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Every menstrual cycle phase brings different physical and mental changes in females. GI issues, especially bloating, are common problems for millions. Bloating during ovulation occurs mid-menstrual cycle and can cause discomfort and a constant feeling of fullness. If you struggle with fluctuating weight and body shape, your menstrual cycle could be the culprit. Know more about why the ovulation phase causes bloating and the lifestyle changes to help combat this.

Did You Know? Your genes hold precious clues about nearly all aspects of your health and wellness. Harnessing this information can help you understand your genetic makeup and decide about your nutrition, fitness, and lifestyle choices. Learn more

What Is Bloating?

Bloating is a feeling of fullness or tightness in the abdomen area.

Bloating is a common problem in Americans, with 1 in 7 adults experiencing the symptoms weekly. 

According to research, females are more likely to experience bloating than males (19% vs. 10.5%).

Some of the common reasons for bloating are:

Menstrual cycles are a part of the reproductive system in those with a uterus and are a preparation of the body for a possible pregnancy.

Most females have a menstrual cycle of 24-38 days. 

The body goes through varied changes throughout the cycle, from day one of bleeding to the start of the next cycle.

There are different phases to the menstrual cycle; one such phase of interest is ovulation. 

The ovulation phase is the fertile window where the ovary releases the egg and can fall between day ten and day 17 of the menstrual cycle.

Bloating during ovulation is a common problem faced by millions globally.

What Changes Happen To The Body During Ovulation

The female reproductive hormones drive ovulation. 

Luteinizing hormone (LH) levels rise to help release the eggs from the ovaries and prepare them to travel toward the fallopian tube.

The follicle-stimulating hormone (FSH) and estrogen levels also increase during this phase.

Progesterone, another sex hormone, slowly increases levels from day one of ovulation to prepare the uterus for pregnancy. 

Some of the physical signs of ovulation are:

What Causes Bloating During Ovulation?

Hormonal fluctuations are the reasons for most physical and mental discomforts women face in their menstrual cycles.

During ovulation, sudden surges in the reproductive hormones could be causing fluid retention in the body.

Fluid retention adds to the signs of bloating during ovulation.

Ovulation Bloating And Weight Gain

Many women also see that they slightly gain weight during their mid-menstrual cycle. 

The weight gain could also be because of these hormonal surges.

Increased hormonal levels lead to fluid retention in the body.

Fluid retention worsens bloating signs and contributes to slight weight gain.

A 2011 study recorded self-reported fluid retention during different menstrual cycle phases in 62 healthy women.

This study reports that fluid retention in the body was highest on the first day of menstruation and started increasing during the ovulation phase.

So, it's normal to experience sudden weight gain and signs of bloating during the ovulation phase.

Is It Normal To Be Bloated During Ovulation?

Yes. It is normal to be bloated during ovulation.

For women with regular menstrual cycles, the bloating usually subsides 1-2 days after ovulation and may reappear during menstruation.

In women with conditions like polycystic ovary syndrome (PCOS) or endometriosis, bloating could be a constant discomfort throughout the menstrual cycle due to fluctuations in the sex hormones. 

Premenstrual Bloating vs. Ovulation Bloating

bloating during ovulation - Infographic explaining the associations of body temperature, hormone levels, and menstrual phase during the menstrual cycle.

Image source: https://en.wikipedia.org/wiki/Menstrual_cycle#/media/File:MenstrualCycle2_en.svg

Premenstrual syndrome (PMS) is a group of symptoms showing up between the ovulation and menstruation phases.

3 out of 4 women may experience PMS every month, and the symptoms can range from GI issues to mood swings, breast tenderness, headaches, and body pain. 

The PMS symptoms peak during the late-luteal phase, about a week before the onset of periods. 

In this phase, once the body realizes that there was no successful conception, the hormone levels start fluctuating again.

The levels of progesterone, FSH, and estrogen start dropping. 

This drop in hormones can cause fluid retention and bloating too. 

The differences between premenstrual bloating and ovulation bloating are explained below.

Premenstrual bloatingOvulation bloating
May occur 2-7 before the onset of bleeding.Occurs during the ovulation phase (10-17 days into the menstrual cycle).
Could be accompanied by cramps, mood swings, tender breasts, and food cravings.Could be accompanied by cervical mucus changes, libido changes, slight menstruation-like cramping, and breast tenderness.
Can last for 2-7 days or until the start of menstruation.Can last for 1-2 days.

How To Reduce Bloating During Ovulation?

Low FODMAP Diet

A low-FODMAP diet may help handle the signs of bloating during ovulation.

FODMAP stands for Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols.

These are short-chain carbohydrates found in high amounts in foods like the ones below.

These high FODMAP foods can trigger or worsen bloating. 

Instead, choose low-FODMAP foods like the following to help handle bloating.

Be Physically Active

Studies report that being physically active after a meal can help bring down the intensity of abdominal bloating. 

In a 2021 study, 94 participants were divided into two groups, and one group was asked to walk 10-15 minutes after every meal.

The intervention group’s signs of bloating and fullness were reduced after walking. 

Include Probiotic-rich Foods

Probiotics are good bacteria that are beneficial for gut health. 

Probiotic-rich foods can help reduce gas production, thereby improving bloating. 

Some natural sources of probiotics are yogurt, kefir, sauerkraut, and miso.

Increase Water Intake

There are different ways water can help bloating during ovulation.

Reduce Your Sodium Intake

An excess sodium in your diet can encourage water retention in the body. 

It is common to have junk food cravings and enjoy packets of crisps and other processed foods during ovulation.

However, this can be a major cause of bloating during ovulation.

Summary

  1. Ovulation is the process of releasing an egg from the ovaries between the 10th and 17th day of the menstrual cycle.
  2. Bloating during ovulation is a common sign in women, causing discomfort, weight gain, and a slightly fuller abdomen.
  3. Most reproductive hormones rise in levels during ovulation. The sudden hormonal spikes can cause bloating.
  4. Water retention during the pre-menstrual phase can lead to slight weight gain and bloating.
  5. Choosing a low FODMAP diet, staying physically active, improving water intake, and eating low-sodium and probiotic-rich foods can combat bloating during ovulation.

References

https://pubmed.ncbi.nlm.nih.gov/32809533/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154522/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27529/

https://www.sciencedaily.com/releases/2022/11/221123213555.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824367/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322543/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035544/

https://pubmed.ncbi.nlm.nih.gov/35143108/

https://www.health.harvard.edu/diseases-and-conditions/a-new-diet-to-manage-irritable-bowel-syndrome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122060/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322543/

Have you ever wondered why some people are more sensitive to stress while others handle it easily? The answer might lie in a gene called COMT. COMT, short for catechol-O-methyltransferase, is a gene that plays a crucial role in regulating stress response and dopamine levels in our brains. In this blog post, we'll explore what it means to have a slow COMT gene and discuss effective strategies to navigate its effects.


What does it mean to be a COMT Warrior or Worrier? Is a warrior better than a worrier in handling stress? All your questions about the COMT gene are answered in the video below.


What Is The COMT Gene?

Catechol-O-methyltransferase (COMT) is an enzyme that regulates the breakdown of catechols.

Catechols include dopamine, norepinephrine epinephrine, and estrogen metabolites. 

The COMT gene helps the body in making this enzyme. 

Functions

The COMT gene provides instructions for the functioning of the COMT enzyme.

The COMT enzyme breaks down brain chemicals called catecholamine neurotransmitters.

They include dopamine, norepinephrine, and epinephrine.

The slow variant of this gene has been associated with anxiety and mood disorders

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Check your COMT gene Warrior/Worrier status for free!

Types

The COMT gene produces two types of COMT enzymes.

  1. MB-COMT: The membrane-bound COMT enzyme (MB COMT) is produced by the brain's nerve cells. It is the more extended version of the COMT enzyme.
  2. S-COMT: The COMT gene has another shorter version of this enzyme, called soluble COMT. This enzyme is produced by kidney, liver, and blood cells. 

The COMT Genotypes: Warrior vs Worrier

There are three variants of the COMT gene.

GenotypeAmino acidEnzyme activityStress response and other effects
AA Met/MetLow: WorrierPoor; lower pain threshold, more efficient at processing information under most conditions
AGMet/ValIntermediateAverage; moderate pain threshold, moderate cognitive performance
GG Val/ValHigh: WarriorGood; higher pain threshold, modest reduction in executive cognition performance under most conditions

It is important to note that even though the AA variant of COMT is associated with poor stress response, it also provides an advantage in memory and attention tasks.

What Is The Slow COMT Gene?

The worrier variant or the COMT Met allele is also called the slow COMT gene since it results in the slow breakdown of dopamine and other catecholamines.

When you have this variant, your body has difficulty removing catechols from the system.

As a result, you are more sensitive to stress and more prone to anxiety. 

Who Has Slow COMT Gene?

About 20-30 % of Caucasians of European ancestry have the slow COMT gene.

It limits the body's ability to remove catechols.

It directly affects stress reactivity, health, and well-being of a person. 

Symptoms of Slow COMT Gene

No set of symptoms can conclusively tell that you have a slow COMT gene. Only genetic tests can reveal this information.

However, there are certain symptoms that are characteristic of a slow COMT gene. They include:

How To Deal With Slow COMT Gene?

COMT is a methylation gene

DNA methylation is a biochemical process required for normal development. Several B vitamins play an important role in DNA methylation.

How To Speed Up COMT?

A slow COMT gene may have difficulty removing them from the system as they trigger catechol release. 

An infographic describing 7 ways to speed up a slow COMT gene. The infographic contains both text and icons for illustrative purpose.

**Please consult a qualified specialist before making any significant changes to your diet. The content above is for informational purposes only and doesn’t substitute for medical advice.

COMT Gene Testing

If you have done an ancestry genetic test with companies like 23andMe, AncestryDNA, MyHeritage, etc., you can learn your COMT gene status in just 3 steps.

  1. Download your DNA raw data from your service provider
  2. Add the “Traits and Personality” report to your cart (or the Xcode Life Genome Pack for a 70% discount)
  3. Upload your raw data and receive your results within 24 hours.

In your report, look at the “Warrior Personality” and “Worrier Personality” sections in your report.

Summary

The COMT gene plays an essential role in our health and well-being. It regulates the COMT enzyme, which removes catechols from the body.

This gene can have 3 variants: a slow variant, an intermediate variant, and a fast variant.

Having the slow variant means that your body has a hard time removing catechols. It might make you more sensitive to stress and traumatic events and predisposed to depression. 

Cutting out certain protein-rich foods from your diet might help deal with a slow COMT gene.

Practicing stress reduction techniques helps deal with stress.


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References

https://medlineplus.gov/genetics/gene/comt/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345409/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759319/

https://www.snpedia.com/index.php/Rs4680

Do you wake up every morning feeling exhausted despite hours spent in bed? This isn't just a matter of inadequate sleep but could be a sign of a serious condition affecting health and quality of life. With a striking 40% of obese individuals experiencing significant sleep apnea and 70% of OSA patients being obese, the search for effective solutions becomes crucial. Could weight loss be the most powerful tool in tackling this widespread issue? Read further to see how making one significant lifestyle change might hold the secret to better sleep and improved health.

Understanding Sleep Apnea

Sleep apnea is characterized by repeated breathing stoppages during sleep. It causes sleep disruptions and increases the risk of long-term health issues.

The most common form, obstructive sleep apnea (OSA), arises when throat muscles relax and block the airway. 

This blockage causes pauses in breathing, resulting in low oxygen levels, which trigger the brain to wake the body just enough to restore normal breathing.

Although this response prevents suffocation, it interrupts the sleep cycle and stops the body from reaching the deep, restful sleep necessary for overall health.

If sleep apnea remains untreated, it can contribute to serious health risks, including heart disease, hypertension, and stroke.

Common treatments for OSA focus on keeping the airways open during sleep. These include:

These treatments aim to improve sleep quality and prevent the health risks associated with sleep apnea.

This relationship is complex and multifaceted, as each condition can exacerbate the other, worsening symptoms and overall health.

Obesity, characterized by excessive body fat, particularly around the neck and abdomen, can significantly increase the likelihood of developing OSA.

Conversely, OSA can lead to weight gain and make it more difficult for individuals to lose weight, creating a vicious cycle that is hard to break.

How Weight Gain Contributes To Sleep Apnea

Excess fat around the neck and upper body can put pressure on the airways and cause them to collapse during sleep, leading to breathing interruptions and apnea episodes.

Studies have shown that for every 1-point increase in body mass index (BMI), the risk of OSA increases by 14%.

Obesity or being overweight contributes to OSA in the following ways:

  1. Physical pressure on airways: The pressure on the upper airway during sleep can lead to airway obstruction, a hallmark of OSA.
  2. Inflammation: Obesity is associated with increased inflammation in the body, which can contribute to the narrowing of the airways. Fat tissue releases inflammatory substances that can further compromise respiratory function.
  3. Hormonal changes: Increased body fat can lead to hormonal changes that affect sleep patterns and respiratory control. For instance, higher levels of leptin, a hormone produced by fat cells, can disrupt the normal regulation of breathing during sleep.

How Sleep Apnea Contributes To Weight Gain

Sleep apnea can lead to weight gain through several mechanisms:

  1. Disrupted sleep patterns: OSA causes frequent awakenings throughout the night, leading to poor sleep quality. Lack of restorative sleep can disrupt hormones that regulate appetite, such as ghrelin and leptin, leading to increased hunger and cravings.
  2. Fatigue and reduced activity: People with OSA often experience daytime fatigue, which can result in decreased physical activity. This sedentary lifestyle can contribute to weight gain over time.
  3. Metabolic changes: OSA is linked to insulin resistance and metabolic syndrome, conditions that can make it more difficult to maintain a healthy weight. The stress of repeated apneas can also lead to increased cortisol levels, which is associated with weight gain, particularly in the abdominal area.

Weight Loss as a Treatment for Sleep Apnea

Weight loss is an effective strategy for managing obstructive sleep apnea (OSA), particularly for individuals who are overweight or obese. 

According to a mathematical model, for every 7-pound drop in weight, there is a corresponding 7% decrease in the apnea-hypopnea index (AHI), which measures the severity of sleep apnea.

Let us see how weight loss helps treat sleep apnea.

  1. Reduction in airway obstruction: Research indicates that losing just 5-10% of body weight can significantly improve sleep apnea symptoms. More specifically, a 2022 study involving 180 participants indicated that a 5% weight loss improved symptoms, while a 10% loss provided even greater benefits.
  2. Localized fat loss: Research has shown that weight loss can also reduce fat deposits in specific areas, such as the tongue, which can block the airway. A small study in 2019 found that participants who lost weight experienced a reduction in tongue fat, leading to improved apnea symptoms. This suggests that targeted weight loss can have a direct impact on airway function during sleep.
  3. Overall Health Benefits: Weight loss not only helps with sleep apnea but also improves overall health. It can reduce the risk of associated conditions such as high blood pressure, diabetes, and cardiovascular disease. A review in Obesity Reviews noted that weight loss of 10-15% can reduce the severity of OSA by up to 50% in moderately obese patients, leading to better sleep quality and daytime functioning.

It is important to note here that while weight loss significantly improves OSA, it may not fully resolve the condition for everyone.

Other treatments, such as CPAP therapy, may still be necessary.



Effective Weight Loss Strategies For Sleep Apnea

Combining dietary changes, increased physical activity, and behavioral therapy can significantly improve weight loss and sleep apnea symptoms. Here’s how:

Dietary Changes

A calorie-restricted, well-balanced diet is fundamental for weight loss, particularly for those managing sleep apnea.

Aiming for around 1,200–1,500 calories* per day for females and 1,500–1,800 calories* for males is recommended. This approach helps reduce excess body fat, which is often linked to the worsening of sleep apnea.

Increased Physical Activity

Physical activity is vital to both weight loss and improving the body's overall functioning.

Regular exercise burns calories and strengthens muscles that help maintain open airways during sleep.

Behavioral Therapy

Behavioral therapy can be instrumental in developing sustainable weight loss habits and overcoming mental or emotional barriers that may affect weight management.

Complementary Strategies Alongside Weight Loss

While weight loss is a critical intervention, there are additional lifestyle changes and therapeutic approaches that can amplify its effects.

Let’s take a closer look at these strategies:

However, CPAP therapy and other sleep apnea treatments may still be necessary in some cases, especially when OSA is moderate to severe.

Summary


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References

https://www.ahajournals.org/doi/full/10.1161/01.hyp.0000101686.98973.a3

https://my.clevelandclinic.org/health/diseases/8718-sleep-apnea

https://www.nhlbi.nih.gov/health/sleep-apnea/treatment

https://www.sleepfoundation.org/sleep-apnea/weight-loss-and-sleep-apnea

https://www.atsjournals.org/doi/10.1164/rccm.201903-0692OC

https://www.healthline.com/health/sleep-apnea/sleep-apnea-weight-loss

https://www.hopkinsmedicine.org/health/wellness-and-prevention/choosing-the-best-sleep-position

https://www.nature.com/articles/s41598-023-34956-5

https://www.sleepapnea.org/snoring/mouth-exercises-to-stop-snoring/

https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/relaxation-technique/art-20045368

What is common in up to 90% of those who are pregnant, 70% of adolescent females, and, surprisingly, 40% of males? Stretch marks! Also known as striae distensae, stretch marks are often a result of sudden weight gain, pregnancy, or growth spurts. Despite this high prevalence, how do some people manage to avoid stretch marks altogether? Is it due to a religious coconut oil sugar scrub routine, or are there some hidden genetic factors at play? This article delves into the hereditary nature of stretch marks and explores whether they could be genetic.

How Are Stretch Marks Formed?

Striae distensae or stretch marks are scars that develop in the skin when it expands or shrinks. This puts excess pressure on the collagen and elastin that support the skin, ultimately causing breakage in them. This leads to the appearance of scars.

While stretch marks are not medically serious, they can affect a person’s appearance. Females are at a higher risk of developing stretch marks than males.

Stretch marks commonly appear on the abdomen, breasts, shoulders, and thighs. In children experiencing growth spurts, you can also see stretch marks on the thighs and buttocks.

What Do Stretch Marks Look Like?

Stretch marks start out as thin pink or pale-colored lines on the skin. As they develop, lines perpendicular to the skin tension start developing.

These lines look slightly swollen and can turn pink or purple in color. Mature stretch marks are pale-white in color.

Are Stretch Marks Genetic?

Genetics is one of the most significant factors that contribute to stretch mark development. There's no one "stretch mark gene," but a group of genes that regulate skin elasticity, collagen, etc., together influence the risk of stretch marks.

According to a study, females with a family history of stretch marks were more likely to develop them during pregnancy, further supporting the role of genetic factors in the development of stretch marks.

Let's explore some genes known to be involved in stretch marks.

ELN Gene and Stretch Marks

The ELN gene helps produce a type of protein called tropoelastin.

Multiple copies of this protein join together to become elastin fibers. They provide stretch, recoil, and elasticity to the skin.

Certain changes in the ELN gene can interfere with the normal functioning of elastin protein, leaving the individual susceptible to stretch marks.

The T allele of the rs7787362 SNP (an SNP is a single-letter change) in the ELN gene is associated with an increased risk for stretch marks.

FN1 Gene and Stretch Marks

The FN1 gene produces two types of proteins - cellular fibronectin-1 and plasma fibronectin-1.

Plasma fibronectin-1 attaches itself to other proteins in the skin, including.

This helps strengthen the tissues and helps repair them, too.

Certain changes in this gene result in lower fibronectin levels, which may result in poor tissue repair, increasing the risk of stretch marks.

The A allele of the rs3910516 SNP in the FN1 gene is associated with an increased risk for stretch marks.


Did You Know?

Many aspects of our skin health, from the risk for adult acne and premature wrinkles to the ideal personalized skincare routine, are influenced by our genes. This information may just be the key to unlocking healthy skin for graceful aging. You can use your existing ancestry test DNA data to access these insights and much more!
Learn How.


Non-genetic Influences on Stretch Marks

Pregnancy

Pregnancy is the biggest non-genetic influence on stretch marks.

But the tendency to develop even pregnancy stretch marks can be genetic!

About 90% of women develop stretch marks during pregnancy and continue handling them for the rest of their lives.

Women with larger abdominal areas and more weight gain during the pregnancy period develop severe striae distensae.

Overweight and Obesity

Up to 43% of people who are overweight and obese develop striae distensae in their lifetimes.

The increase in weight puts more stress on the skin.

As a result, it stretches it beyond its usual capacity, leading to stretch marks.

Cushing Syndrome

Cushing syndrome is a result of excess cortisol hormone in the body.

Cortisol is an important hormone that reduces inflammation, regulates blood pressure, and helps the body handle stress.

Cortisol-based drugs are prescribed to handle inflammatory diseases and chronic pain. Sometimes, the body overproduces this hormone. This results in Cushing syndrome.

The main symptom of Cushing syndrome is the development of stretch marks (pink and purple lines) all over the breast, buttocks, abdomen, thighs, and shoulders.

Other Health Conditions

Some conditions like anorexia nervosa, Marfan syndrome, and chronic liver diseases can make an individual prone to developing stretch marks.

Corticosteroid Creams

Corticosteroid creams, lotions, and gels are prescribed to treat conditions like eczema, itching, dermatitis, and psoriasis.

Corticosteroids can decrease the skin’s ability to stretch and cause stretch marks.

Breast Enlargement Surgery

Those opting for breast enlargement surgeries are at higher risk for developing stretch marks.

Placing an implant under the breast skin causes it to stretch and cover the larger area.

This can lead to the development of striae distensae.


Download Your 23andMe Data For 1000+ Health And Wellness Insights


Recommendations To Prevent and Manage Stretch Marks

Avoid Rapid Weight Gain and Weight Loss

Losing and gaining weight gradually will give your skin time to adjust to the new changes and prevent the appearance of stretch marks.

Natural Remedies

Natural remedies work only in the initial stages of stretch marks and not on mature marks. While they may not be able to get rid of the marks completely, they may improve their appearance. Here are a few options you can try out.

Dermatological and Cosmeceutical Creams, Lotions, and Gels*

There are two ingredients in topical creams that seem to be effective.

They are available as over-the-counter medications. These are also only most effective when applied as soon as you spot signs of stretch marks. As the marks get more mature, treating them will be difficult.

Microdermabrasion*

Microdermabrasion is performed by an expert in a clinical setting.

This involves removing the top layers of the skin to help finer and better skin grow back.

Microdermabrasion can help bring down the intensity of striae distensae scars.

Chemical Peels*

Chemical peels are being used widely to bring down the prominence of stretch marks.

These peels remove the topmost or the subsequent layers of the skin and give a faded appearance to stretch marks.

They cannot completely remove the marks, though. Regular chemical peel treatments can harm the skin.

As of now, there is no recommended treatment or lifestyle change that can completely remove stretch marks or prevent them from appearing.

Maintaining a healthy weight, keeping the skin moisturized and hydrated, and treating the early signs of stretch marks help.


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Summary

  1. Stretch marks or Striae distensae are scars that develop in the skin when skin rapidly stretches or shrinks. Stretching and shrinking cause breakage in the collagen and elastin in the skin, leading to the appearance of scars.
  2. Fibronectin protein attaches to other proteins in the skin to maintain its rigidity. Changes in the FN1 gene (that produces fibronectin) can increase your risk for stretch marks.
  3. Pregnancy, excessive weight gain or weight loss in minimal time, and conditions like Cushing syndrome, Marfan syndrome, and anorexia nervosa all result in the appearance of stretch marks.
  4. The use of cortisol-based drugs and topical corticosteroid drugs also contributes to the risk of developing Striae distensae.
  5. Women who have had breast enlargement surgeries also tend to develop stretch marks on and around the breasts.
  6. Most natural remedies can prevent the maturing of stretch marks when caught early. Dermatological creams that contain hyaluronic acid and Tretinoin also work on only early marks.
  7. As of now, no treatment has been able to completely remove the signs of stretch marks in the skin.

References

https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181654/
https://www.aad.org/public/cosmetic/scars-stretch-marks/stretch-marks-why-appear
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615396/
https://www.mayoclinic.org/diseases-conditions/stretch-marks/diagnosis-treatment/drc-20351144
https://emedicine.medscape.com/article/1074868-treatment#d9
https://www.ncbi.nlm.nih.gov/books/NBK436005/
https://pubmed.ncbi.nlm.nih.gov/23579949/

Gout is often thought to be the "disease of kings" due to its association with gluttony and alcohol consumption. This stigma has prevented us from exploring its root cause for many years. Research in the last decade suggests the cause of gout is a lot more genetics than just diet. Gout can affect anyone, but if you have an affected first-degree family member, your risk increases by 2.5x! This begs the answer to the question, "Is gout hereditary?" While we attempt to discuss this, we'll also touch upon how to learn your risk for gout via a genetic test.

Understanding Gout

Gout is one type of arthritis that results in inflammation, tenderness, and redness of one or more joints (ankles, wrists, fingers, and knees), most frequently the big toe joint. 

People with gout have high levels of a chemical compound called urate or uric acid in their blood (hyperuricemia). 

Generally, uric acid dissolves in the blood and is excreted by the kidneys through the urine. 

But sometimes, the body produces excess uric acid, or the kidneys excrete too little uric acid. 

During this stage, uric acid builds up, and forms sharp, needle-like structures called urate crystals that accumulate in joints, and the immune system reacts by causing inflammation. 

Types of gout:

Is Gout Hereditary?

With a strong genetic influence, gout is a condition that can be inherited. The heritability of gout is 65%!

Although there's no clear inheritance pattern, studies suggest that having a close affected family member can increase your risk significantly.

An estimated 20% of gout sufferers have a relative with the condition

To explore the heritability of gout, a group of researchers analyzed 4.2 million families. 

Study Observations

What Genes Cause Gout?

A meta-analysis published in 2018 suggests that the impact of genes on gout was much more significant than that of diet.

The study was done on 16,760 individuals with European ancestry.

They were exposed to several food items, some of which increased serum urate levels and others that it.

The researchers observed that diet only contributed to ≤0.3% of the variance in urate levels; by contrast, genetics contributed to a whopping 23.9% of the variance!

Genes that produce proteins that are responsible for urate transport play a prominent role in gout. 

Urate transporters mediate urate excretion.

A variation in one of these urate-related genes may cause gout. 

The genes that have so far been identified to have the strongest association with gout include

SLC2A9 Gene and Gout

The SLC2A9 gene produces a protein called GLUT-9, which is found in the kidneys. 

This protein regulates the reabsorption of urate from the urine back into the blood. 

It also assists in the removal of urate through urine. 

A mutation in the SLC2A9 gene may result in increased urate reabsorption or decreased urate excretion. 

This could lead to hyperuricemia and, eventually, gout.

ABCG2 Gene and Gout

The ABCG2 gene produces a multifunctional transporter protein called ABCG2, primarily in the stomach and liver. 

The protein regulates the excretion of urate via stools (or poop).

If the ABCG2 gene is altered, the protein won't be able to release urate into the intestines as it should. 

As a result, urate excretion may decrease, increasing serum urate levels and leading to gout.

Adapted From Gout Education Society

Symptoms Of Gout

Gout sufferers frequently experience sudden, excruciating pain attacks that start at night and last for up to 12 hours

This extreme discomfort, which usually begins at night, is a significant symptom of gout. 

Most people only have pain in one particular joint. Your big toe is commonly where it starts, although it can happen anywhere. 

Other gout symptoms include:


Did You Know?

Many chronic conditions like diabetes, hypertension, or gout are influenced by many gene changes. Each change adds to the risk of developing the condition. You can learn your risk for these conditions as well as recommendations to lower your risk using your existing ancestry test DNA data.
Learn How.


Who Is Prone To Gout? Risk Factors Explained

Now that we have seen that family history and genes play a vital role in gout risk let's explore some of the other factors that can contribute to the risk.

Can Genetic Testing Predict The Likelihood Of Developing Gout?

At present, no genetic test can confirm with 100% accuracy whether or not you'll get gout. But, it can really be helpful in understanding your risk for the condition.

These tests analyze commonly-associated genes with gout to identify the presence of genetic variants, if any.

If you possess a genetic variant, you may be at risk for gout.

You can then discuss the results with your doctor, who, after considering your medical, family, and personal history, can recommend steps to lower your risk and prevent gout.

Xcode Life's Gout DNA Report

Researchers have identified several genes associated with gout.

Xcode Life's Gene Health report, which analyzes your genetic risk for over 45+ health conditions, can help you understand your gout risk.

You can identify your genetic risk of gout by using your 23andMe (or any ancestry test) DNA data and placing an order for the Gene Health Report.

A Sample Gout DNA Report

Gout Genetic Test: A section of the xcode life's gene health report showing sample results for gout

Summary: Is Gout Hereditary?

  1. Gout is a prevalent and complicated form of arthritis that anyone can develop.
  2. A high level of uric acid in the blood (hyperuricemia) is the primary reason for gout.
  3. Extreme pain with redness, stiffness, and swelling in joints are the symptoms of gout.
  4. Studies have proven that gout runs in families and has a strong genetic association.
  5. Variations in the SLC2A9 and ABCG2 genes strongly influence the development of gout.
  6. Other risk factors include family history, gender, age, diet, medications, etc.

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References

Now called the "silent epidemic," vitamin D and vitamin B12 deficiencies can endanger the body in several ways. The ever-so-common constant bouts of tiredness, brain fog, bad mood, and body aches could all be explained by these deficiencies. But how are these two essential vitamins related? How can you increase your nutritional intake naturally? This article will help you understand vitamin D and B12 deficiencies, the signs to look out for, and easy ways to meet daily recommended doses of these vitamins.

Different nutrients have different roles in the body.

Nutritional deficiencies cause various physical and mental health issues in children and adults globally.

In some cases, one nutrient can affect the absorption or use of another, leading to a combination of health issues.

One such combination is vitamin D3 and B12 deficiencies. 

Importance Of Vitamin D and Vitamin B12

Vitamin D is a fat-soluble vitamin, also called the sunshine vitamin.

A majority of the vitamin is absorbed when UV rays from the sun come in contact with the skin. 

Vitamin D is available in certain foods and supplements in vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) forms.

Vitamin B12 is a water-soluble vitamin that is found in several kinds of foods and dietary supplements.

Importance Of Vitamin D

  1. It helps in calcium absorption and is essential for bone health.
  2. Reduces the risk of developing osteoporosis.
  3. Reduce inflammation in the body.
  4. Plays a role in healthy glucose metabolism.
  5. Helps in cellular growth.
  6. Supports the immune system by keeping immune T cells active.
Infographic of risk factors of vitamin D deficiency. 9 risk factors are depicted in the form of icons and text

Importance Of Vitamin B12

  1. It is required for the healthy development and functioning of the Central Nervous System (CNS).
  2. Helps in the healthy formation of Red Blood Cells (RBCs).
  3. It helps produce methionine, an essential amino acid that supports metabolism.
  4. It helps manage symptoms of depression and other mood disorders.
  5. It helps support brain health in fetuses.
  6. Helps in the production of hormones, including the thyroid.

Can Vitamin D and Vitamin B12 Deficiency Occur Together?

Yes; according to experts, low vitamin D levels may affect vitamin B12 absorption and lead to vitamin D and B12 deficiencies.

There are three ways vitamin D and B12 deficiencies can occur together. 

  1. An unhealthy diet and malnutrition may cause both vitamin D and vitamin B12 deficiencies together.
  2. Vitamin D deficiency may damage the stomach's mucosal (inner lining) layer. This may cause generic nutritional deficiencies, including vitamin B12 deficiency.
  3. Vitamin D deficiency may prevent the reabsorption of B12 and folate.

A 2022 study analyzed the relationship between vitamin D and vitamin B12 levels in children.

The study reported that children who are vitamin B12 deficient have a higher probability of also being vitamin D deficient.

What Is Wrong If Your Vitamin D-3 and Vitamin B-12 Are Low?

Low levels of Vitamin D3 and B12 can have significant impacts on your health.

Understanding the consequences of these deficiencies can help you take proactive steps to maintain your well-being.

  1. Genetic regulation and metabolism
    • These vitamins play a key role in regulating the functions of several genes.
    • Proper gene regulation affects hundreds of metabolic processes, ensuring your body operates smoothly.
  2. Bone health concerns
    • Brittle bones: Deficiencies can lead to bones becoming fragile and more prone to fractures.
    • Bone reabsorption and weakness: Lack of these vitamins may cause the body to break down bone tissue, weakening the skeletal structure.
    • Osteoporosis: Prolonged deficiencies significantly increase the risk of developing osteoporosis, a condition characterized by porous and fragile bones.
  3. Physical and mental symptoms
    • Fatigue: Persistent tiredness and lack of energy are common signs of low Vitamin D3 and B12.
    • Cognitive fog: Difficulty concentrating and mental clarity issues may arise.
    • Depression: Mood swings and feelings of depression can be linked to these deficiencies.
    • Body aches: Experiencing unexplained aches and pains throughout the body.
    • General malaise: A constant feeling of being unwell or sick without a clear reason.
  4. Pyrexia of Unknown Origin (PUO)
  5. Autoimmune Hypothyroidism

Signs of D3 and B12 Deficiencies

Here are some of the signs of D3 and B12 deficiencies.

*These signs could also be due to other reasons and health conditions. Please avoid self-diagnosing nutritional deficiencies and consult a doctor. 

How To Meet Vitamin D3 and B12 Requirements?

Meeting Vitamin D3 Requirements

Every cell in the body has vitamin D3 receptors on its surface.

The easiest way to meet daily vitamin D3 requirements would be to expose the hands, legs, face, and back to the sun for 5-30 minutes once a day, without sunscreen.

However, some people may have susceptible skin or have a higher risk of skin cancer due to sun exposure.

Such individuals can increase their vitamin D3 levels with food and supplements.

Recommended Dietary Allowance of Vitamin D

AgeMale (in mcg)Female (in mcg)
0-12 months1010
1-70 years1515
>70 years2020

Dietary sources of vitamin D

Meeting Vitamin B12 Requirements

Since the body does not make vitamin B12, you must depend on natural food sources and dietary supplements to get your daily recommended dose.

Recommended Dietary Allowance of Vitamin B12

AgeMale (in mcg)Female (in mcg)
0-6 months0.40.4
7-12 months0.50.5
1-3 years0.90.9
4-8 years1.21.2
9-13 years1.81.8
>14 years2.42.4

Dietary sources of vitamin B12

The bioavailability of vitamin B12 changes with the type of dietary source chosen. The bioavailability of supplements can be up to 50% higher than natural food sources.

Summary: Vitamin D and Vitamin B12 Deficiency Together

  1. Vitamin D and B12 are essential vitamins the body needs to perform everyday activities.
  2. Vitamin D deficiency may prevent the body from absorbing and reabsorbing B12, leading to vitamin B12 deficiency. 
  3. Individuals with vitamin D and B12 deficiencies may experience many signs in the body and brain.
  4. Some symptoms of vitamin D and B12 deficiencies are tiredness, fatigue, brain fog, memory loss, low energy levels, body aches, low immunity, and brittle bones.
  5. Individuals can receive their daily recommended doses of Vitamin D and B12 with sun exposure and the inclusion of dietary food and supplements rich in these nutrients.

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References

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