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The MTHFR gene is key to a process called methylation, which pretty much runs the entire show in our human body, regulating innumerable critical functions. The importance of a well-functioning methylation cycle, thus, cannot be overstated. But when there are unfavorable changes in the MTHFR gene, methylation could be affected, increasing your risk for numerous health conditions. A genetic methylation test is a simple way to identify whether or not you carry the MTHFR gene changes. Well, what if you do? The fix is as simple as it gets. Read on to learn more about MTHFR and methylation, how to get a genetic methylation test, and ways to combat MTHFR mutations.
Methylation is a critical biochemical process within the human body, governing myriad functions from DNA production to brain chemical synthesis.
This intricate process is vital in regulating key bodily systems, including cardiovascular, neurological, reproductive, and detoxification pathways.
At its core, methylation is about turning biological gears and switches on and off, enabling the body to function optimally.
Central to this process is the MTHFR gene, which encodes for the enzyme methylenetetrahydrofolate reductase.
This enzyme is instrumental in processing amino acids, the fundamental building blocks of proteins. MTHFR's significance is particularly pronounced in a chemical reaction involving different forms of vitamin B9 (folate).
This reaction is a crucial step in the methylation process.
The MTHFR enzyme also aids in converting homocysteine into methionine, an essential compound needed by the body for protein synthesis and the formation of other critical substances.
In the study of genetics, a variant refers to any deviation in the DNA sequence from what is typically expected.
Focusing on the MTHFR gene, each individual carries two copies of this gene, inheriting one from each parent.
Approximately 40% of the adults carry at least one mutation or variant in the MTHFR gene, which leads to less than optimal enzyme activity.
The two common variants in the MTHFR gene are:
The presence of these variants can lead to elevated levels of homocysteine in the blood.
Homocysteine is an amino acid that, at high levels, may be associated with a range of health issues, including:
Understanding the possible genotypes for these MTHFR variants is crucial in determining an individual’s genetic predisposition to these health issues.
The methylation pathway in our bodies is influenced by many genes. The most important one is the MTHFR gene. Others include:
A methylation genetic test analyzes these genes associated with the methylation pathway to look for any changes or variants that may result in less-than-optimal functioning.
The results can help you understand your methylation status and underline nutritional needs to support your methylation.
A genetic methylation test typically costs between $200 and $500, depending on the specific panel and lab used.
However, some DNA analysis companies let users upload their existing raw DNA files to avail the methylation report for a lower cost.
More comprehensive tests that include blood biomarkers, etc, can cost up to $1,000.
The following are some popular choices for a genetic methylation test.
| Company | Test | Price |
| Xcode Life | 15 gene panel, 60 variant methylation report | |
| StrideDNA | 19 gene panel | |
| LifeDNA | 12 gene panel | $249 |
| 10X Health System Gary Brecka | ~5 methylation genes | $599 |
Clinical methylation tests will mostly require a visit to the lab, where a clinician will provide guidance.
You can find your nearest lab here.
Many direct-to-consumer genetic testing companies also offer genetic methylation tests.
Some ship out DNA kits, which you can collect your sample and ship back. Some areas may be unserviceable.
Services like Xcode Life allow you to upload your existing ancestry test raw DNA file to provide a comprehensive methylation report.
The best part? You can do it from anywhere in the world.
The Xcode Life Methylation Genetic Test utilizes raw data obtained from popular ancestry genetic testing service providers like 23andMe, Ancestry DNA, Family Tree DNA (FTDNA), Living DNA, and My Heritage to provide the MTHFR and Methylation report.
The test analyzes more than 15 genes associated with the methylation pathway.
The test specifically detects two common mutations in the MTHFR gene:
The MTHFR Report will indicate whether these mutations were detected in the individual’s genetic data.
In addition to the detection of mutations, the report also provides an interpretation of the results.
The report has a section titled “Other Methylation Genes,” which profiles your genotypes for variations in the other methylation genes, which are associated, in varying degrees, with methylation.
| Other Methylation Genes | ||||
| MTR | COMT | AHCY | SHMT | CTH |
| MTRR | NOS3 | MTHFD1 | CBS | MAT1A |
| BHMT | MAO-A | GNMT | CPS1 | MTHFR |
For a sample MTHFR report/ preview of the report, click here.
Did You Know?
The DNA data from your genetic ancestry test can be used to identify if you have MTHFR gene mutations. You can discuss these results with your doctor, who can recommend the correct course of action for you. Download your DNA data and upload it to Xcode Life to learn about MTHFR and 1,500+ things about your health.
Katy Says
I’m so glad I confirmed once and for all about my MTHFR status. The genetic testing my practitioner offered was extortionate. After completing my AncestryDNA, I was able to upload my raw data file with Xcode Life at a very reasonable price and receive a report that was very easy to understand. I now have a concrete plan on how to go about lowering my homocysteine and checking it’s status every year... Read More.
In Xcode Life’s MTHFR report, the initial section will specify which, if any, of the 2 prominent variants of the MTHFR gene you have.
Depending on the results, the MTHFR enzyme activity will be provided as a bar diagram.
If the pointer is in orange or red, please discuss the results with your doctor so that they can correlate them with family history and clinical symptoms to recommend suitable supplementation if you require any.
The next section of the report includes information on variants in other genes that partially influence MTHFR enzyme activity.
The presence of a large number of homozygous (2 risk variants- red color) of high-ranking SNPs may be associated with lower enzymatic activity.
Improving methylation, a crucial biological process, can significantly impact overall health. Here are five natural ways to enhance methylation:
Bonus Tips
Additional strategies include increasing the intake of coenzyme Q10, phosphatidylcholine, folic or l-methylfolate, and vitamins B6 and B12, which are integral to the methylation process.
Maintaining gut health, improving stomach acid, and supplementing with antioxidants, magnesium, and zinc can also support proper homocysteine metabolism.
Remember, while these natural approaches can improve methylation, it's crucial to consult with a healthcare provider for personalized advice, especially regarding supplementation and diet modifications.
Methylation is a vital biochemical process in our bodies, influenced significantly by the MTHFR gene and its two important variants, C677T and A1298C.
These common genetic mutations, found in a significant portion of the population, can lead to elevated homocysteine levels and associated health risks.
The Xcode Life Methylation Genetic Test offers an in-depth analysis of these variants using data from popular ancestry testing services. It provides a comprehensive MTHFR report, helping individuals understand their genetic predisposition to methylation-related issues.
To support optimal methylation, adopting a nutrient-dense diet, supplementing appropriately, regular exercise, adequate sleep, limiting exposure to harmful substances, and reducing toxin exposure are key strategies.
Additionally, incorporating specific nutrients and supplements like coenzyme Q10, phosphatidylcholine, folinic acid, and vitamins B6 and B12 can further enhance methylation processes.
It's important to consult with healthcare professionals for personalized guidance and to ensure these natural methods align with your individual health needs.
https://www.nature.com/articles/npp2012112
https://www.medicalnewstoday.com/articles/326181
https://www.cdc.gov/ncbddd/folicacid/mthfr-gene-and-folic-acid.html
A vegan diet may have several benefits, such as reducing the risk of diabetes and heart and kidney disease and helping people lose weight. However, an unplanned vegan diet can result in nutritional deficiencies. In fact, some nutrients essential for the body are only found in animal products. In this article, we discuss whether vegans can be low on vitamin E and other nutrients and how to counter it.
Vitamin E falls under the group of fat-soluble vitamins.
This group also has vitamins A, D, and K besides vitamin E.
These vitamins play an important role in bodily functions and are best absorbed when taken with dietary fats.
Vitamin E, in particular, is an antioxidant.
This means it prevents free radical damage in your body and protects your cells.
Free radical damage can cause deadly diseases like cancer.
Vitamin E also supports metabolic functions, the immune system, gene expression, and cell signaling.
Daily dietary requirements of vitamin E can vary.
According to Australia's Nutrient Reference Value, these are the daily dietary dosages of vitamin E required in different groups of the population:
| Age Group | Vitamin E Requirement |
| Infants: less than 12 months old | 4-5 mg/day |
| Children: 1-10 years old | 5-8 mg/day |
| Adolescents: 14-18 years old | 8-10 mg/day |
| Adults: Above 19 years | 7-10 mg/day |
| Those who are pregnant and breastfeeding | 8-11 mg/day |
Vegans are usually not at a greater risk of being low on vitamin E.
Vitamin E is a fat-soluble vitamin that is stored in the body.
This means your body has a reserve of vitamin E that can be used when you run low on this nutrient.
Many foods included in a vegan diet, such as vegetable oil, nuts, seeds, and whole grains, are good sources of vitamin E.
Vitamin E deficiency can occur if you have a genetic condition or a chronic disease that makes uptake of vitamin E difficult or if you eat a diet that is extremely low in fats.
Liver diseases, gallbladder diseases, and pancreatitis are some diseases that cause malabsorption of fats.
This can lead to vitamin E deficiency in the body.
You might notice these symptoms if you have a deficiency of vitamin E:
Vitamin E supplements are generally not recommended for vegans and non-vegetarians.
For those who don't have any absorption issues, vitamin E requirements can easily be met through a balanced diet that includes healthy fats.
A diet that includes unsaturated fats and oils can help vegans meet their daily vitamin E requirements.
Vitamin E supplements can result in toxicity since this is a fat-soluble vitamin stored in the body.
Vitamin E has a blood thinning effect.
This means that supplements might be dangerous for people who are on blood-thinning medications like Warfarin.
Too much vitamin E can reduce blood clotting time and result in excess bleeding.
If you want to start taking vitamin E supplements, it is best to consult your doctor first.
Did You Know? Even if you are on a healthy diet, you might be at risk for nutritional deficiencies due to hidden genetic variants that impact nutrient metabolism. This is why many people feel tired and are on low energy most of the time.
Vitamin E is found in several plant products, fruits, and vegetables.
| Food Item | Serving Size: Vitamin E Content |
| Sunflower seeds (dry roasted) | 1 ounce: 7.4 mg |
| Hazelnuts (dry roasted) | 1 ounce: 4.3 mg |
| Wheatgerm oil | 1 tablespoon (20 mg) |
| Avocado | Half a fruit: 2.1 mg |
| Broccoli (boiled) | ½ cup: 1.1 mg |
| Mango | ½ cup sliced: 0.7 |
Apart from vitamin E, here are a few more nutrients that are hard to get on a vegan diet:
Vegans are usually deficient in the following:
Some vegan-friendly foods that are rich in vitamin E are:
Vitamin E deficiency can cause infertility in both males and females.
This nutrient protects cell membranes.
In men, vitamin E deficiency can lead to low sperm count, poor sperm motility, and poor semen quality.
In females, vitamin E deficiency can cause eclampsia, premature delivery, and miscarriage.
Vitamin E deficiency can show certain symptoms, which can help you understand that you might be deficient in this nutrient.
If you experience muscle weakness, fatigue, mental confusion, and depression, you might be deficient in vitamin E.
However, having these symptoms can also indicate the presence of other disorders.
That's why it is best to consult your healthcare provider to determine whether you are suffering from low vitamin E levels.
Vitamin E is a fat-soluble vitamin that plays a vital role in the body's normal functioning.
Most people are not deficient in this nutrient since it is widely found in various food items, and the excess is stored in the body as a reserve.
Vegans are not at an increased risk of deficiency since vitamin E is found in many plant-based foods such as nuts, seeds, oils, and whole grains.
Those who suffer from a vitamin deficiency have an underlying condition or disease.
However, vegans can be deficient in other nutrients such as vitamin B12 and vitamin D.
Taking supplements can help counter this.
However, it is always recommended that you consult a doctor before starting any supplements.
Paleo vs. Keto Diet: Which Is Better For Weight Loss?
The Ultimate Guide To Anti-inflammatory Diet + Food List PDF
https://www.sciencedirect.com/science/article/pii/S0261561420306567
https://journals.eco-vector.com/1560-9596/article/view/112972
https://pubmed.ncbi.nlm.nih.gov/21947532
Searching for a sugar substitute that won't compromise your health? The market is filled with options, but it can be overwhelming to choose the right one. Today, we're shedding light on the debate - Truvia vs stevia, two natural sweeteners that have gained popularity. Join us as we uncover the truth about these alternatives and discover which might be the healthier choice for your sugar cravings.
Many people today prefer a low-sugar, no-sugar, or no-carb diet due to the adverse effects of sugar consumption.
Sugar is a type of carbohydrate, just like fiber and starch. There are different types of natural sugars.
For example, sucrose is a natural sugar found in fruits, vegetables, grains, and even dairy products.
Other natural sugars include:
Sugars, in moderate quantities, are essential for the body.
While natural sugars are healthy for you, consuming foods with added sugars can cause high blood sugar, insulin resistance, obesity, heart issues, and dental cavities.
Finding a sugar alternative today is relatively easy; however, it is important to understand why we need them.
Sugar substitutes are synthetically prepared or plant-based substances used to sweeten food or enhance the flavor of food and beverages.
Sugar substitutes can be of 3 types:
Artificial sweeteners: Zero-calorie sugar substitutes that do not contain sugar or any beneficial nutrients, are usually produced in laboratories, and are regulated by the FDA.
Examples: Neotame, aspartame, saccharin, sucralose, acesulfame potassium (Ace-K), advantage
The World Health Organization’s cancer research arm has labeled aspartame a “possible carcinogen.” A committee of 25 international experts has determined that aspartame may "possibly" cause cancer in people. There are several views about the safety of artificial sweeteners. Some experts believe these sweeteners pose health hazards. Studies are ongoing to determine the health risks of artificial sweeteners on humans.
Sugar alcohols: Synthetic compounds similar to artificial sweeteners but are not as sweet. They are added to foods for enhanced texture and taste but may cause gastrointestinal irritation, bloating, gas, and diarrhea.
Examples: Maltitol, sorbitol, xylitol, isomalt, lactitol
Novel sweeteners: Sugar substitutes derived from natural sources that are calorie-free, thus not leading to weight gain or spikes in blood sugar levels.
Examples: Stevia, allulose, monk fruit
A Harvard study identified three sugar substitutes to be associated with health risks:
Stevia and monk fruit are “generally regarded as safe,” which means they are safe to consume.
Stevia is an all-natural, calorie-free sweetener derived from Stevia rebaudiana (a herb).
The herb contains rebaudioside A, the sweetest compound in the stevia leaf.
The FDA has labeled rebaudioside A as ‘generally recognized as safe (GRAS).’
Stevia is a versatile sweetener that can be used as a sugar substitute in cooking, baking, and preparation of beverages.
Compared to regular table sugar, stevia is way sweeter, and some people complain of a slightly bitter aftertaste.
Here are a few pros and cons of stevia:
| Pros | Cons |
| Vegan and vegetarian-friendly | Costlier than regular sugar |
| Provides sweetness with zero calories | Not all products contain pure stevia |
| Gluten-free, non-GMO | Difficult to bake with |
| Better for the environment |
Truvia is the brand name for a sugar alternative launched by the Cargill company in 2018.
It combines stevia leaf extract with erythritol (sugar alcohol) and added flavors.
The 3 g of carbohydrate in Truvia comes from erythritol.
But, since the body does not absorb this alcohol, Truvia is said to be zero calories.
| Pros | Cons |
| Gluten-free Organic and non-GMO | Costlier than sugar |
| Provides sweetness without calories | Known to cause gastrointestinal issues |
| Taste and texture similar to sugar | Some people complain of an unpleasant aftertaste |
A few health benefits of Truvia include:
May have anti-diabetic and anti-hyperglycemic effects
Erythritol is believed to have anti-diabetic and anti-hyperglycemic effects.
Since this sugar alcohol does not cause a rise in insulin levels or blood glucose levels, it may be a good sugar substitute for people with diabetes and prediabetes.
May improve dental health
Since Truvia does not contain sugar, it may reduce the incidence of tooth decay and cavities.
Research states that erythritol prevents the growth of Streptococcus mutans, a bacterium known to cause dental decay.
Some studies state that erythritol may have antioxidant properties.
| Stevia | Truvia | |
| Calories | 0 | 0 |
| Carbs | 1 g | 3 g |
| Fat | 0 g | 0 g |
| Protein | 0 g | 0 g |
| Fiber | 0 g | 0 g |
| Sodium | 0 mg | 0 mg |
| Vitamins and Minerals | 0 mg | 0 mg |
| Added sugar | nil | Erythritol (sugar alcohol) is added to stevia to make Truvia |
| Glycemic Index | 0 | 0 |
| Taste | Stevia liquid extract is considered to be 15 to 30 times sweeter than table sugar. Stevia powder is 200 to 300 times sweeter than sugar. | Sweeter than stevia. |
| Benefits | May be beneficial for glucose and insulin response May prevent dental caries May have a blood pressure-lowering effect | May have anti-diabetic and anti-hyperglycemic effects May improve dental health May have antioxidant properties |
| Side Effects | Some people may develop an allergy to stevia. | May impact gut health in some individuals May cause laxative effects May cause bloating, stomach pain, and gas, especially in people with irritable bowel syndrome (IBS) |
A joint statement by the American Heart Association and American Diabetes Association said that stevia and a few other sugar substitutes may benefit people with diabetes.
However, they must be used in recommended amounts.
A few health benefits of stevia for people with diabetes include:
A 2016 study found that stevia leaf powder significantly lowered blood sugar levels in people with diabetes (fasting and post-prandial levels).
Like stevia, Truvia does not cause a rise in blood sugar levels, making it a safe sugar substitute for people with diabetes.
If you have diabetes or prediabetes or wish to manage your blood sugar levels, ask your doctor for the best possible sugar substitute.
Even though Truvia contains stevia, many nutritionists pick stevia as the better and safer option for consumption.
This is because stevia is less processed than Truvia and does not contain sugar alcohol like erythritol, which may cause gastrointestinal side effects.
Truvia’s erythritol content (a sugar alcohol) can cause digestive issues like bloating or diarrhea in some people, especially if consumed in large amounts. Additionally, Truvia is a processed product combining stevia extract with other ingredients, which may not appeal to those seeking a less refined sweetener.
There’s no one-size-fits-all “healthiest” sweetener. Plant-based options like stevia and monk fruit are generally recognized as safe and contain few or no calories. However, experts often emphasize using any sweetener in moderation and focusing on an overall balanced diet.
Highly purified stevia extracts are considered safe by the FDA, but whole-leaf or crude stevia is not approved for widespread use due to concerns about its possible effects on blood sugar, reproductive systems, and more. Some people also report a bitter or metallic aftertaste.
Is monk fruit better than stevia?
Both monk fruit and stevia are zero- or low-calorie sweeteners derived from plants. Evidence suggests neither is universally “better” than the other; it often comes down to personal taste, tolerance, and how each sweetener fits into an individual’s overall diet.
Stevia, monk fruit, and erythritol-based blends can all reduce added sugar in coffee. However, many health experts recommend gradually scaling back any sweetener to help reset taste preferences and encourage a more balanced diet overall.
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Is Coffee And Protein Powder Combination Safe? Experts Weigh In
NMNH (reduced nicotinamide mononucleotide) is a reduced form of the popular supplement nicotinamide mononucleotide (NMN). Both molecules boost the function of NAD+ (nicotinamide adenine dinucleotide), a coenzyme that helps energize you by regulating cellular processes. NAD+ levels decline with age, leading to age-related health issues. New research suggests that NMNH could boost NAD+ levels better than NMN can. If true, NMNH supplements could be a game changer to ward off age-related health infirmities. Here's what you need to know about them.
NMNH and NMN are both supplements that help boost NAD+ levels, but there are notable differences in how they work:
| Feature | NMN | NMNH |
| NAD+ boost | Moderate increase | Nearly 10x higher increase |
| Response time | Slower | Rapid, within 15 minutes |
| Lasting impact | Short | Last up to 24 hours |
| Dosage efficiency | Higher doses needed | Minimal dose sufficient |
| Tissue impact | Limited to certain tissues | Works across multiple tissues |
| Health benefits | Basic support for aging and cells | Stronger support for cellular health and aging |
| Absorption | Standard | More efficient due to reduced form |
| Energy and metabolism | General support | Extended energy and metabolism boost |
| DNA repair | Moderate | Enhanced |
Upon ingestion, NMNH is absorbed and converted into NAD+ through the action of nicotinamide mononucleotide adenylyltransferase (NMNAT).
As NAD+ naturally decreases with age, cellular function and efficiency can decline.
Increasing NAD+ levels with NMNH helps support crucial processes like energy metabolism, DNA repair, and cellular maintenance.
This increase in NAD+ can help mitigate age-related declines in cellular function, promoting healthier aging at the cellular level.
NMNH is being studied for its ability to combat age-related decline, showing potential benefits at both cellular and systemic levels, such as:
While NMNH supplements are generally considered safe for most individuals, some may experience side effects, including:
NMNH should also be used cautiously by individuals with certain medical conditions, such as:
Note: Before starting NMNH, it's advisable to check with a healthcare provider, especially if you have any health conditions.
Nicotinamide riboside (NR) and NMNH are NAD+ precursors, yet they vary in chemical structure, metabolic pathways, and physiological effects.
Upon ingestion, the enzyme nicotinamide riboside kinase converts it into NMN, which then enters the NAD+ biosynthesis pathway.
It can be directly used in the NAD+ biosynthesis pathway without converting to NMN.
A 2021 study highlights that NMNH is more effective than NMN in boosting NAD+ levels.
Lab tests and studies on mice showed that NMNH increased NAD+ levels more efficiently in both cases.
Additionally, NMNH increased NADH, the reduced form of NAD+, which is essential for cell energy production.
It also impacted metabolism by slowing down key energy pathways, such as glucose breakdown and the citric acid cycle, to improve cellular health.
In lab experiments, NMNH caused cell cycle arrest and inhibited cell growth, while no significant change in mouse weight was observed.
While both NMN and NMNH enhance NAD+ levels, NMNH's effects may offer superior benefits for health and aging.
The FDA has banned NMN under the "drug exclusion clause" of the Federal Food, Drug, and Cosmetic Act (FD&C Act).
According to section 201(ff)(3)(B) of the Act, any substance classified as an approved drug or tested as a new drug cannot be marketed as a dietary supplement.
Since NMN underwent clinical investigations before being sold as a supplement, the FDA determined it didn't qualify as a dietary supplement and banned it in the U.S. market.
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https://www.uthpeak.com/blog/what-is-nmnh-matter-for-your-health
https://www.uthpeak.com/nmnh-vs-nmn
https://downloads.regulations.gov/FDA-2023-S-0023-0084/attachment_1.pdf
https://www.healthline.com/health/nmn-nicotinamide-mononucleotide-benefits-side-effects-and-dosage
https://pmc.ncbi.nlm.nih.gov/articles/PMC6145238
https://pmc.ncbi.nlm.nih.gov/articles/PMC7384296
https://pubmed.ncbi.nlm.nih.gov/33793246
https://www.fda.gov/media/131878/download
Experiencing bloating and tiredness after meals? Does your stomach ache, or do you find it hard to concentrate after eating certain foods? There might be a hidden cause – lectins. Though found in many healthy foods, lectins can cause problems for some people, like tummy troubles, skin issues, and feeling worn out. Keep reading to learn about lectins, which foods have lots of them, signs to watch for, and most importantly – what you can do if they're making you feel unwell. If you want to take charge of your health and feel better, this article gives simple tips and useful information about dealing with lectins.
Did You Know?
Certain gene changes can make you prone to food intolerance and drug allergies. These genes are mostly involved in immune system regulation, and changes in them may result in the immune system attacking some components in the food. You can use your ancestry genetic testing data to uncover this information. Learn more.
Lectin intolerance is a food sensitivity that occurs when certain people react badly to foods with lots of lectins.
Lectins are proteins in plants like beans, grains, fruits, and vegetables. They stick to carbohydrates in our guts, messing with how we absorb nutrients and causing digestive discomfort.
Lectins are stable in acidic environments, which is a protective feature for plants. However, this means that it is not easily broken down in the gut.
Hence, while lectins may be fine for most people, some might experience adverse reactions or other symptoms after consuming them.
Lectin intolerance can cause various symptoms, highlighting the significant impact on overall health and well-being.
Several commonly consumed foods have high levels of lectins. Here are 6 examples:
Adding to the list of foods already mentioned above as high in lectins, here are some more examples:
Understanding what might increase the risk of lectin intolerance is crucial for managing symptoms. Here are some potential factors:
The specific genes associated with lectin sensitivity are still being studied, but two genes might be involved:
Remember, lectin sensitivity involves many genes and other factors, and research is still ongoing to understand it better.
Bananas contain moderate lectins, but they are mostly harmless, called agglutinins. The human gut does not readily absorb these agglutinins, and they do not cause significant health problems for most people.
While coffee does contain lectins, the amount is generally considered low and not thought to be harmful to most people. Some studies suggest that coffee may have some health benefits, like lowering the risk of neurodegenerative diseases and type 2 diabetes.
There is no known way to flush lectins out of your body. Here's why:
Lectins do not negatively impact everyone. While some people may develop symptoms after eating lectin-containing foods, others can tolerate them without issue.
It's important to note that responses vary on an individual basis. Testing your sensitivity to lectins is essential.
Additionally, foods with lectins offer health benefits like antioxidants, stabilized insulin, and blood sugar regulation.
Research shows populations eating diets high in lectin-rich legumes, whole grains, and nuts have lower rates of cardiovascular disease and type 2 diabetes.
So, while lectins can cause problems for some, they also provide benefits.
It's best to consult a professional to determine if you can incorporate lectin-rich foods in moderation as part of an overall balanced approach.
Managing lectin intolerance involves alleviating symptoms rather than curing the underlying condition.
As many reported symptoms involve gastrointestinal distress, reducing or eliminating high-lectin foods from one's diet may provide relief.
Restricting the consumption of foods that worsen symptoms under a healthcare professional's instructions can help manage discomfort.
The goal is to identify and minimize the consumption of specific high-lectin foods that cause symptoms in each individual.
This personalized approach helps tune into the body's signals, control flare-ups, and improve overall wellness.
Reducing lectin intake can help alleviate discomfort for those sensitive to these compounds.
Here are some straightforward ways to lower your lectin consumption:
Note: It's best to consult a healthcare provider for personalized guidance, considering your health history and symptoms.
Lectin intolerance can cause digestive issues, fatigue, and brain fog in some individuals.
While lectins are found in various healthy foods, they can trigger reactions in sensitive individuals.
These plant proteins can bind to gut carbohydrates, potentially impacting nutrient absorption and causing discomfort.
Bloating, nausea, diarrhea, brain fog, anxiety, fatigue, skin issues, and disrupted sleep are potential signs of lectin intolerance.
Examples of high-lectin foods include red kidney beans, soybeans, wheat, peanuts, tomatoes, potatoes, and others.
Frequent antibiotic use, gut imbalances, leaky gut, plant-based diets high in lectins, and certain genes might increase the risk.
To reduce lectins, you can boil, soak, sprout, or choose processed beans. Depending on your sensitivity, you may also need to adjust your diet.
https://www.hsph.harvard.edu/nutritionsource/anti-nutrients/lectins/
https://www.healthline.com/nutrition/foods-high-in-lectins
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084985/
https://www.healthline.com/nutrition/dietary-lectins
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960708/
https://pubmed.ncbi.nlm.nih.gov/21892520/
https://www.ncbi.nlm.nih.gov/books/NBK5968/
https://pubmed.ncbi.nlm.nih.gov/11030554/
https://pubmed.ncbi.nlm.nih.gov/29590460/
In an ever-changing world, what if we told you there was technology that could analyze an individual’s gut biology and gain insights into their health? The friendly bacteria in your gut can help strengthen immunity and influence cognitive abilities. Gut bacteria also affect your risk for certain brain diseases, such as Alzheimer’s disease, Parkinson’s disease, and autism. That’s what Viome, a health testing company in the United States, has set out to develop! Let's take a look at Viome reviews, highlighting what the internet has to say about them, and add our own two cents.
Viome is a health health testing company that uses mRNA (mitochondrial RNA) samples to identify the microbes in an individual’s gut.
With an in-depth gut microbiome analysis, the company allows individuals to identify their risk for chronic diseases and other health concerns, such as cancer and aging.
Viome offers personalized recommendations for nutrition, supplements, and precision therapeutics based on the test results.
The company's headquarters is in Washington, United States.
Most companies that offer microbiome testing use a person’s stool sample.
There are two types of fecal testing that a company may offer–
Here’s what a typical microbial testing looks like:
Viome uses AI and RNA sequencing to identify and quantify microbes.
These techniques can study various strains of viruses, bacteria, yeast species, and other parasites.
Viome test analyses how microbes function and the metabolites they produce.
The results are then used to control an individual’s gut microbiome and reduce the risk for chronic diseases.
The company claims to do this by offering food, lifestyle, and supplement recommendations tailored to an individual’s needs based on their test results.
Viome offers the following products:
A person provides blood or stool samples for this test to analyze their gut microbiome and gene expression.
The scores help individuals measure their stress, immune response, and mitochondrial and cellular health.
These scores also determine the person’s biological age and if it is the same as their chronological age.
This test requires a stool sample to assess gut microbiome health.
The individual receives a dietary recommendation chart with foods and supplements that they can benefit from and help optimize their gut health.
Based on test results, each individual receives a personalized and precise recommendation for supplements, including vitamins, food extracts, minerals, herbs, and probiotics.
These nutrients are formulated on demand and can be shipped directly to the individual every month.
Viome’s personalized probiotic and prebiotic formulas promote microbial richness and diversity, supporting gut health and total body wellness.
Viome offers a one-time purchase of tests and also allows plans on a subscription.
The subscription plans may include probiotic and prebiotic supplements and annual tests.
Once you book your test or subscribe to the annual plan, follow the instructions and send the required samples to the lab.
The test results will be available around four weeks after the lab receives the samples.
You can see your results online on the company website or the app.
Viome performs their test analyses at a CLIA-certified US laboratory in Bothell, WA.
The lab is certified to meet certain quality standards and ensure the accuracy and reliability of results.
There have been a few negative reviews about Viome due to the delayed test results.
Though many people have positively reviewed how a Viome test result has improved their health, more research is required to prove this.
Let’s dive deep into reviews and reports about how Viome may improve health.
Since all the authors of the above studies were employees of Viome and the company sponsored these studies, there is bias, and the results may not be reliable.
Our Take: While some studies have highlighted the effectiveness of Viome tests, these are limited in both quantity and scale. Substantial clinical research and validation will be needed before Viome can reliably support individuals in transforming their gut health and reducing their risk for chronic conditions.
The pricing of different Viome tests is given below:
| Type of Test | Price (in USD) |
| Full Body Health Solutions | $169.15/month |
| Full Body Intelligence Test (Test Only) | $299 |
| Gut Health Solutions | $67.15/month |
| Gut Intelligence Test (Test Only) | $279 |
| Oral Health Solutions | $67.15/month |
| Oral Health Intelligence Test (Test Only) | $259 |
| Precision Supplements | $126.65/month |
| VRx My·Biotics™ Gut Formula | $67.15/month |
| VRx My·Biotics™ Toothpaste & Gel | $67.15/month |
| CancerDetect Test for Oral and Throat Cancer | $599 |
There are several pros and cons that you must consider before opting to undergo a Viome test.
The Better Business Bureau has not accredited Viome.
However, it has given Viome an A+ rating.
The company has also resolved 52 complaints over the last 3 years.
However, the company scored 1.24 out of 5 stars from 59 customer reviews.
People who reported improvement in conditions such as irritable bowel syndrome and chronic obstructive pulmonary disease gave positive reviews.
Most negative reviews highlighted the following reasons:
While Viome has mixed reviews on Reddit, most people were unhappy with the company’s test, processing time, and results.
There is speculation that Viome themselves have pushed artificial positive reviews on Reddit.
Some customers are unhappy with the “unscientific” nature of the test results.
Some individuals have stated that their Viome test helped them better understand their body and gut health.
The affordability of Viome tests works in favor of the company as well.
The primary difference between Viome and EverlyWell is that Viome provides personalized dietary recommendations based on gut microbiome analysis.
Everlywell, on the other hand, provides general recommendations for improving gut health.
Since Viome offers personalized recommendations, they may be more effective in improving gut health.
Viome tests are not FDA-approved and, therefore, are not recommended for diagnosis of conditions.
However, Viome recently received an FDA Breakthrough Device Designation for its saliva tool, which can help screen for oral cancers.
After the lab receives the sample, it may take around 4 weeks for the results to become available online- on the company website or the app.
Here are a four few things to keep in mind before taking a Viome test:
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