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MTHFR stands for methylenetetrahydrofolate reductase, the infamous enzyme whose incorrect shape can put you at risk for a long list of conditions.
MTHFR is a very important enzyme that converts folate into a more usable form called methylfolate in each cell of the body. Methylfolate is responsible for the production of two important compounds.
First is a class of biochemicals called neurotransmitters. They are a class of chemicals that help you think, emote, and perform all sorts of physical activities.
Non-functional MTHFR enzyme that results from single nucleotide changes in your DNA will lead to low levels of neurotransmitters that, in turn, have consequences like insomnia, anxiety, depression, and ADHD, among others.
The second important compound that methylfolate helps to make is called S-adenosylmethionine (SAMe).
SAMe helps to regulate more than 200 enzymes in the body.
Without SAMe, your body is predisposed to conditions like infertility, thrombosis, miscarriage, autism, and certain forms of cancer.
An MTHFR genetic test does not require a medical recommendation.
You can simply download your raw DNA data and upload it to a third-party service provider to get your results.
Genetic reports are generated after the analysis of different polymorphisms in the MTHFR gene.
These polymorphisms tell you which variants you carry and if you are homozygous or heterozygous for those variations.
Now that you know the importance of being aware of your MTHFR polymorphisms, let’s compare two popular tools that provide you with your MTHFR status. These two third-party tools provide a comprehensive MTHFR status report from your raw data from companies like 23andme, AncestryDNA, Family Tree DNA (FTDNA), and others.
Genetic Genie test is a DNA raw data analysis from a 23andme ancestry test. The results are free.
The website interprets your DNA raw data for only your methylation and detox profile.
The detox profile looks at gene SNPs of the cytochrome P450 detox enzymes, amongst others.
It is important to look at this specific information because certain genetic polymorphisms have been shown to impair the detoxification of drugs, hormones, environmental toxins, xenobiotics, and more.
The results column indicates whether you have a favorable, unfavorable, or intermediate genotype.
Your result is not determined solely by any single entry but by the cumulative effect of all the genes and variations listed.
Image showing a section of the methylation report from Genetic Genie
To use Genetic Genie, you need to download your raw data file from the 23andMe website and upload it to the website.
Before you upload to the tool to test your MTHFR status, it is advisable to go through the website's privacy policy.
If you want to see a sample of how the test results look, you can download the dummy raw data file available on the website and upload it immediately.
According to the website, the DNA you upload for the free report is not stored anywhere. Further, the data is encrypted with an HTTPS connection.
So, there's little to no risk of DNA data misuse, making Genetic Genie a very safe platform.
However, it is recommended that you read their privacy policy in detail before using their services.
Xcode Life test results are expert-curated from several large and high scientific authority databases, including UK biobank, Clinvar, OMIM, SNPedia, and leading scientific journals, to name a few, to curate the variant annotations.
Once you upload your raw data to Xcode Life, you will get your test results within 24 hours. You can download your test results and take it to your next routine health test check-up.
Images showing snippets of the MTHFR and Methylation report from Xcode Life
Xcode’s MTHFR reports are easily readable, understandable, and implementable.
The core philosophy of Xcode reports is to empower the user with actionable genetic information that they can use to enhance health and well-being.
The report not only includes a number of genetic variants in the MTHFR, MTRR, MTHFD, and other genes but also detailed and practical recommendations on compensating for MTHFR deficiency.
| Xcode Life | Genetic Genie | |
| No. of variants analyzed | 64 | 21 |
| No. of genes analyzed | 15 | 9 |
| Results interpretation | Provided | Not provided |
| Bar graph result representation | Present | Not present |
| Recommendations | Included | Not included |
| Post-test one-on-one chat assistance | Available on request | Not available |
| Price | $30 | Free |
Do you struggle to stick to your diet plan because you always feel hungry and unsatisfied? This is one of the most common weight loss challenges. Cutting down on calories can make you feel hungry and increase cravings, thus doing more harm than good. But what if you could reduce your calorie intake while eating all you want? This is what volume eating is all about. Read on to find out the correct way to do volume eating and the top 12 low-calorie, high-volume foods that can satiate your hunger.
Volume eating is a diet where you eat large portions of nutritious foods like fruits, non-starchy vegetables, whole grains, and lean proteins.
It is based on the Volumetrics diet created in 2000 by nutrition scientist Barbara Rolls.
One common struggle for most people trying to follow a diet plan is battling hunger.
Volume eating keeps you satiated and feeling full longer, thus preventing cravings and helping you stick to your weight loss plan.
Since volume eating promotes a nutrient-rich diet, it can also help keep you in shape.
If you are trying to lose weight, volume eating can help you manage calories without counting them.
Volume eating lets you eat a satisfying amount of food without consuming excess calories.
It also helps you obtain all the required nutrients from your diet, such as fiber, protein, vitamins, and minerals.
When you feel full for longer and have a nutritious diet, you are less likely to give in to cravings and reach for junk food.
Thus, volume eating aids in weight loss by:
The key here is to include a variety of foods, not just those that are low in calories.
Oats can be a great addition to your daily diet. They are low in calories and high in fiber and protein and keep you feeling full for longer. Old-fashioned rolled oats showed better appetite control over four hours than ready-to-eat breakfast cereals.
Being high in protein, greek yogurt makes for a great addition to your diet. One cup of non-fat Greek yogurt provides 150 calories and 25 grams of protein. One study showed that women who snacked on Greek yogurt experienced much less hunger and felt satiated longer than those who snacked on crackers and chocolate.
Strawberries, blueberries, and raspberries are high in vitamins, minerals, and antioxidants. Berries also contain a dietary fiber called pectin, which slows stomach emptying and promotes feelings of fullness.
Eggs are rich in vital nutrients and low in calories. A large egg can provide 6 grams of protein, vitamins and minerals, and 72 calories. Consuming eggs can reduce the levels of ghrelin, the hormone responsible for hunger, in the body. Eating eggs for breakfast can help you feel full for longer.
Popcorn is a fiber-rich food that can stabilize blood sugar. It keeps you feeling full longer and is an excellent alternative to potato chips. Air-popped popcorn is the healthiest variant since other varieties might have added fat and sugar.
A 1-ounce serving of chia seeds has 4.7 grams of protein, 9.8 grams of fiber, and 138 calories. They have a unique soluble fiber that swells in your stomach and keeps you satiated longer. Incorporating them into your diet can help curb appetite.
Cottage cheese is rich in protein and can be incorporated into various meals. One cup of cottage cheese has 163 calories and 28 grams of protein.
With a reputation for being unhealthy and causing a spike in blood sugar, potatoes have been kept out of meals for a long time. But the reality is that they are rich in fiber and can keep you full for longer. One medium-sized potato contains 4 grams of protein and fiber and 161 calories.
Lean meats like chicken, turkey, and low-fat cuts of red meat are high in protein and low in calories.
Fish is rich in omega-3 fatty acids, which keep your heart healthy. They are also rich in protein, low in calories, and reduce the body's ghrelin levels. A study showed that fish protein keeps you feeling full longer when compared to beef and chicken.
With 92% water content, watermelons are a great low-calorie food choice. They are also rich in fiber, promoting fullness. Additionally, watermelons are a great source of antioxidants and vitamin C.
Soup can be incredibly filling, depending on the brand or type of soup you are cooking. Opt for broth-based soups instead of creamy soups to cut down on calories and maximize fullness.
Here are some more high-volume foods that are low in calories and are best for weight loss:
Volume eating, when done incorrectly, can end up harming your body.
It is best to consult a nutritionist or doctor before starting any diet.
Here are some low-calorie, high-volume meal ideas:
A 500-calorie diet is an extreme form of a very low-calorie diet (VLCD).
It is meant for people who are suffering from extreme cases of obesity and have been unable to lose weight despite trying other diet plans.
A 500-calorie diet requires drastically reducing your calorie intake, which can be dangerous without supervision.
While it is best to try under medical supervision, here is a list of foods you can have to feel full even after eating just 500 calories every day:
Here are some snack ideas that are l low in calories and will help in weight loss:
Foods that are sources of protein and fiber fill you up without weight gain.
Whole grain rice and bread, fruits, vegetables, and lean meat are low in calories and keep you feeling full for longer.
Low-calorie, high-volume foods keep you feeling full for longer without increasing calorie intake.
Over time, eating a high-volume diet can help you lose weight without eating less.
Some high-volume foods include fruits, vegetables, legumes, wholegrain bread and rice, eggs, and lean meat.
When done with a focus on balanced nutrition, volume eating can reduce cravings and aid in weight loss.
However, when you include or exclude foods from your diet simply based on calories, it could lead to a deficicny of essential fats in the body.
An excess of fiber, typical for most foods that keep you full longer, can lead to digestive problems.
If you want to try volume eating, consult a nutritionist or your healthcare provider for optimum results.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054218
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00063-4/fulltext
https://pubmed.ncbi.nlm.nih.gov/25266206
Have you ever noticed severe tooth pain and wear despite an excellent oral hygiene routine? Ten percent of adults experience bruxism, involuntary teeth grinding in their sleep. It can happen due to sleep disorders or excessive snoring. Over time, it can damage your teeth and jaws. Your genes can put you at a higher or lower risk of developing bruxism. That’s why it’s vital to understand bruxism and your possible genetic risk for it.
Bruxism can happen due to:
Some common symptoms of bruxism are:
Research has shown that teeth grinding can be genetic and run in families.
If your close relatives have bruxism, you are at risk of developing this disease.
21-50% of people with a close family member with bruxism will develop this condition.
NTRK2 and BDNF genes have a link to your risk for bruxism.
These two genes are involved in stress regulation pathways.
People with altered serotonin receptors are at an increased risk of developing bruxism.
Serotonin is a neurotransmitter that influences mood and memory.
Changes in the serotonin receptors, such as HTR2A, can decrease serotonin levels in the body.
It might result in anxiety, which is the leading cause of teeth grinding.
Common antidepressants like SSRIs can put you at risk of developing bruxism.
Stress and anxiety are the leading cause of teeth grinding.
Clenching your teeth when you are stressed or anxious is typical behavior.
It continues in your sleep as sleep bruxism.
You can also develop this condition due to genetics.
Bruxism can run in families and increase the risk of developing this condition.
Sleep disorders such as apnea can also cause teeth grinding.
Studies have shown that nearly 50% of children experience teeth grinding at night.
Teeth grinding can start as soon as teeth come in, so even toddlers and infants can suffer from bruxism.
It can occur due to:
Bruxism is both a neuromuscular and a dental disorder.
Physicians do not usually treat this disorder.
Dental surgeons and TMD specialists are better equipped to treat this condition.
Teeth grinding is often a problem in children with autism.
In addition, they often cannot communicate clearly with their caregivers.
Thus, it becomes difficult to treat them, and their oral health gets compromised.
They might also have eating and sleep disorders, aggravating the problem.
There can be several consequences if teeth grinding goes untreated:
Teeth grinding cannot be cured entirely.
Several preventive measures can relieve symptoms and decrease teeth and jaw damage.
While some people might not need help at all, here’s what you can do if your bruxism turns serious:
Chronic bruxism can compromise your oral health.
If left untreated, you might develop tooth pain and problems.
Your enamel will erode, exposing the underlying dentin.
An exposed dentin could make your teeth painfully sensitive to cold or hot foods.
Bruxism can also cause chronic jaw pain, which can become more severe over time.
Are Cavities Genetic? The Root Cause
Bad Teeth Genes: Can Dental Issues Run In Families?
Are UTIs Genetic?
With the rise in genetic testing, the MTHFR gene has become a hot topic of conversation. Many are eager to understand how these mutations might influence their health, leading to a surge in MTHFR testing. But along with this growing interest, there's a wave of misinformation that can easily lead to confusion and unnecessary worry. Are MTHFR mutations something to be concerned about? Does it have significant health implications, or is it just another health trend? This article will delve into myths vs facts, providing you with a clear and accurate understanding of MTHFR mutations and their true impact on your health. Let's dive in.
The MTHFR gene produces an enzyme with the same name - MTHFR.
Methylene-tetra-hydro-folate-reductase acts on an inactive form of vitamin B9 (folate), converting it to a useful form for the body.
Active folate helps reduce the levels of a harmful molecule called homocysteine in our body, producing a beneficial molecule named methionine instead.
Methionine helps our body synthesize proteins and other vital compounds.
A mutation in the MTHFR gene means the MTHFR enzyme produced can’t do its job effectively.
There are two kinds of MTHFR variants: C677T and A1298C.
This means that the nucleotide C at position 677 on the gene was replaced by the nucleotide T.
Similarly, A at position 1298 may be replaced by C.
These mutations are fairly common among populations today.
An ineffective MTHFR enzyme cannot produce enough folate to regulate homocysteine levels in the body. This condition is known as homocystinuria.
Increased levels of homocysteine can lead to the following health conditions:
Knowing whether you carry the MTHFR mutation can help you stay prepared for your later years and know if you’re passing your risk to future generations.
The health risks associated with MTHFR mutations are present only if an individual has two copies of a mutated MTHFR gene.
This means that a child with an ineffective MTHFR enzyme will have inherited two copies of an MTHFR mutation, one from each parent.
The mutation will come into effect if the child carries:
MTHFR isn't the only gene associated with homocystinuria.
In fact, another gene called, CBS has a stronger association.
Only extreme situations lead to a full-blown mutation, and the detection of an MTHFR variant on a report isn’t necessarily a cause for concern.
While it’s true that a mutated MTHFR enzyme can’t act upon folates effectively, it’s also important to understand that your body has other ways of handling folates.
The folate level in your blood is more dependent on your folate intake than your MTHFR mutation.
Birthmarks like stork bites, sugar bugs, and sacral dimples could spook parents into worrying about the health of their infants.
However, they aren’t a cause for concern since they fade away as time passes.
Additionally, no studies have been published that show any correlation between these birthmarks and the adverse effects of the MTHFR mutation.
In most cases, no.
Even a double C677T mutation only lowers folic acid levels by 16%.
Folic acid levels also depend on various factors like diet and environmental exposure.
If the labs don’t indicate a severe deficiency, adding extra vitamin B9-rich foods to your diet should do the trick.
An MTHFR gene mutation test helps identify the aforementioned two common variants in this gene.
It is done with a saliva or blood sample.
Some direct-to-consumer genetic testing companies also allow you to upload your existing raw DNA ancestry test file to provide the MTHFR report.
The results will flag the variants, if present, and may also include recommendations for maintaining healthy MTHFR and folate levels.
It is important to discuss the results with your healthcare provider for further course of action.
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Learn your status for 14+ methylation genes, including MTHFR, MTR, MTRR, COMT, and AHCY.
Acetaminophen has been shown to have some side effects like asthma or pregnancy complications. Since MTHFR is part of a pathway that helps combat these side effects, it’s recommended to avoid acetaminophen if you have an MTHFR deficiency.
The MTHFR mutation is one of two genes whose mutations stand to trigger autoimmune diseases. It’s rare, but MTHFR can interfere with the immune system’s ability to detoxify your body effectively.
The C677T variant that leads to the MTHFR mutation has been linked to an increased risk of breast cancer in specific populations.
https://www.medicalnewstoday.com/articles/326181#linked-conditions
https://medlineplus.gov/genetics/gene/mthfr/#function
https://www.cdc.gov/folic-acid/data-research/mthfr/index.html
https://health.clevelandclinic.org/a-genetic-test-you-dont-need
Though most oral health conditions are preventable, 3.5 billion people worldwide suffer from cavities, gum diseases, and oral cancer. According to the Centre for Disease Control, 90% of adults 20 years and older have had at least one cavity in their permanent teeth during their lifetime. While some people have chronic and frequent dental cavity issues, other people avoid dental visits for years at a stretch! Could this mean dental cavities are genetic?
Dental cavities or regions of tooth decay are permanently damaged areas of tooth structure that result in cavitation(the formation of a hole) in the tooth’s structure.
Dental cavities occur due to:
Dental plaque is a thin, colorless, sticky film that covers the surfaces of teeth.
It harbors bacteria, food particles, and saliva when you eat.
If you don’t brush your teeth properly, plaque builds up and can harden.
Hardened plaque is called tartar; this layer is difficult to remove with simple brushing.
Dental plaque is an essential factor in the initiation of tooth decay.
Tooth cavities occur in five stages:
Bacteria in the plaque begin to produce acids.
These acids start demineralizing (dissolving) the enamel, the outer layer of your tooth.
As enamel begins to lose minerals, it forms a white spot on the teeth.
The white spot darkens to a brownish shade as the enamel breaks down further.
It eventually forms a cavity that a dentist can fill up and prevent from worsening.
You may not have any other signs or symptoms at this stage.
The decay progresses into the middle tooth layer, called the dentine.
Dentine is softer than enamel and tends to decay faster.
The dentine layer houses the tooth nerves.
That’s why your teeth suddenly become sensitive to hot or cold foods or drinks.
The decay reaches the innermost layer of the tooth, called the pulp.
The pulp contains nerves and blood vessels that nourish the tooth.
When tooth decay irritates the pulp, it starts to swell.
The pulp cannot swell freely since the tooth’s structure is firm.
It begins to apply pressure on the nerves and tissues below.
This pressure triggers the pain commonly associated with cavities.
An inflamed pulp causes an abscess (a pocket of pus) to form at the bottom of your tooth.
The infection could spread to nearby tissues if abscesses aren’t immediately addressed and drained.
The treatment for tooth cavities depends upon the stage at which you report to your dentist.
It can range from a simple filling to a tooth removal.
There is ample research to show that cavities are genetic.
Genes influence various factors that could increase your risk for cavities.
Amelogenesis is the process of the formation of the enamel.
This process determines the tooth’s size, shape, color, and likelihood of decay.
Genes could alter the proteins that are a part of this process.
This change, in turn, could affect the likelihood of cavity formation.
Streptococcus mutans is a bacterium present in a healthy oral cavity.
Your immune response influences the growth of this bacteria in the mouth.
Some gene changes result in weaker immune responses, which can lead to irregular growth of S.mutans.
This bacterial growth can increase your risk of cavities.
Some people have a genetic inclination to prefer sweet food more than others.
They seek out higher amounts of sweet foods.
Eating too many sweet foods can increase your risk of tooth cavities.
Saliva flow and consistency play a role in tooth decay and other oral diseases.
When saliva is thin and free-flowing, it can easily wash away bacteria from your teeth.
Thinner saliva reduces your risk of gum disease or other infections.
On the other hand, having less saliva increases the risk of tooth decay.
Studies have shown that women have less saliva than men, putting them at risk for tooth decay.
Saliva comprises various electrolytes, including sodium, potassium, calcium, magnesium, bicarbonate, and phosphates. They help inhibit caries formation and progression.
Specific gene changes result in inadequate electrolytes in saliva, increasing the risk for cavities.
The oral microbiome is the collection of microbes residing in your mouth.
It can lead to the development of numerous oral infectious diseases, including dental caries, periodontitis, and peri-implant disease.
Genetic factors can contribute to the imbalance in the gut microbiome, resulting in an increased risk for all these conditions.
An imbalanced gut microbiome increases your risk for all these conditions.
Besides the causes of tooth cavities mentioned above, other lesser-known factors include:
Tooth cavities are highly preventable, and here are a few practical tips for doing so, regardless of genetics:
Enamel damage can heal over time.
A cavity that has reached the dentine or pulp needs medical attention.
It isn’t always the case.
Certain foods can leave some stains on your teeth, discoloring them.
Mouthwash can significantly reduce the probability of getting a cavity.
However, an existing cavity from tooth decay needs medical attention.
Bad Teeth Genes: Can Dental Issues Run In Families?
Are UTIs Genetic?
How It Works: Are Freckles Genetic?
LifeDNA and 10X Health are two major players in the field of genetic testing. They both offer well-reputed tests to unlock insights into your DNA. Their reports provide valuable recommendations to help improve overall health and wellness. This article compares both companies based on report quality, pricing, user experience, user reviews, and privacy policies. LifeDNA or 10X Health? By the end of this article, you’ll be able to make the right call.
LifeDNA was founded in 2017 by Steve Markowitz.
It is headquartered in Hawaii and specializes in DNA-based health and wellness services.
LifeDNA offers three pricing plans for their genetic tests, ranging from $99 to $249.
10X Health is a company that provides personalized health solutions.
These include genetic tests, blood tests, multivitamin supplements, and more.
10X provides two kinds of genetic tests centered around health and nutrition.
They are priced at $599 and $1,299 respectively.
10X Health’s reports come with a 400-page guidebook that contains detailed information on each trait analyzed.
It also provides recommendations for nearly every facet of health and wellness.
LifeDNA provides shorter reports with clear trait outcomes and recommendations where applicable.
Both reports present their results lucidly.
Between the two companies, 10X Health has the more expensive reports.
They offer a genetic test for $599 and a precision genetic test for $1,299
Their Precision Genetic Test results include a 400-page guide to optimal nutrition and fitness.
The report prescribes personalized supplements to help manage health and weight, but you must purchase them separately.
On the other hand, LifeDNA offers better value for money.
They offer 3 products: a methylation test for $99, a wellness bundle for $199, and a wellness bundle with a DNA kit for $249.
Their plans contain reports on dozens of traits with actionable recommendations.
After receiving your DNA sample, LifeDNA can take up to 2 weeks to deliver their reports.
Since shipping a DNA kit can take time, LifeDNA allows you to upload raw DNA data from a few other genetic testing services.
10X Health takes 6 to 8 weeks to return genetic test results and doesn’t seem to accept DNA from raw data providers.
LifeDNA has a 4.0 score on Trustpilot.
Most users are satisfied with the presentation of their results and prompt customer service.
On the other hand, 10X Health has a score of 1.6.
Users aren’t happy with the generic nature of their reports and prescriptions.
While 10X Health has reached a wider audience, LifeDNA has better word of mouth online.
LifeDNA is transparent about user data security.
Each user’s data is encrypted safely, and the user has full control over it.
LifeDNA does not use or share genetic data for research or commercial purposes without the user’s consent.
Read LifeDNA’s privacy policy here.
10X’s privacy policy mentions 11 kinds of data they collect from their users.
They use this data to create a customer profile, which helps curate your experience on the site and the report’s content.
They may use this data for targeted advertising and commercial purposes.
Read 10X Health’s privacy policy here.
Some users aren’t satisfied with 10X’s methylation report.
10X Health only analyzes 5 genes for methylation.
In contrast, LifeDNA analyzes 12 genes at a fraction of the price.
Their methylation report also accepts raw DNA data from providers like 23andMe, AncestryDNA, MyHeritage, Living DNA, and FTDNA.
Thus, LifeDNA is the better choice for methylation genetic testing.
LifeDNA is a good pick for people who take a casual interest in genetic DNA testing.
Their reports are concise and delivered faster than 10X Health’s reports.
LifeDNA’s recommendations are contained within their reports, so it isn’t the right choice for people looking to overhaul their health and wellness lifestyle.
10X Health is the better option for people who want to make active changes in their lifestyle.
10X prescribes specific supplements to help with nutrition and fitness, which could improve your health in the long run.
Due to its pricing, 10X is not the right choice for people who want to understand their genetic makeup in a casual sense.
| Criterion | LifeDNA | 10X Health |
| Report Quality | Shorter, more concise | Longer, more detailed |
| Pricing | 3 reports: $99, $199, $249 | 2 reports: $599, $1,299 |
| User Experience | Reports delivered faster, better customer support | Reports delivered slower, poorer customer support |
| User Reviews | 4.0 stars on Trustpilot | 1.6 stars on Trustpilot |
| Methylation Genetic Testing | More genes analyzed | Less genes analyzed |
While 10X Health is a decent choice for genetic testing, LifeDNA is the better choice due to:
Understanding your body’s methylation processes with a genetic test is worth it.
It can help you address health risks to improve your overall well-being.
Xcode Life offers a comprehensive suite of reports at an affordable price.
Xcode delivers its reports within 24 hours and offers a free consultation on the results.
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