, reduce the risk of metabolic conditions, improve sleep, increase testosterone levels, and support mental health.
  3. Magnesium deficiency can cause tiredness and fatigue, muscle contractions, and abnormal heart rhythms, apart from other symptoms.
  4. Nuts and seeds, leafy greens, bananas, beans, and whole wheat flour are good sources of magnesium.
  5. Doctor-recommended magnesium supplements help improve levels safely and get the benefits of this mineral.

References

Could the constant pain or fatigue you're experiencing be more than just passing stress or exhaustion? Chronic conditions like fibromyalgia and MS are becoming increasingly prevalent worldwide, affecting millions of people. Despite their considerable effect on everyday life, these conditions often remain underdiagnosed. Fibromyalgia, for instance, is estimated to affect up to 5% of the global population. At the same time, over 2.8 million people today live with MS. What makes these two conditions so prevalent yet so difficult to diagnose? As gaps in prevalence estimates persist, it's crucial to explore the underlying causes and latest findings about fibromyalgia and MS.

Fibromyalgia vs. MS - An Overview

Fibromyalgia is a long-term health issue that leads to widespread pain across the body.

While the cause remains unknown, many experts believe it may involve abnormal processing of pain signals within the brain and spinal cord.

Due to its persistent nature, this condition often affects musculoskeletal areas and can make daily tasks challenging.

Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammation and harm to the central nervous system (spinal cord).

In this condition, the immune system abnormally attacks the myelin sheath, which protects nerve fibers. This damage interferes with communication between the brain and body, resulting in various symptoms.

MS often develops in young adults, specifically those aged 20 to 40, and can significantly disrupt routine activities.

Fibromyalgia vs. MS - Symptoms

Both conditions can present with similar symptoms, such as fatigue and cognitive difficulties, but each condition has some unique characteristics.

Fibromyalgia symptoms include:

MS symptoms include:

Fibromyalgia Pain - How Does It Feel?

People with fibromyalgia often report a constant ache spread across multiple regions of the body.

This pain can cause muscles to feel sore or strained, even without physical activity. It may range from a light ache to intense, burning, or sharp sensations.

Common experiences include:

The pain typically lasts long, making sleeping or staying active harder.

MS Pain - How Does It Feel?

MS pain can appear in various ways due to nerve damage, triggering sensations without a known cause. People with MS may experience:

The intensity of pain varies.

Depending on the progression of MS, some individuals may experience mild tingling, while others face more severe discomfort.

Fibromyalgia vs. MS - Causes

Multiple causes may contribute to the occurrence of both fibromyalgia and MS.

Internal And External Causes

Fibromyalgia

Internal causes:

External causes:

MS

Internal causes:

External causes:

Fibromyalgia vs. MS - Diagnosis And Treatment

The diagnosis and treatment of fibromyalgia and MS differ in several ways, although both conditions rely heavily on symptom evaluation.

Diagnosis

MS diagnosis typically involves ruling out other conditions through various tests. Doctors often perform an MRI and may also order:

Neurologists who specialize in the nervous system usually diagnose and treat MS.

On the other hand, a fibromyalgia diagnosis is made after the patient experiences widespread pain for more than three months without any identifiable cause.

Rheumatologists or primary care doctors typically manage fibromyalgia cases.

Treatment

For MS, doctors recommend medications to manage symptoms, slow the disease, and aid recovery from flare-ups. Treatment options include:

In fibromyalgia, treatment focuses on symptom management. Doctors may prescribe specific medications approved for the condition, such as:

Both conditions require personalized treatment plans, as medication responses can vary from person to person.

Note: This article is purely informative. Always consult a doctor for proper diagnosis and treatment. Never self-diagnose or treat conditions without medical guidance.

Fibromyalgia vs MS - Are There Any Similarities?

Fibromyalgia and MS share several similarities, particularly in their symptoms and risk factors.

Both conditions can cause fatigue, which causes individuals to feel tired often. Though they affect the body differently, there are notable overlaps in how they may develop.

Some key similarities include:

Frequently Asked Questions

Can MS Cause Itching?

Yes, MS can lead to itching. The condition affects the nerves and can result in dysesthesia, which includes abnormal sensations like itching.

This itching may come and go and occur in various body parts. In some individuals, itching may appear early in the disease, sometimes even before they receive a diagnosis.

Fibromyalgia vs. MS - Life Expectancies

While both of these are chronic conditions, their impacts on life expectancy differ.

Fibromyalgia symptoms are persistent but not life-threatening, and the condition does not shorten lifespan.

In contrast, MS can progress and lead to severe symptoms. As reported by the National Multiple Sclerosis Society, MS may reduce a person's lifespan by about seven years, and severe forms can be life-threatening.

Despite this, the National Institute of Neurological Disorders and Stroke notes that many individuals with MS have a similar life expectancy to those without the disease.

Can An MRI Detect Fibromyalgia?

An MRI test cannot diagnose fibromyalgia, as it typically does not reveal specific signs of the condition.

However, some studies have noted unusual features in MRI scans of individuals with fibromyalgia compared to those without it.

These findings suggest that while MRIs can't definitively detect fibromyalgia, they may show differences that could be relevant to understanding the condition.

Summary: Fibromyalgia vs. MS


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Is Fibromyalgia Hereditary?

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Is Alzheimer's Type 3 Diabetes?


References

https://pmc.ncbi.nlm.nih.gov/articles/PMC9859454

https://pmc.ncbi.nlm.nih.gov/articles/PMC7720355

https://www.niams.nih.gov/health-topics/fibromyalgia

https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis

https://www.healthline.com/health/multiple-sclerosis/multiple-sclerosis-vs-fibromyalgia

https://www.medicalnewstoday.com/articles/323840

https://pmc.ncbi.nlm.nih.gov/articles/PMC9180936

https://www.sciencedirect.com/science/article/abs/pii/S0300483X22003195

https://pmc.ncbi.nlm.nih.gov/articles/PMC6283654

https://www.nih.gov/news-events/nih-research-matters/vitamin-d-levels-predict-multiple-sclerosis-progression

https://pmc.ncbi.nlm.nih.gov/articles/PMC7473606

https://www.neurology.org/doi/10.1212/wnl.0000000000201630

https://www.sciencedirect.com/science/article/abs/pii/S0882401023000645

https://www.webmd.com/multiple-sclerosis/ms-fibromyalgia-differences-similarities

https://www.medicalnewstoday.com/articles/323838

https://www.nationalmssociety.org/What-is-MS/MS-FAQ-s

Healthy eating has changed a lot in 2024—the year’s most popular diets focus on lasting changes instead of promising quick results. Rather than strict food rules and crash diets, we’re choosing eating plans that are easier to follow and introduce healthier eating habits. The most popular diets of 2024 help in various ways- from protecting your heart and brain to managing weight and feeling more energetic. Ready to discover which diet might work best for you? Let's look at the five most successful eating plans of 2024 and what makes them stand out from the rest.

Various 2024 diets have showcased their health benefits and popularity. 

Here are the top five, highlighting their unique advantages along with scores out of 100:

  1. Mediterranean diet
  1. DASH diet (Dietary Approaches to Stop Hypertension)
  1. MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay)
  1. Mayo Clinic diet
  1. Flexitarian diet 

1. The Mediterranean Diet: Benefits, Pros, And Cons

The Mediterranean diet is a balanced, plant-focused approach inspired by traditional foods from Greece, Italy, and Spain.

It prioritizes whole grains, vegetables, legumes, nuts, and healthy fats like extra-virgin olive oil, with lean proteins mostly from fish and poultry.

This diet values food quality and balance over strict rules, making it adaptable and easy to follow.

Benefits:

Pros:

Cons:

2. The DASH Diet: Benefits, Pros, And Cons

The DASH diet aims to help prevent and manage high blood pressure. 

With support from the National Heart, Lung, and Blood Institute, it boosts fiber and essential minerals like calcium, potassium, and magnesium while reducing sodium and unhealthy fats.

This diet prioritizes fruits, vegetables, whole grains, lean proteins, and low-fat dairy while restricting saturated fats and added sugars. 

Sodium intake is capped at around 2,300 milligrams daily for more significant benefits and eventually drops to 1,500 milligrams.

Benefits:

Pros:

Cons:

3. The MIND Diet: Benefits, Pros, And Cons

The MIND diet merges vital elements of the Mediterranean and DASH diets to promote brain health and lessen cognitive decline.

It was created through research funded by the National Institute on Aging and can potentially lower Alzheimer’s risk by focusing on nutrient-rich and brain-protective foods.

Benefits:

Pros:

Cons:

4. The Flexitarian Diet: Benefits, Pros, And Cons

The flexitarian diet combines flexibility with a plant-based approach. 

Known as a "semi-vegetarian" approach, it encourages mainly eating plant foods and occasionally allowing meat.

This approach makes it less restrictive than a purely vegetarian diet.

It provides health benefits linked to plant-based diets without eliminating meat.

Since it lowers meat consumption, many also consider it environment-friendly.

Benefits:

Pros:

Cons:

5. The Mayo Clinic Diet: Benefits, Pros, And Cons

The Mayo Clinic diet is a 12-week program designed to help individuals develop healthier eating habits by focusing on fruits, vegetables, and whole grains.

This diet promotes less calorie-dense foods, enabling you to enjoy larger portions despite a lower calorie intake.

It also features an app for meal planning, food tracking, and group coaching sessions with Mayo Clinic diet experts.

Benefits:

Pros:

Cons:

Which Diet Has The Highest Success Rate?

The Mediterranean diet generally has one of the highest success rates among diets.

It stands out for its overall health benefits, especially in promoting heart health and managing diabetes, while also being effective for weight loss.

This diet helps people stick with it over time by focusing on nutritious foods and allowing for variety in meals.

Which Is The Best Diet For Weight Loss?

The WeightWatchers diet is recognized as one of the best choices for weight loss in 2024, earning a top weight-loss score of 100.

Known for its structured Points system, the program blends calorie control with behavior support and easy-to-use tools like an app, meal planners, and a supportive community.

Research indicates that WeightWatchers users often achieve significant weight loss, with an average of 9.8 pounds lost in the first 12 weeks.

It also offers customized plans for diabetes management and support for those on weight-loss medications, providing flexibility for diverse needs.

Which Is The Best Diet For Heart Health?

The Mediterranean Diet ranks #1 for heart health, with an impressive score of 100 points.

It focuses on plant-based foods, whole grains, and extra-virgin olive oil, with moderate amounts of seafood and lean poultry while limiting red meat.

Research has proven that this diet effectively reduces blood pressure, improves cholesterol, and lowers the risk of heart disease and stroke.

Which Is The Best Diet For Overall Health?

Most experts view the Mediterranean diet as the best for overall health, awarding it 85.1 out of 100.

They praise the diet for its effectiveness in promoting heart health, managing diabetes, and supporting bone and joint health.

Its focus on whole, nutritious foods makes it a sustainable choice for long-term well-being.

Tips To Get Started On A New Diet

When considering a new diet, it's essential to approach the process with a clear plan. Below are some helpful strategies to guide your journey.

Note: Consult a healthcare provider before beginning a new diet, particularly if you have health concerns. Remember, this article is purely informational, and each person's dietary needs and responses can vary.

FAQs

Who Should Go On A Diet?

You might consider going on a diet if:

How Soon Will I Start Seeing Results From My Diet?

The timeline for seeing results from your diet can vary significantly based on your metabolism, starting weight, diet type, and more.

Generally, you may notice changes in your energy levels or mood within a few days.

For effective weight loss, aim for a sustainable rate of half a pound to 2 pounds per week, according to your body composition.

If you lose weight faster than this, it could be due to losing water weight or even muscle mass, which isn't healthy.

Prioritize shedding body fat while preserving muscle mass, which is essential for overall health and metabolic function.

Which Diets Are Considered The Worst In 2024?

Experts rated several diets the worst in 2024 due to being too restrictive or relying on processed foods. Here are the diets that have significant downsides:

The keto diet is also ranked low overall but can aid in quick weight loss. 

However, it may not be sustainable or healthy in the long run.


Others Are Also Reading

A young couple after their 30 minutes exercise following 30 grams of protein consumption as per Gary Brecka's diet

Gary Brecka 30-30-30 Diet: How To Follow, Pros, And Cons

Diagram of anti-inflammatory foods like blueberries, cherries, avocados etc.

The Ultimate Guide To Anti-inflammatory Diet + Food List PDF

A list of foods to eat on a MTHFR mutations diet like leafy greens, eggs, beets, etc.

MTHFR Diet: What To Eat, What To Avoid For MTHFR Mutation


References

https://health.usnews.com/best-diet/best-diets-overall

https://www.forbes.com/health/nutrition/diet/best-diets

https://www.eatingwell.com/best-and-worst-diets-2024-us-news-world-report-8421345

https://www.healthline.com/health-news/these-are-the-best-diets-for-overall-health-in-2024

https://www.nejm.org/doi/full/10.1056/NEJMoa1800389

https://www.bmj.com/content/343/bmj.d6500

Autism is a condition that can appear in any child, even without a history of it in the family. Since there's no cure, managing autism involves therapies and other strategies. The genetics of autism are complex – it's not caused by a single gene from the parents but is likely due to changes in multiple genes. A common concern among parents is whether they could pass on genes associated with autism to their children. Given the complex nature of autism's genetics, providing a clear answer to this question is challenging. This article explores the current understanding of how autism genes are inherited and what this means for parents.

What Is Autism?

Autism is a developmental condition that affects communication and social interaction. 

Some people with autism exhibit symptoms like difficulty in verbal and nonverbal communication, repetitive behaviors, and low social interaction skills. 

People with autism experience challenges in everyday life, including finding employment, interacting with others, and accessing community resources.

It is still unclear why some people develop autism and others do not, but researchers are exploring all possible causes.

Is Autism Genetic?

Although a single gene does not cause autism, there is evidence that genetics play a role in the development of the disorder. 

Studies have found that people with autism are more likely to have relatives who also have autism and that the risk of developing autism increases with the number of relatives who have the disorder. 

Studies have found that some people with autism have a higher-than-average number of genetic markers associated with the disorder. 

However, there is still much to learn about the genetics of autism and how it contributes to the development of the disorder.

Which Parent Carries The Autism Gene?

Due to its lower prevalence in females, autism was always thought to have a maternal inheritance component.

However, emerging research suggests this is not true.

While there's some weak evidence that points towards the rarer autism-associated variants being inherited from the father, no follow-up studies have been able to back this.

In fact, most studies done on the genetics and inheritance of autism suggest that autism can be inherited from either biological parent, and their sex at birth doesn't determine the chances.

Ultimately, autism is a complex condition with 100s of genes involved. 

In a child with autism, it is very challenging to tease apart maternal and paternal genetic contributions.

Even without a family history of mental disorders, autism can occur in a child due to spontaneous mutations.

Genetic tests can help understand the risk for autism, explain the possible causes, and shine a light on optimal management and treatment options. 

Is Autism Inherited from Mother or Father?

In almost 50% of the cases where there’s only one child in the family with autism, the cause appears to be spontaneous mutations.

Spontaneous mutations are genetic mutations that are absent in the parents and siblings of affected children.

Inheritance of autism by spontaneous mutations

Image: Spontaneous mutations

Researchers have long noted that parents of autistic children display some of the traits seen in their children in a much more muted manner

A 2020 study examined the role of familial relationships in explaining similarities in behaviors across family members. 

The study found a relationship between parents and children's behavioral traits, maternal polygenic scores, and broad autism behavior traits in children.

This means that traits in children with autism may take after the mother's subtle autism-like behaviors.

For example, if a mother has issues communicating in a social setting, then her autistic child may have communication difficulties themselves.

On the other hand, a large study based on the analysis of 9,275 whole genomes suggests that fathers may pass down some mutations tied to autism.

The study focused on flanking gene regions where mutations are rare.

The researchers reported that fathers pass down such rare variants twice as much as mothers.

Does Autism Run in Families?/Is Autism Hereditary?

Studies have shown that autism is predominantly a genetic disorder, with 40-80% heritability.

Researchers are still working to identify all of the genes associated with autism.

However, they do know that some genetic mutations can increase your risk of developing autism.

If you have a family member with autism, you should consider talking to your doctor about getting screened for genetic mutations that could put you at higher risk.

Children in families with a history of other mental conditions are also at a higher risk for developing autism

These can include ADHD, schizophrenia, and bipolar disorder.

According to an article on Spectrum News, “Children who have a first-degree relative — a sibling or parent — with a brain condition other than autism have up to 4.7 times the odds of having autism and up to 7.6 times the odds of having both autism and intellectual disability.”

They function a lot better than their male counterparts with the same mutations.

Does Autism Skip A Generation?

Autism can sometimes seem to "skip a generation." This happens because:

So, if autism is not expressed in one generation, it may appear in the next generation due to these inherited mutations. This is why it might look like autism has skipped a generation.

Can A Parent With Autism Have A Child Without Autism?

Yes, a parent with autism can have a child without autism. While having a parent with autism increases the likelihood of a child being on the autism spectrum, it is not a certainty.

Each child's genetic makeup is unique, and the inheritance of autism is complex and not determined by a single gene.

What Are The Main Causes Of Autism?

Despite years of research, the clear cause of autism is still unknown.

However, there are some risk factors that could increase a person's likelihood of developing autism.

Some of them include:

FAQs On Inheritance Of Autism

Is Autism Inherited From The Mother Or Father?

Autism is influenced by multiple genetic factors, which can be inherited from either parent. It’s not exclusive to one parent, as several genes and their interactions contribute to the risk.

Can Normal Parents Have An Autistic Child?

Yes, autism can occur even if neither parent shows signs of it. This is due to complex genetic factors, including spontaneous mutations, which can happen independently of parental traits.

Are You Born With Autism, Or Does It Develop?

Autism is a neurodevelopmental condition present from birth, although its signs may become more apparent as a child grows and their behavior and communication patterns develop.

Who Carries The Gene For Autism?

Both the biological parents can carry genetic variations linked to autism, but carrying these genes does not guarantee a child will have autism. Environmental factors and gene interactions also play a role.


Most common cause of autism

What Is The Most Common Cause Of Autism?

 
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Genetic Testing For Mental Health

 
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Reference 

From glowing skin to better immunity, glutathione plays a significant role in your body. As a supplement, its popularity is skyrocketing due to its antioxidant properties. However, modifying your diet with supplements can be complex. Cutting back on a few lifestyle habits may be the right call to get the most out of your glutathione supplements. From your morning coffee to your glass of wine in the evening, here’s what to avoid when taking glutathione.


Did You Know?

Many aspects of your skin health and aging, including the risk for conditions like adult acne, rosacea, tanning, and the likelihood of premature wrinkles, stretch marks, cellulite, etc., are highly influenced by your genes. You can learn more about your skin using your existing ancestry genetic test DNA data.

Learn More


Glutathione: The King Of Antioxidants?

Glutathione, the ‘king of antioxidants,’ is made up of three kinds of amino acids - glutamic acid, glycine, and cysteine.

Its primary job is to tackle the threat of free radicals.

Free radicals are harmful compounds that build up in your body over time.

Left unchecked, they could cause oxidative damage to your cells.

More often than not, these free radicals build up in the mitochondria.

Antioxidants like glutathione help protect your cells from these free radicals by scavenging them in the mitochondria.

Glutathione’s ability to protect the mitochondria helps fight off autoimmune diseases like lupus that target the mitochondria.

The role of glutathione in the body is as follows:

Due to these varied glutathione benefits, several dieticians, nutritionists, and physicians have only praises for it.

Annie Rubin, a registered dietitian, writes, “Glutathione is the body’s most potent antioxidant molecule and is also known as the Master Antioxidant.

Why Do People Take Glutathione?

While the body usually produces adequate glutathione, stress, poor diet, or a chronic health condition can reduce glutathione levels.

Some people may be born with a change in the GSS gene responsible for producing glutathione synthetase, the enzyme that produces glutathione.

GSS gene mutations can severely decrease glutathione levels, leading to a deficiency disease. The symptoms of glutathione deficiency look like:

Doctors may suggest supplementation if you are low on glutathione.

Along with chemotherapy drugs, it can promote cell repair and flush out toxic substances.

Some studies suggest that higher glutathione can help manage body weight and fat percentage.

Interestingly, some people choose glutathione for its supposed ability to lighten skin tone. 

However, it isn’t effective

Any noticeable change is reversed soon after stopping glutathione.

What Forms Of Glutathione Are Available?

Glutathione is commonly available as:

  1. Reduced glutathione is an active form of glutathione and can effectively neutralize free radicals in the body.
  2. Acetyl glutathione is another form of active glutathione with more bioavailability, meaning your body can absorb it better.  
  3. Liposomal glutathione: Here, the glutathione is encapsulated within a liposome, which helps improve absorption.

Glutathione supplements come in a variety of forms such as capsules, gels, liquid supplements, skin patches, sprays, and IV injections.

The NIH recommends taking 500-1000mg of glutathione daily (oral or liposomal) alongside other nutrient-rich foods to promote healthy glutathione levels in your body.

Remember to speak to your doctor or a licensed nutritionist about the right frequency and dosage of glutathione beforehand.

What To Avoid When Taking Glutathione

To prevent unpleasant side effects or lowered efficiency, here are a few things to avoid when taking glutathione supplements.

Smoking

Smoking is a preventable cause of oxidative damage in the body.

People who smoke regularly have increased levels of cadmium and malondialdehyde in their blood, which can lead to further cell toxicity.

Since glutathione primarily fights off oxidative stress and toxic pollutants, smoking may cancel out the beneficial effects of glutathione.

Alcohol

Excess alcohol consumption can damage the liver, which helps metabolize glutathione.

Like smoking, alcohol consumption also leads to oxidative damage by activating cytochromes and other reactive oxygen species.

The liver metabolizes alcohol to aldehydes, which cause hangovers.

While glutathione can help detoxify the body from aldehydes, this task impairs its overall efficiency in other parts of the body.

Glutathione may not be beneficial to the body if combined with alcohol consumption.

Certain Medications

While there are no specific drug interactions identified for glutathione, this does not mean there aren’t any.

Some experts say that analgesics like aspirin and acetaminophen can strain the liver when metabolized.

This task could deplete the body’s glutathione reserves.

If you are on medications, please talk to your doctor before starting glutathione.

Caffeine

Some studies have shown that moderate caffeine consumption reduces oxidative stress in the body.

However, caffeine consumption may reduce glutathione levels in the body. 

Consuming caffeine and glutathione together may affect glutathione absorption levels and reduce its bioavailability.   

So, to optimize glutathione supplementation, avoid coffee a few hours before or after taking the supplements.

Balancing out moderate coffee consumption with a diet that promotes glutathione levels is the best option.

Aspartame

Aspartame is a popular zero-calorie sweetener used in many foods and beverages to reduce overall sugar and calorie count. 

However, if consumed regularly, it can lead to inflammation in the liver.

This inflammation due to long-term aspartame consumption may decrease reduced and oxidized glutathione levels in the liver. 

Aspartame’s oxidative stress can take a toll on the adrenal gland as well.

Avoiding aspartame when taking glutathione may improve the effectiveness of the antioxidant. 

Food Preservatives

There are two reasons why preservative-laden food and beverages may not benefit those on glutathione supplementation.

  1. Studies report that preservatives like sodium benzoate and sodium metabisulfite reduce glutathione levels in the body.
  2. Preserved, processed foods help improve shelf life but lack essential nutrients to boost natural glutathione levels or improve their bio-absorption. 
An infographic summarizing the benefits, side effects, food sources, and what to avoid when taking glutathione.

Glutathione Side Effects

While regular doses of glutathione are generally well tolerated, high doses may be toxic to the body. 

In rare cases, too much glutathione can cause diarrhea, nausea, vomiting, headaches, or skin rashes.

If you experience any new symptoms while on glutathione, stop taking it and speak to your primary care provider.

Individuals with existing health conditions must consult a doctor before using glutathione supplements. 

Other FAQs On Glutathione

When Should Glutathione Be Avoided?

The effects of glutathione on pregnant or breastfeeding women haven’t been studied well. 

Avoiding the supplement during these phases is better unless a doctor recommends it.

People with severe liver or kidney conditions must exercise caution while using any supplement. 

What Can I Eat With Glutathione?

Some studies report that vitamin E and C levels help raise serum glutathione levels and make it more effective for the body.

Eating foods rich in vitamin E and vitamin C is one way to improve glutathione absorption. 

Selenium, an essential mineral, is needed for the body to absorb and use glutathione. 

Studies report that selenium supplements increased serum glutathione levels in just three months. 

Foods like organ meat, beef, fish, cottage cheese, and brown rice are natural sources of selenium. 

Does Glutathione Affect Menstruation?

It may not be accurate to say that taking glutathione can affect the menstrual cycle.

However, some studies report that taking glutathione while on your period may increase serum estrogen levels during menstrual cycles. 

Estrogen is a beneficial hormone during the fertile periods of the menstrual cycle and plays a role in preparing the body for pregnancy. 

Can I Take Vitamin D Along With Glutathione?

Vitamin D keeps your skeletal and immune systems healthy. You usually get it from the sun, so it could be challenging to maintain healthy vitamin D levels sometimes.

A study found that vitamin D supplementation with glutathione might be beneficial since it increases glutathione peroxidase-1 levels.

Consult a doctor or nutritionist before modifying, starting, or stopping a supplement regimen.

Natural Sources Of Glutathione 

The following are some of the natural sources of glutathione.

Almonds

A 2007 study reports that almond consumption increases serum glutathione levels by up to 16% and reduces DNA damage by up to 29%. 

Almonds also have various other health benefits and are beneficial when eaten regularly.

Turmeric

Turmeric is a yellowish spice used to add color and taste to food. 

Curcumin, a chemical present in turmeric, is an excellent antioxidant.

Studies report that curcumin increases glutathione S-transferase (GST) activity in the liver. 

Avocados

According to a 2017 study, avocado oil may help increase glutathione levels produced in the liver and offer enhanced antioxidant properties. 

Sulfur-rich Foods

Consuming foods rich in sulfur amino acids may help improve glutathione synthesis, according to a 2011 study.

Some foods rich in sulfur amino acids are cruciferous vegetables, turkey, beef, chicken, nuts, legumes, allium vegetables like garlic, onions, leeks, and shallots, and leafy greens.

Milk Thistle

Milk thistle is a natural herb used for its medicinal properties. 

It contains a compound called silymarin, which may help restore glutathione levels in the body and modulate the activities of the enzymes that metabolize glutathione.

Other Tips To Get The Most Out Of Your Glutathione (Safely)

Here are some other tips to help get the maximum effects of glutathione.

  1. Get enough sleep every day as sleep restores glutathione levels in the body naturally.
  2. Regular exercise may help restore glutathione levels and improve antioxidant activities. 
  3. Reduce alcohol consumption and quit smoking when taking glutathione as they lead to excess oxidative stress and reduce the functioning of the supplement. 
  4. A healthy diet provides all the necessary nutrients to boost serum glutathione levels. 
  5. Mindfulness practices can help reduce stress levels and allow the body to metabolize glutathione effectively

Summary: What To Avoid When Taking Glutathione

  1. Glutathione is an antioxidant that helps reduce oxidative damage and improve immunity.
  2. Glutathione supplements are available over-the-counter and may benefit those with glutathione deficiency or lowered immunity.
  3. Alcohol, tobacco, excess caffeine, aspartame, and packed and processed foods may bring down the efficiency of the supplement and must be avoided when taking glutathione.
  4. Some natural sources that can help increase glutathione levels are turmeric, sulfur-rich foods, milk thistle, avocados, and almonds.
  5. In rare cases, glutathione supplementation can cause unpleasant side effects. Please talk to a healthcare provider before starting any new supplement.

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