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Acid reflux can be quite painful, but it's bound to happen to many of us from time to time. The right diet is essential to soothe your digestive tract and prevent further flare-ups. We've prepared a 7-day acid reflux diet plan that can help ease the symptoms of this disease. Read on to learn what's right and what you should avoid if you're struggling with acute or chronic GERD.

What Is Acid Reflux Or GERD?

The American College of Gastroenterology defines GERD (gastroesophageal reflux disease) as a chronic condition where stomach acids flow back into the esophagus

Most people will experience occasional discomfort from stomach acid reflux.

However, if the symptoms occur at least twice a week and cause significant discomfort, a doctor can diagnose you with chronic GERD. 

Signs And Symptoms

The most common symptom of acid reflux is heartburn, a burning sensation in your chest. 

Other symptoms of acid reflux are:

If you experience several of these symptoms, particularly nausea and vomiting, you should contact your healthcare provider. 

Causes Of Acid Reflux

Though GERD has different triggers for different people, some common triggers of GERD include:

Foods To Eat With Acid Reflux/GERD

Here is a list of foods that don't trigger acid reflux:

What Food Immediately Gets Rid Of Acid Reflux?

No specific food can help you get rid of acid reflux symptoms immediately.

However, an over-the-counter antacid or baking soda mixed with water can help ease symptoms immediately. 

Is Peanut Butter Good For Acid Reflux?

Peanut butter is rich in healthy fats.

Sometimes, doctors recommend creamy peanut butter to soothe esophagitis (inflammation of the esophagus).

Esophagitis has links to acid reflux, meaning peanut butter might help with GERD.

Eating too much peanut butter at once could trigger or worsen acid reflux.

Until studies determine the right amount of peanut butter for GERD, follow your healthcare provider’s advice.

What Can I Drink To Neutralize Acid Reflux?

Here are some drinks that can neutralize acid reflux:

Do Probiotics Help With Acid Reflux?

Taking probiotics may help reduce symptoms of GERD by keeping harmful gut bacteria in check. 

Probiotics aid digestion and can speed up the treatment of certain intestinal infections.

However, the application of probiotics to GERD needs further research.

After consulting a doctor, you can give probiotic foods a try.

7-Day Acid Reflux Diet Plan

What Is The Best Meal For Acid Reflux?

The best meal for acid reflux includes low-fat, whole foods.

Consider including green vegetables, lean protein, and healthy foods.

Besides focusing on a balanced diet, here are a few more things to keep in mind when you have acid reflux:

Here’s a helpful 7-day acid reflux diet plan that could help manage GERD symptoms effectively.

BreakfastLunchDinner
MondayWhole grain bread, hard-boiled egg, and a pear.Whole grain roasted chicken tortilla and a salad.Brown rice, grilled salmon with asparagus.
TuesdayOatmeal in low-fat or plant-based milk, bananas.Brown rice, sauteed vegetables, and roasted chicken.Zucchini noodles and baked potatoes.
WednesdayScrambled egg white with whole grain bread, a melon. High fiber whole grain pasta, roasted chicken.Baked potatoes and papaya.
ThursdayOatmeal and bananas.Tuna salad and pita bread.Brown rice, roasted chicken, and carrot salad.
FridayLow-fat yogurt and berries.Whole tortilla with roasted turkey and broccoli.Whole wheat pasta with grilled shrimp.
SaturdayWhole grain bread and scrambled egg whites.Brown rice with grilled salmon.Grilled salmon with baked potatoes.
SundayOatmeal with bananas and apples.Tuna salad with pita bread.High-fiber pasta with roasted chicken.

Foods To Avoid With GERD

Here is a list of common GERD triggers to avoid if you currently have the disease:

FAQs About Acid Reflux

What To Make For Dinner With Acid Reflux?

If you suffer from acid reflux, consider consuming foods high in good fats and protein.

Here are a few dinner ideas if you have acid reflux:

What Soup Is Good For Acid Reflux?

The best soups for acid reflux are:

Avoid the following kinds of soups:

Having your soup too fast could also set off acid reflux.

What Fast Food Is Ok For Acid Reflux?

Eating out might seem daunting since it could trigger your GERD easily.

If you find yourself at a restaurant, here’s what to keep in mind:

Summary: 7-Day Acid Reflux Diet Plan


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References

https://pubmed.ncbi.nlm.nih.gov/30381627

https://www.niddk.nih.gov/health-information/digestive-diseases/acid-reflux-ger-gerd-adults/definition-facts

While most of us cannot even fully open our eyes without taking a sip of coffee first thing in the morning, a whole wave of online influencers have opposing views.

They recommend abstaining from coffee for 90-120 minutes after waking up to reap the full benefits of caffeine. 

They’re calling it the “game-changing” way of drinking coffee since it lets your body awaken more naturally and prevents the afternoon slump.

Is there a best time to have your morning coffee?
A tweet from Andrew D. Huberman discussing the effects of delayed caffeine intake each morning.
Source: https://www.instagram.com/hubermanlab/p/Cl2DawHv9Fk/

Coffee Wakes Us Up

The drowsy feeling that finally makes us want to put down our phones and pull up our blankets is all thanks to a hormone called adenosine.

It binds to certain receptors in the brain to induce sleep. Caffeine, structurally similar to adenosine, wards off sleep by binding to the same receptors, thereby blocking adenosine. 

Caffeine starts working as quickly as five minutes and typically hits its peak around 45 - 60 minutes after consumption, said Largemon-Roth, a New York-based registered dietitian nutritionist.

But not all of us respond the same way to caffeine.

What Is The Best Time For Morning Coffee? This is a graph that shows adenosine levels with caffeine exposure. When caffeine is consumed, plasma adenosine levels becomes higher since caffeine takes its spot and binds to the receptor. When caffeine is withdrawn, adenosine binds to the receptor, resulting in lower plamsa adenosine levels.

Caffeine Is Partial To Certain Genes

Approximately 95% of caffeine is metabolized by this one gene called CYP1A2 (pronounced sip-one-A-two).

CYP1A2 exists in many forms, each breaking down caffeine at different rates. 

If you have the “fast-metabolizing” form, then you eliminate caffeine quickly and will likely reach out for a second cup shortly after the first.

On the other hand, the “slow metabolizing” variant pushes out caffeine slowly.

Of course, body size, physical activity levels, smoking status, and certain medications, like oral contraceptives, also influence how caffeine is processed, added Mary Stewart, RD, a registered dietitian and the founder of Cultivate Nutrition in Dallas. 


Want to learn your caffeine metabolizer status?

Xcode Life's Genes And Caffeine Report uses your existing ancestry test raw DNA file to provide insights into how your body processes caffeine and associated health risks.

Rated 4.7/5 By Users Like You


Should You Delay Your Cuppa Joe? (The Best Time For Morning Coffee)

Cortisol, the major stress hormone in your body, is not just involved in fight-or-flight but also helps you be alert.

“You naturally release cortisol in the morning to help you become more alert and aware of your surroundings as you wake from your slumber,” DiMarino, a registered dietitian, explains.

Later in the day, when cortisol levels slowly start to decline, having your first cup of coffee can help avoid the energy crash, as explained by Emma Lowe, who shared their “delayed coffee” experience on MBG.

Even after you wake up, adenosine molecules still remain bound to their receptors for a while. So, with less competition for caffeine, the rationale is that it might not give you the energy boost you need.

When people consume caffeine immediately after waking, they often experience a significant energy dip in the early afternoon, known as the "afternoon crash." This crash occurs because the effects of the morning caffeine start to wear off, revealing the accumulated adenosine, says Andrew Huberman, a prominent American neuroscientist and podcaster.

Despite the claims and buzz, there’s little evidence to prove caffeine’s disruptive effects on the “natural waking up process.”

A 2019 study that examined the effects of caffeine on sleep-wake regulation reported that “Neither the time course of melatonin nor cortisol was significantly affected by caffeine or withdrawal.”

Why Delayed Coffee May Not Be For Everyone

According to the CDC, 1 in 3 adults do not get enough sleep

Considering caffeine’s proven effect on mental alertness and physical performance, it can really help you spring up to alertness first thing in the morning.

Let’s also not forget that for many, coffee isn’t just about the morning kick - its ability to trigger bowel movement has become a dependency.

As Huberman describes, if you work out first thing in the morning, having a cup of coffee right after you wake up can give you the energy boost for working out.

The Timing Of Your Last Cup Matters More

While caffeine’s wakefulness effect is a boon in the daytime, consuming it later in the day can interfere with sleep, leading to restless nights and groggy mornings, which is far from enjoyable.

So, it is important to time your last cup of coffee for the day.

While 6-8 hours before bedtime is the recommended time, slow metabolizers of caffeine may need to give it a good 10-12 hour-gap.

For most, cutting off coffee consumption by 12 PM - 2 PM can help prevent caffeine-induced sleep disturbances. 

The Bottom Line: What's The Best Time For Morning Coffee?

There isn’t a universal “best” time to have your morning coffee. Some people may find waiting 90–120 minutes after waking helps sustain energy levels into the afternoon. Others need that caffeine boost immediately to function—especially if they are not getting good nights' sleep, working night shifts, juggling a newborn’s schedule, or training for an early workout. Genetics, lifestyle, and individual tolerance play a significant role in how caffeine affects you. Regardless of when you take that first sip, be mindful of your last cup; cutting off caffeine 6–8 hours (or longer, for slow metabolizers) before bedtime can help ensure a good night’s sleep. Ultimately, the “right” timing is about balancing personal preference, daily demands, and healthy sleep practices.


Increasing awareness and wearable technology have expanded the potential of wellness journeys. However, achieving true well-being seems increasingly difficult. Across the world, the statistics tell the same story. One in four Americans struggles with depression, one in five is truly happy, and the rest are stuck in emotional limbo—neither happy nor depressed. Learning about the 12 dimensions of wellness and how to achieve them can transform every facet of your life, paving the way for true happiness and contentment.

Wellness In The Modern Age

Wellness in the modern age is an evolving concept shaped by technological advances, increased attention to mental health, and a deeper understanding of overall well-being.

Today, wellness extends beyond physical health to emotional, mental, and social aspects.

People now seek balance through mindfulness, meditation, and stress management, easily accessible through apps and online resources.

Diet and fitness routines have become more personalized, with technology providing insights into individual needs through wearables and health-tracking devices.

At the same time, there's a growing awareness of the importance of sleep, nutrition, and emotional connections contributing to a balanced lifestyle.

With the high productivity demands of modern routines, setting boundaries, nurturing supportive connections, and prioritizing self-care are more crucial than ever.

These trends suggest a more personalized, accessible, and sustainable approach to wellness, which would meet diverse needs and promote better living in today’s world.

The 12 Dimensions Of Wellness

In the 1970s, Dr. John Travis introduced the 12 dimensions of wellness, inspired by Dr. Halbert Dunn's ideas on wellness.

He opened the first wellness center in California and created The Wellness Inventory (1975) and The Wellness Workbook (1977).

These dimensions focus on different areas of life, helping individuals balance physical, emotional, mental, and spiritual well-being.

Below is an exploration of each dimension and its significance:

Self-responsibility & Love

This dimension shows the importance of self-care and self-compassion.

Prioritizing personal needs, developing a positive self-image, and reducing negative self-talk are vital steps toward achieving a balanced and fulfilling life.

Recognizing personal needs and addressing them enhances motivation and overall wellness.

Breathing

Breathing is fundamental for energy production and relaxation.

Mindful and intentional breathing practices can help reduce stress, calm emotions, and improve focus.

Becoming more aware of breathing patterns helps individuals stay present and focused.

Sensing

Our senses—sight, touch, smell, hearing, and taste—shape how we experience the world. However, modern lifestyles can dull these senses.

However, mindful engagement with everyday activities, such as eating or walking, can restore sensory awareness and improve decision-making, relationships, and overall presence.

Eating

Nutrition fuels the body and mind. A fresh, whole, plant-based diet supports physical and mental health.

Practicing mindful eating enhances digestion, reduces overeating, and increases appreciation for the food we consume, making it a key part of self-care.

This image highlights 4 of the 12 dimensions of wellness- Self-responsibility, breathing, sensing, and eating.

Moving

Movement is a natural expression of energy vital for physical and emotional well-being.

Engaging in fun physical activities and making them part of daily life helps avoid an inactive lifestyle, increase energy, and improve overall happiness.

Feeling

Emotions are essential to the human experience. Developing emotional intelligence involves recognizing and managing personal emotions while understanding others' feelings.

This ability enhances relationships and equips individuals to handle challenging emotions like anger or anxiety effectively.

Thinking

Thought patterns significantly impact overall wellness. Mindful thinking promotes positive choices and reduces the impact of negative or unwanted thoughts.

Understanding the brain's adaptability helps individuals reframe their thinking for personal growth and mental clarity.

Playing & Working

Balancing work with fun and creative play boosts energy and well-being. Play helps spark creativity and excitement, making it an essential addition to organized work.

Achieving this balance is vital for leading a happy and fulfilling life.

This image highlights 4 of the 12 dimensions of wellness- moving, feeling, thinking, and playing/working.

Communicating

Effective communication connects our inner thoughts with the outside world.

Improving listening skills and overcoming communication barriers strengthens relationships.

Positive self-talk is also key in supporting emotional and mental well-being.

Intimacy

Intimacy includes romantic relationships and deep connections with friends and family.

Trust and open communication are fundamental for building meaningful relationships.

Nurturing various forms of intimacy boosts personal and emotional well-being.

Finding Meaning

The search for meaning is at the core of human existence.

Reflecting on fundamental questions about identity and purpose provides clarity and strengthens our daily experiences.

When actions align with core values, individuals can lead more purposeful and satisfying lives.

Transcending

This dimension reflects spiritual growth and the ability to go beyond limitations.

It includes moments of deep immersion, connecting with something more significant, and nurturing balance across all dimensions.

Transcendence leads to peak performance and a stronger sense of being fully alive.

This image highlights 4 of the 12 dimensions of wellness- communicating, intimacy, finding meaning, and transcending

Genetic Wellness: The 13th Dimension?

Genetic wellness is a personalized approach to health that uses your unique genetic information to improve well-being.

Analyzing your DNA through genetic testing provides insights into how your body processes nutrients (nutrigenomics) and reacts to exercise (fitness genomics).

It also reveals your tendencies for traits like sleep patterns and stress response.

These tests can identify genetic risks for specific health conditions, allowing for early and proactive management.

Instead of general health advice, genetic wellness offers personalized recommendations for diet, exercise, and lifestyle based on your genetic profile.

These personalized insights help you make informed decisions to lower disease risks and refine your lifestyle for better health.

It’s important to note that genetic wellness testing focuses on identifying tendencies, not diagnosing conditions, and lifestyle decisions still significantly impact overall health.

FAQs About Wellness

What Does ASAM Stand For?

The American Society of Addiction Medicine (ASAM) was founded in 1954 and represents over 7,500 professionals specializing in addiction treatment.

ASAM focuses on improving addiction care, educating healthcare providers and the public, supporting research, and promoting the role of physicians in treating addiction.

What Are The ASAM Dimensions?

The ASAM dimensions provide a stepwise framework for biologically, socially, and psychologically assessing and treating individuals with addiction or substance use disorders.

The ASAM framework incorporates biological, psychological, and social factors into evaluations to create personalized treatment plans and improve recovery outcomes.

How Do You Maintain Work-Life Balance?

Achieving a work-life balance requires thoughtful strategy and planning. Here are some tips to get you started:

Balancing work and life is a constant effort that will require regular self-reflection and adjustment.

Summary: 12 Dimensions Of Wellness


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References

https://www.betterhealth.vic.gov.au/health/healthyliving/wellbeing

https://globalwellnessinstitute.org/what-is-wellness/history-of-wellness/

https://wvumedicine.org/wellness/programs/simple-steps-to-whole-person-wellbeing/

https://www.asam.org

https://www.healthdirect.gov.au/work-life-balance

We all know caffeine can give us the energy boost we need to power through our day, but could it also influence our hormones unexpectedly? Specifically, does caffeine impact testosterone levels, the hormone essential for muscle development, energy, and sexual well-being? The truth is that the relationship between caffeine and testosterone is more complex than you might think. While some studies suggest it could provide a slight boost, others indicate it might lower testosterone levels. This evidence-based review analyzes how caffeine affects testosterone, fertility, and erectile function, offering expert insights into its health and performance outcomes.

Effect Of Caffeine On Fertility

Caffeine has been studied for its impact on fertility, with mixed results across both male and female fertility studies.

Male Fertility

In males, studies have shown that caffeine from coffee, tea, or cocoa drinks does not significantly affect semen quality, including sperm count or concentration.

Meanwhile, caffeine from cola and soft drinks has been linked to lower semen volume and concentration.

Caffeine consumption was also associated with sperm DNA damage, including aneuploidy and DNA breaks, which may negatively impact male fertility.

Additionally, male coffee intake was associated with extended time to conception for couples.

Female Fertility

For females, higher caffeine intake, particularly between 300 mg and 600 mg daily, has been associated with an increased risk of miscarriage.

The risk rises by 37% at 300 mg and 132% at 600 mg daily.

However, no clear association was found between caffeine consumption and natural fertility or fertility treatment outcomes, such as clinical pregnancy or live birth rates.

Does Caffeine Affect Testosterone Levels?

The effect of caffeine on testosterone levels is complex and influenced by factors like dosage, duration of consumption, and individual differences.

Studies On Caffeine And Testosterone Levels

NHANES Study: The Effect Of Caffeine On Testosterone In Males

Using data from 372 adult males in the 2013–2014 NHANES survey, the study investigated how caffeine affects testosterone levels in males.

It found that higher caffeine intake was linked to lower testosterone levels.

Some caffeine byproducts, such as 5-methyluric acid, were particularly associated with lower testosterone.

On the other hand, 7-methylxanthine seemed to raise testosterone levels.

These results indicate that caffeine could lower testosterone, but more research is needed to clarify the mechanisms behind this effect.

Graphical representation of how caffeine dosage affects testosterone levels as observed in a clinical trial

Caffeine And Exercise: Effects On Testosterone And Cortisol In Athletes

This study examined how caffeine affects testosterone and cortisol levels in professional athletes during exercise.

Rugby players took different amounts of caffeine (from 0 to 800 mg) before working out.

The results showed that caffeine caused a small increase in testosterone during exercise. At the highest dose (800 mg), testosterone went up by 21%.

However, this was also linked to a significant rise in cortisol, a stress hormone, which can work against the benefits of increased testosterone.

Higher cortisol levels lead to a reduced testosterone-to-cortisol ratio, which may limit the effectiveness of caffeine in boosting testosterone.

While caffeine can help with performance, the cortisol spike might limit these benefits.

Effects Of Caffeinated And Decaffeinated On Sex Hormones: A Controlled Trial

This 8-week randomized controlled trial examined how caffeinated and decaffeinated coffee affects hormones in healthy adults.

After the 8 weeks, no significant changes were found in any of the results, including testosterone levels, from coffee consumption. However, at the 4-week mark, there were some notable differences:

Summary: Effect Of Caffeine On Testosterone Results

  1. Caffeine does not significantly lower testosterone in healthy adult males.
  2. Some studies note a slight, temporary rise in testosterone following caffeine consumption, especially around exercise.
  3. Long-term or chronic coffee consumption has been associated with small (often negligible) differences in testosterone levels in observational studies.

Thus, further research is needed to clarify these associations and understand the underlying biological mechanisms.

What’s The Relationship Between Caffeine Withdrawal And Testosterone Levels?

Caffeine withdrawal's impact on testosterone levels is generally minimal and indirect.

Although some studies indicate that caffeine may temporarily boost testosterone, quitting coffee is unlikely to cause a significant decrease in levels.

The primary way withdrawal could affect testosterone is through increased stress, as the symptoms can raise cortisol levels.

Prolonged high cortisol can interfere with testosterone production, but this effect is usually temporary and fades as the body adapts to being caffeine-free.

Caffeine And Testosterone: Expert Take

Insights from healthcare professionals reveal how caffeine impacts testosterone levels.

Andrew Huberman, Ph.D. (neuroscientist and podcaster at Stanford)
"Caffeine can slightly raise SHBG, which may reduce free testosterone levels. However, the impact is minor and doesn't exceed the benefits of proper caffeine consumption, enhancing mental and physical performance."
Dr. Jolene Brighten, NMD (naturopath and women's hormone expert)
"While studies on men suggest caffeine may lower testosterone levels, the impact on women is less clear. Some studies show caffeine could reduce testosterone in women but increase it in men. Overall, the results are mixed, and whether caffeine lowers testosterone likely depends on the individual."
Dr. Sam Robbins (anti-aging and hormone specialist)
"Caffeine can trigger a rise in stress hormones like cortisol and adrenaline, which decreases testosterone and can result in a decrease in erections."

Does Caffeine Affect Other Hormones?

Caffeine's influence extends to several other hormones, including:

Optimizing Caffeine Intake For Better Health

Enjoying coffee doesn't have to come at the cost of your health—simple strategies can help you optimize its intake:

Note: These are general tips, and caffeine’s effects may vary from person to person. For any concerns, it’s advisable to consult a healthcare provider.

FAQs: Caffeine And Testosterone Levels

Does Caffeine Increase Testosterone?

Caffeine may have a minimal effect on testosterone levels. Some evidence suggests a slight increase during exercise, with a 21% rise at high doses.

However, other findings indicate that caffeine's byproducts could decrease testosterone.

The overall effect varies between individuals, and more research is needed to understand its precise influence on testosterone.

Does Quitting Coffee Lower Testosterone?

Quitting coffee is not likely to cause a significant decrease in testosterone levels.

The connection between caffeine and testosterone is complex, with studies like the NHANES study by Lopez et al. showing non-linear associations.

This means the effect of caffeine on testosterone can vary depending on factors like consumption levels and individual variations.

Does Caffeine Affect Erections?

Caffeine may enhance erectile function by improving blood flow to the penis.

Studies suggest that moderate coffee consumption—about 2 to 3 cups a day—can help males get and sustain an erection.

Drinking 85-170 milligrams of caffeine each day is linked to a 42% lower risk of erectile dysfunction (ED).

Males who consume 171-303 milligrams daily have a 39% lower chance of ED compared to those who don’t drink caffeine.

This positive effect could be due to caffeine’s ability to relax the arteries and smooth muscles in the penis, which boosts circulation.

Additionally, caffeine may increase testosterone levels, an essential factor since low testosterone is often linked to ED.

However, some recent studies have found no clear connection between caffeine and ED, indicating that the effects may vary from person to person.

What Hormones Does Caffeine Block?

Caffeine doesn't directly block hormones in the way a medication might. Instead, it interacts with your body in ways that can influence hormone levels.

Some hormones that caffeine can affect include:

What Lowers Testosterone The Most?

Several factors can significantly lower testosterone, including:

Summary

Caffeine’s impact on testosterone is complex, with studies showing mixed results.

Some evidence suggests it can temporarily boost testosterone during exercise, while other findings indicate caffeine’s byproducts may lower testosterone in males.

Caffeine can negatively affect male fertility by reducing sperm quality and DNA health. In females, high caffeine intake elevates the risk of miscarriage.

Moderate caffeine consumption may improve erectile function and lower the risk of ED. 

Caffeine withdrawal can cause temporary stress and elevated cortisol but doesn’t significantly lower testosterone.

The overall effects of caffeine on hormones vary based on individual factors, dosage, and lifestyle.


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References

https://pmc.ncbi.nlm.nih.gov/articles/PMC5482951

https://pmc.ncbi.nlm.nih.gov/articles/PMC5733907

https://pmc.ncbi.nlm.nih.gov/articles/PMC9112543

https://pubmed.ncbi.nlm.nih.gov/18458357

https://pmc.ncbi.nlm.nih.gov/articles/PMC3502342

https://pmc.ncbi.nlm.nih.gov/articles/PMC2257922

https://ai.hubermanlab.com/s/848d01de-6c88-11ef-a5a9-2b312bd75228

https://drbrighten.com/how-coffee-affects-your-health-and-hormones

https://www.betterhealth.vic.gov.au/health/healthyliving/caffeine

https://pmc.ncbi.nlm.nih.gov/articles/PMC6758129

https://www.nih.gov/news-events/news-releases/nih-study-shows-caffeine-consumption-linked-estrogen-changes

https://pmc.ncbi.nlm.nih.gov/articles/PMC6298130

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123547

https://jhpn.biomedcentral.com/articles/10.1186/s41043-024-00645-w

https://www.acs.org/education/chemmatters/past-issues/archive-2013-2014/caffeine.html

https://www.webmd.com/diabetes/diabetes-and-caffeine

https://pubmed.ncbi.nlm.nih.gov/14592218

https://www.healthline.com/health/testosterone-killing-foods

The study of genetics and epigenetics helps us understand the complex factors influencing an organism’s health and development. Genetic studies focus on inherited traits, while epigenetics looks at how lifestyle, diet, and stress affect gene expression without altering the DNA sequence. This distinction highlights the dynamic relationship between nature (genetics) and nurture (environment), emphasizing that both play crucial roles in shaping health outcomes. One gene of interest in this context is MTHFR (methylenetetrahydrofolate reductase). It’s a gene involved in the methylation process, a key aspect of epigenetics. Keep reading to explore how environmental and lifestyle factors affect gene function and contribute to changes in methylation.

Genetics vs. Epigenetics

Genetics refers to the study of genes and how they influence the traits and characteristics of an organism.

Genes are inherited from parents and provide the blueprint for various biological functions.

Unlike genetics, epigenetics focuses on gene activity changes without altering the DNA sequence.

Epigenetics shows that an organism's environment can influence gene expression, sometimes overriding genetic predispositions.

For example, studies have shown that even mice with genetic predispositions to certain diseases can have healthy offspring if raised in a good environment.

Is MTHFR Epigenetic?

MTHFR, or methylenetetrahydrofolate reductase, is a gene that plays a crucial role in processing folate (vitamin B9) and regulating homocysteine levels in the body. 

This gene can be influenced by epigenetic factors, which are changes that affect gene activity without altering the DNA sequence itself.

MTHFR Methylation

Methylation is a common epigenetic change that acts like a switch.

It turns a gene 'off' when its functioning is not required. 

MTHFR is a vital enzyme in the methylation cycle. It is responsible for converting folate into its active form, 5-MTHF.

This active folate helps convert homocysteine into methionine, a protein-building block.

In some cases, the MTHFR gene can become over-methylated due to mutations, reducing its expression and lowering enzyme activity. 

MTHFR Hypermethylation

MTHFR hypermethylation occurs when excess methyl groups attach to the MTHFR gene's promoter region, reducing its activity and the production of the MTHFR enzyme.

This reduction can disrupt essential processes and lead to several health issues, including:

  1. Diabetes: Studies found that individuals with diabetic retinopathy (eye damage from diabetes) had more frequent hypermethylation (excessive methylation) of the MTHFR gene. This hypermethylated profile was linked to higher levels of bad cholesterol (LDL). In people with diabetic nephropathy (kidney damage), hypermethylation was linked to elevated levels of specific proteins and antioxidants.
  2. Alzheimer's disease: Epigenetic changes in the MTHFR gene are also associated with Alzheimer's disease, especially in older adults. The MTHFR gene helps produce SAM, which is essential for DNA methylation. Changes in this process can contribute to disease.
  3. Cancer: Epigenetic changes, including methylation, are common in many types of cancer. For example, in IDH-mutant glioma (a type of brain cancer), alterations in DNA methylation can activate oncogenes like PDGFRA, contributing to its development.

Xcode Life Methylation Genetic Test – What Is It?

The Xcode Life Methylation Genetic Test utilizes raw data obtained from popular ancestry genetic testing service providers like ​23andMe, ​Ancestry DNA, Family Tree DNA (FTDNA), Living DNA, and My Heritage to provide the MTHFR and Methylation report.

The test analyzes more than 15 genes associated with the methylation pathway, including MTHFR, MTRR, MTR, COMT, and AHCY.

For a sample MTHFR report/ preview of the report, click here.


What Is The Best Diet For MTHFR Epigenetics?

Maintaining proper MTHFR methylation and epigenetic balance starts with smart dietary and supplement decisions.

Explore the foods and supplements highlighted below to support these goals.

Is MTHFR epigenetic?
An infographic listing out foods that support MTHFR methylation

What Foods Increase MTHFR Methylation?

Dr. Josh Axe, a chiropractor and clinical nutritionist, states that certain lifestyle habits can help support normal MTHFR methylation, regardless of individual genetic factors.

These habits include consuming nutrient-rich foods such as folate, B vitamins, magnesium, and zinc.

Some of the best foods to support methylation include:

Supplements For Epigenetic Modifications

Specific supplements may help facilitate healthy epigenetic modifications like methylation. These supplements often contain:

Other compounds, such as curcumin (from turmeric), green tea extract, sulforaphane, and resveratrol, are also studied for their potential epigenetic effects.

Note: Always consult a healthcare provider first to ensure the chosen supplements are appropriate for your health.

FAQs About MTHFR And Epigenetics

Is Methylation A Form Of Epigenetics?

Yes, methylation is a form of epigenetics. It acts as a molecular switch, attaching a methyl group to DNA and thus regulating gene activity by turning genes on or off without changing the DNA sequence.

This control is essential to numerous biological functions, including disease development.

What Diseases Are Caused By Epigenetics?

Epigenetic changes can alter gene expression and contribute to the development of various diseases.

Some of the diseases influenced by epigenetic factors include:

Can Epigenetic Changes Be Reversed?

As demonstrated in a recent clinical trial, epigenetic changes are reversible.

The study involved 43 healthy adult males aged 50-72 participating in an 8-week treatment program.

This program included guidance on diet, sleep, exercise, relaxation, and the use of supplemental probiotics and phytonutrients. The control group did not receive any intervention.

The researchers measured epigenetic aging using a method called the Horvath DNAmAge clock.

The results showed that the treatment group had a 3.23-year decrease in epigenetic age compared to the control group.

Within the treatment group, their epigenetic age decreased by 1.96 years on average during the program.

Additionally, there were improvements in blood markers, such as a 15% increase in a nutrient called 5-methyltetrahydrofolate and a 25% decrease in triglycerides.

While this study suggests lifestyle changes may reverse epigenetic alterations, further research can confirm its claim.

Summary: Is MTHFR Epigenetic?


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References

https://pmc.ncbi.nlm.nih.gov/articles/PMC3193653

https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-017-0284-3

https://pmc.ncbi.nlm.nih.gov/articles/PMC6359124

https://www.cancer.gov/news-events/cancer-currents-blog/2019/gist-epigenetic-changes-oncogene-activation

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/methylenetetrahydrofolate-reductase

https://pmc.ncbi.nlm.nih.gov/articles/PMC5735284

https://pmc.ncbi.nlm.nih.gov/articles/PMC8339558

https://www.sciencedirect.com/science/article/abs/pii/S1751499110000417

https://www.mdpi.com/2072-6643/16/5/678

https://pmc.ncbi.nlm.nih.gov/articles/PMC7750768

https://pmc.ncbi.nlm.nih.gov/articles/PMC8327151

https://www.sciencedirect.com/science/article/pii/S0925443916303246

https://pmc.ncbi.nlm.nih.gov/articles/PMC8064200

We often hear stories about people who eat specific foods like nuts, seafood, etc., and develop a rash on their bodies or breathing difficulties. These instances occur because an individual eats a food they are allergic to. If there was a way to determine what foods you are allergic to, most people could avoid the foods that cause them allergies. The good news, however, is that there are tests that help identify foods that may trigger an allergic reaction. In this artilce, we will learn more about food sensitivity tests—their types, uses, and more.

Food Sensitivity, Intolerance, And Allergy: What's The Difference?

Before understanding more about food sensitivity tests, let’s get our terminologies right!

Food sensitivity, intolerance, and allergy are often used interchangeably.

However, these are not the same.

Food Intolerance

With food intolerances, the body lacks certain enzymes necessary to break down a particular food item. 

Food intolerance may cause stomach upset or other digestive problems.

They are not related to the immune system, nor are they typically life-threatening.

Food Sensitivity

This stems from an immune reaction and is driven by antibodies like immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA).

Symptoms of food sensitivity include digestive issues like gas, diarrhea, abdominal pain, joint pain, brain fog, and migraine.

These food sensitivity symptoms are subtle and usually do not occur immediately.

Food sensitivities are mostly not life-threatening.

Food Allergy

These are severe immune reactions to certain foods due to increased immunoglobulin E (IgE) production.

The symptoms of food allergy usually occur within 2 hours of eating the food and may include:

Food allergies can result in anaphylactic reaction, which is a life-threatening complication.

FeatureFood AllergyFood IntoleranceFood Sensitivity
InvolvementImmune system (IgE response)Digestive systemImmune response (non-IgE)
Symptoms OnsetRapid (minutes to hours)Delayed (hours to days)Delayed
SeverityPotentially life-threateningGenerally less severeVaries
Common ExamplesPeanuts, shellfishLactose intoleranceGluten sensitivity

What Causes Food Sensitivity?

Food sensitivity occurs when the body launches an immune reaction against a food that has been ingested.

It does so by producing antibodies.

Food sensitivities typically result from a combination of digestive issues, gut health, and environmental factors.

Here are some key causes:

Gut Health And Microbiome

Research suggests that gut microbiome imbalances can influence immune function and may contribute to adverse food reactions.

For example, conditions such as leaky gut syndrome, where the intestinal barrier becomes permeable, may allow undigested food particles to enter the bloodstream, triggering immune responses and sensitivities.

Environmental Factors

Stress, medications (like antibiotics), and poor dietary habits can contribute to or exacerbate food sensitivities.

Diets high in processed foods and low in fiber can reduce microbiome diversity and impair immune function.

Over time, this may predispose individuals to various intolerances or sensitivities.

Genetic Predisposition

There is a genetic component to food sensitivities.

Individuals with a family history of allergies or intolerances may be more prone to developing similar issues themselves.

Can Food Sensitivity Go Away?

The best way to deal with food sensitivity is to avoid the food causing the symptoms.

In some cases, the food sensitivity may go away with time.

But do all food sensitivities go away? Well, there is no definitive answer to that!

An infographic explaining everything you need to know about a food sensitivity test

What Is A Food Sensitivity Test?

Food sensitivity tests measure the body’s immune response to certain foods.

During food sensitivity, the body produces IgG, IgM, and IgA, as well as white blood cells and other immune system molecules to interact with and react to the consumed foods.

These can be measured to confirm sensitivities to food items.

How To Take A Food Sensitivity Test At Home

Besides lab tests, several companies today offer at-home food sensitivity testing that claims to help an individual gain better insight into the foods that may be causing uncomfortable digestive symptoms.

You will require a testing kit to test for food sensitivities at home.

Depending upon the test kit, you will need to submit a sample of one of the following:

Different at-home testing kits provide specific instructions on how to perform the test.

You must collect the sample after you have been exposed to food allergens.

Most companies provide their results within a few days to weeks.

Who Should Get A Food Sensitivity Test?

Food sensitivity tests are recommended for people with:

Who Should Not Get A Food Sensitivity Test?

One must always get a food sensitivity test after eating the food they suspect they are sensitive to.

So, people with eczema or severe food sensitivity must avoid this test.

Where Can I Get A Food Sensitivity Test?

There are several at-home food sensitivity tests that you can try. Here’s a quick comparison of the most popular ones.

EverlyWell Food Allergy TestLabcorp Food Allergy TestQuest Food Allergy Test Panel
Pricing$149$199$179
Global availabilityAvailable in the USA and some online retailersAvailable in the USA and some online retailersAvailable in the USA and some online retailers
ReviewsPositive: The company has received positive reviews from consumers who report that their home-testing experience is easy and that they received the results quickly.
Negative: A few negative feedbacks include: difficulty in collecting enough blood, delayed processing of reports, loss of reports, difficulty in reaching customer care, concerns about test accuracy 
This is one of the few tests that are CLIA-approved and allow for mailing the samples. The results are available digitally but take longer than those of the competitors.There are limited reviews about Quest Diagnostics’ food allergy test The company is still
OpinionThis is one of the few tests that are CLIA-approved and allow for mailing the samples. The results are available digitally but take longer than those of the competitors.Though it is the most expensive home food sensitivity test, it detects about 12 foods that can trigger an allergic reaction.While this test measures around 15 foods, the doctor must pay an additional fee to review the results. Patients are also supposed to go to give their blood samples, which makes it tedious compared to other home test kits. 

Are Food Sensitivity Tests Reliable?

The American Academy of Allergy, Asthma & Immunology (AAAAI) states that the presence of IgG in blood samples tested by home kits is not a reliable identifier for food allergens.

Increased IgG levels may also result from a normal body response to food exposure.

Some research states that food sensitivity tests that rely on genetic testing are not accurate enough for diagnostic use.

Here's why:


While traditional food sensitivity tests have their limitations, exploring your genetic predispositions can offer valuable insights into how your body might react to certain foods or drugs.

At Xcode Life, our Allergy and Drug Sensitivities Report uses your existing ancestry test raw DNA file to provide an added layer of information about your potential sensitivities.

Rated 4.7/5 By Users Like You


What To Do Instead Of A Food Sensitivity Test?

Since food sensitivity tests are not reliable to determine if you are allergic to specific foods, your doctor will perform a comprehensive evaluation, which may include:

FAQs About Food Sensitivity Tests

How Legitimate Are Food Sensitivity Tests?

While some tests, like IgG antibody testing, claim to identify food sensitivities, they are not always scientifically validated. 

Many practitioners prefer an elimination diet under their supervision as a more reliable method to identify sensitivities.

Is It Worth Doing A Food Sensitivity Test?

The value of a food sensitivity test depends on your symptoms and goals. 

These tests might provide a starting point if you're experiencing unexplained digestive issues, migraines, or fatigue.’

While these tests provide a starting point for unexplained digestive issues, fatigue, or migraines, their results may be inconclusive or lead to unnecessary dietary restrictions. 

How Much Does It Cost To Get A Food Sensitivity Test?

The cost varies widely depending on the type of test and provider/company. 

Food sensitivity tests start at $100 and can reach around $300.  

Some comprehensive and advanced lab tests, like Zoomer panels, may cost $400 to $600.

Check with your provider to see if the test is covered by insurance.

What Is A Zoomer Test?

A Zoomer test is an advanced diagnostic tool for detecting food sensitivities, intolerances, and cross-reactivity at a detailed level. 

These tests analyze peptides (small protein fragments) rather than whole proteins, giving you more precise results. 

Summary: Food Sensitivity Test

  1. Food sensitivity is an immune reaction to food and is driven by antibodies like immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA).
  2. Common food tolerances include dairy, gluten, caffeine, salicylates, and FODMAP groups.
  3. While the best way to deal with food sensitivity is to avoid the trigger foods, some people may notice their sensitivity improves with time.
  4. Food sensitivity tests detect the presence of immunoglobulins IgG, IgM, or IgG when consuming a suspected food item.
  5. Several at-home and in-clinic food sensitivity tests can help you learn more about your allergies to certain foods.
  6. Food sensitivity tests, particularly those based on IgG antibody levels, are generally considered unreliable and not supported by substantial scientific evidence.
  7. People with allergy symptoms, family history of food allergies, and chronic gastrointestinal symptoms must take a food sensitivity test.

Check Your Gene Variants For Lactose Intolerance

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References

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