What if addiction is less about the choices we make and more about the genetics we inherit? Research suggests that up to 50% of addiction risk may come from our DNA. Advances in genetic science are revealing how specific genetic variations might influence our susceptibility to addiction. This new understanding prompts us to question how much control we really have over addictive behaviors. Let’s explore the connection between genetics and addiction to uncover how our genes might shape our vulnerabilities.
Addiction can be influenced by genetics, with some people inheriting a predisposition to substance use disorders (SUDs).
Substances like alcohol, tobacco, and drugs are acted upon by certain genes which influence the following:
Some people may have certain genes that make them enjoy the drugs more than normal.
The genes may trigger the release of certain hormones that induce pleasure response upon substance usage.
Thus, they may make a person more prone to addiction.
However, it is important to note that genetics by itself cannot cause addiction.
It works alongside other factors to determine whether someone develops addictive behaviors.
Various genetic factors influence how the brain processes pleasure, stress, and reward.
Some of these increase susceptibility to addictive behaviors, particularly through their impact on dopamine and reward pathways.
Some genes linked to addiction include:
Drug addiction can have a hereditary component, meaning that if you have a family history of addiction, you may be more likely to face similar challenges.
Heredity plays a crucial role in addiction, with genetic factors contributing about 50% to the likelihood of developing SUDs.
Advances in genetic research, particularly through genome-wide association studies (GWAS), reveal that many small genetic variations influence SUDs.
These variations across the genome can increase addiction risk.
Findings have pinpointed specific genes related to alcohol metabolism, such as ADH1B and ALDH2, and nicotine use, such as CHRNA5–CHRNA3–CHRNB4.
These discoveries highlight how genetic predispositions can increase vulnerability to addiction, though they do not guarantee it.
A combination of genetic and environmental factors conditions addiction.
Genetics may predispose individuals to addiction, but environmental influences like stress, trauma, and peer pressure are equally important in shaping addiction risk.
However, having a supportive environment and developing healthy habits can help prevent addiction, even for those with a genetic risk.
There isn’t a single “addiction gene.” Instead, a combination of genetic variants may increase a person’s risk of developing addictive behaviors.
These genes can influence the brain’s reward system, particularly through dopamine.
Some individuals may inherit gene variants that heighten their susceptibility to addictive behaviors, making it harder to regulate impulses.
Genetic testing can reveal details about a person’s genes, including variations that might increase their risk of addiction.
These tests can identify specific genetic markers linked to addiction, helping individuals understand their potential vulnerability.
As research progresses, genetic testing is expected to become more accurate in identifying addiction risks. For now, the information from these tests allows people to assess their risk more clearly.
This understanding helps them make better lifestyle choices, seek support if needed, and take steps to reduce their risk.
Efforts like the National Institutes of Health’s (NIH) Big Data to Knowledge (BD2K) program are working to improve how genetic data is used and shared.
This research aims to refine genetic testing and develop personalized treatments based on genetic profiles.
Additionally, pharmacogenetics is an emerging field that customizes medications based on an individual’s genetics, potentially improving addiction treatment.
Research indicates that approximately 40% to 70% of an individual’s susceptibility to SUD can be due to genetic factors, particularly when there is a family history of addiction. Specific genes can influence how the brain’s reward system responds to substances, increasing the likelihood of developing dependence. People with a family history of alcohol abuse are up to 4 times more likely to develop problems with alcohol.
While genetics influence addiction risk, environmental factors, such as exposure to drugs at an early age and experiences of trauma or stress, also significantly contribute to an individual’s risk. Additionally, mental health issues like anxiety or depression can lead some individuals to self-medicate with substances, increasing their susceptibility to addiction. Ultimately, the interplay between these biological and environmental influences shapes each person’s unique vulnerability to developing substance use disorders.
Dopamine addiction appears as follows:
Even with a genetic predisposition, you can manage addiction by taking proactive steps and seeking personalized support.
Recognizing your triggers and developing strategies to handle them are crucial to lowering your risk.
Several ways to prevent and manage addiction include:
Signs of a genetic predisposition to addiction include:
Gambling Addiction Likely In The Genes, Study Says
How Genes Influence Impulsivity And Risk-taking Behavior
The Genetics Of Alcohol Dependence
https://health.clevelandclinic.org/is-addiction-genetic
https://americanaddictioncenters.org/rehab-guide/addiction-genetic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477224
https://learn.genetics.utah.edu/content/addiction/genes
https://nida.nih.gov/publications/drugfacts/understanding-drug-use-addiction
https://www.verywellmind.com/can-you-get-addicted-to-dopamine-5207433
Dimples, particularly those that emerge when smiling, hold a unique place in human aesthetics and cultural symbolism. Found in a significant portion of the world’s population, the genetic foundations of dimples still prompt curiosity and research. This article examines what gene causes these dimples, unraveling the mystery behind one of the most sought-after physical features.
Dimples are dips or small indentations that appear on the skin.
Humans can develop dimples in different body parts, like the cheeks, chin, or lower back. These are harmless indentations that are primarily physical.
Dimples, when they form on other parts of the body like the natal cleft, nose, limbs, or scalp, could be associated with certain medical conditions and must be diagnosed by healthcare providers.
There are two common types of cheek dimples – unilateral and bilateral.
Unilateral dimples occur on one side of the cheek, while bilateral dimples form on both cheeks.
A 2018 study analyzed the type of cheek dimples and concluded that 55.6% of the population had bilateral dimples.
In comparison, only 44.4% of the population had unilateral dimples.
Dimples are formed due to a slight change in the facial muscle bundle called zygomaticus major.
The zygomaticus major starts at the tip of the cheekbone and goes down to the corners of the mouth.
These muscles pull the corners of the mouth upwards when people smile.
Usually, the zygomaticus major is usually a single bundle of muscle on either cheek.
In some people, the muscle divides into two bundles – one half from the cheekbone to the middle of the cheek and the other half from the midpoint to the corner of the mouth.
When the skin moves over this split while smiling, a slight indentation appears, which is called a dimple.
Studies report that the global prevalence of genetically inherited cheek dimples is about 22.7%. In the American population, the number is higher, at 34%.
Dimples, particularly those that appear when smiling, are primarily influenced by genetic factors.
Very little research has actually been done on the specific genes responsible for cheek dimples.
These genes may be associated with variations in the zygomaticus major muscle.
Did you know that up to 34% of Americans, 27.4% of Asians, and 12.3% of Europeans are genetically inclined to develop dimples?
According to experts, specific gene changes could be why some people have two bundles of the zygomaticus major while others don’t.
These gene changes could be passed on in the family, making cheek dimples a heritable trait.
Did you know?
While we know that our DNA governs observable traits like eye color, height, and even dimples, not many of us are aware that it even influences health predispositions, altering our risk for many chronic conditions like diabetes and heart disease. Xcode Life allows you to upload your existing DNA data from ancestry tests to learn 1,500+ things about your health. Learn more.
Unless born with dimples, you may not be able to create the indentation naturally.
Some people may have excess fat on the cheeks, leading to the temporary formation of dimples. These dimples disappear when they lose the fat, though.
Dimpleplasty is a technique performed by a trained surgeon to create dimples on the skin.
Here, the surgeon marks where the dimple is needed and makes a small hole in the skin to remove muscles and fat underneath.
Now, the area is sutured using a sling. This process attaches the skin to the muscles to create the indentation.
It may not be possible to get rid of dimples naturally.
Using fillers like Botox on the area may loosen up the muscles and bring down the prominence of the dimple.
This procedure is only temporary and may need to be repeated every 2-3 months.
Dimples occur when the zygomaticus major muscle splits into two bundles, creating an indentation when people smile.
Dimples are genetically inherited. However, the exact genes that lead to the formation of dimples haven’t been identified yet.
Dimples on the cheeks, chin, or lower back are often harmless, while those in areas like the nose, limbs, or scalp could be due to medical reasons and must be checked by an expert.
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https://pubmed.ncbi.nlm.nih.gov/30807476/
https://pubmed.ncbi.nlm.nih.gov/24738724/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955629/
A revolutionary new health drink, or just another sugary health risk? Vitamin water is a new beverage that claims to be jam-packed with electrolytes, minerals, and vitamins. However, its actual impact on your health goes beyond the nutritional label on the bottle. This post explores expert opinions, studying this popular beverage’s potential benefits and downsides that you might not expect.
Vitamin water is a beverage made of water enriched with vitamins and minerals.
It may also be infused with some electrolytes.
Vitamin water comes in many flavors and is sweetened with sugar or sugar substitutes.
The formulation of vitamin water varies from brand to brand.
Vitamin water contains:
Not all brands or flavors necessarily contain all these ingredients.
The main difference between the normal and the Zero variants of vitamin water is that the latter has no added sugar.
The Zero variant is sweetened with artificial sweeteners like erythritol and stevia.
So, on average, the normal variant has 100 calories per bottle, while the Zero variant contains 0 calories.
In short, no. Vitamin water is not the best source of your daily vitamins and minerals. Its high sugar content and flavoring agents can also negatively impact your health.
Let’s break down the ingredients and look for the potential benefits of consuming vitamin water.
Coca-Cola put vitamin water on the map.
They offer it in normal and Zero variants.
The normal version contains 26 grams of sugar per bottle.
This is nearly half the recommended daily sugar intake, which is very unhealthy.
The Zero version has no added sugar and is thus a calorie-free drink.
While this is a healthier alternative, it may not be the best choice. We’ll get to the why of it shortly.
Flavor | % RDA of Vitamins and Minerals |
Açai Blueberry Pomegranate | Vitamin C: 50% Vitamin E: 100% Niacin (B3): 25% Pantothenic Acid (B5): 25% Vitamin B6: 20% Vitamin B12: – |
Tropical Mango | Vitamin C: 100% Vitamin E: 100% Niacin (B3): 25% Pantothenic Acid (B5): 25% Vitamin B6: 20% Vitamin B12: – |
Power-C Dragonfruit | Vitamin C: 200% Zinc: 25% Niacin (B3): 25% Pantothenic Acid (B5): – Vitamin B6: 20% Vitamin B12: – |
Focus Kiwi-Strawberry | Vitamin A: 10% Vitamin C: 100% Niacin (B3): 25% Pantothenic Acid (B5): 300% Vitamin B6: 300% Vitamin B12: 300% |
Essential Orange | Vitamin C: 250% Zinc: 25% Niacin (B3): 25% Pantothenic Acid (B5): – Vitamin B6: 20% Vitamin B12: – |
Energy Tropical Citrus | Niacin (B3): 100% Pantothenic Acid (B5): – Vitamin B6: – Vitamin B12: – |
Multi-V Lemonade | Vitamin A: 10% Vitamin C: 100% Calcium: – Magnesium: – Zinc: – |
Please note:
The sugar content of regular vitamin water negates any health benefits it may offer.
The Zero version may offer some potential benefits.
The vitamins and minerals in vitamin water may offer some nutritional benefits upon consumption.
Most of it might not be absorbed, but whatever remains could help.
People may be more inclined to consume vitamin water due to their attractive flavors.
While it does hydrate sufficiently, plain water is still the best way to hydrate.
Since vitamin water contains electrolytes like sodium and potassium, it may aid in post-workout recovery.
Vitamin water is sweetened with sucrose and fructose in the US.
Fructose is considered the most harmful component of added sugar.
The fructose content in vitamin water is nearly as much as that in normal Coca-Cola.
Weight loss diets are not just about staying away from high-calorie foods but also saying no to beverages filled with sugar.
Sugar-filled beverages do not even offer the benefits of solid food, like satiety or energy sources.
So they are even worse than sweet-rich foods.
Further, studies suggest that sugar-sweetened beverages are one of the leading causes of obesity.
Typically, excess vitamins and minerals are excreted via urine.
But if too much is consumed, it can become toxic to the body.
If vitamin water is your only source of vitamins, it might be safe.
You probably shouldn’t consume too much vitamin water along with a diet that contains vitamins.
The vitamins could accumulate and cause some harm to your body.
Expert Opinions
Research Findings
It is better to consume vitamin water occasionally rather than every day. Even the zero version may not suit everyone since the sugar alcohol in sweeteners can cause stomach disturbance in some.
Vitamin water can benefit stomach health through hydration and electrolyte replenishment. However, its high sugar content and potential for artificial additives may cause gastrointestinal discomfort in some individuals if consumed excessively. For optimal digestive health, plain water remains the best choice, and vitamin water can be consumed in moderation alongside a balanced diet rich in whole foods.
No solid evidence suggests that vitamin water is healthier than tap water. There are also not enough studies to investigate the potential benefits that vitamin water may offer.
The average recommended water intake is 3 liters. To replace water and compensate for hydration, one would need to drink ~5 bottles of Coca-Cola’s vitamin water. This can cause various problems:
Drinking vitamin water can lead to several side effects, primarily due to its high sugar content and potential for excessive vitamin intake.
Many varieties of vitamin water contain significant amounts of added sugars—often comparable to soft drinks—which can contribute to weight gain, obesity, type 2 diabetes, and other metabolic issues.
Additionally, consuming too many vitamins, particularly fat-soluble ones like A and E, can result in toxicity and adverse health effects.
Artificial sweeteners used in sugar-free versions may also cause gastrointestinal discomfort and cravings for more sugar.
Overall, while vitamin water can provide hydration and some nutrients, it should be consumed in moderation to avoid these potential side effects.
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https://www.healthline.com/nutrition/5-reasons-why-vitaminwater-is-a-bad-idea
https://cdnsciencepub.com/doi/10.1139/apnm-2014-0252
If you’ve ever wondered how people who eat healthy struggle to lose weight but people with the most unhealthy diets maintain a healthy weight, you’re in the right place. A complex interplay of several environmental and genetic factors determines your body weight. Environments may change, but your genetic makeup is unique to you. Getting a genetic test for weight loss is a great way to help you understand your health better, allowing you to make the right dietary choices.
For a long time, we’ve assumed that weight gain and loss depend almost entirely on our lifestyle.
Eat unhealthy foods and put on weight, eat healthier and watch the scale go down.
It may not be as simple as that anymore.
Now, researchers study the genetics of weight in greater detail.
A study surveyed the genetic background of patients who had undergone weight loss procedures.
The study revealed that genetics played a role in determining the procedure’s long-term effectiveness.
The authors also suggested that genetic screening of people with obesity can help recommend a personalized and cost-effective treatment option that would benefit the patient in the long term.
Suitable lifestyle modifications can help combat weight fluctuations.
Regular exercise and a refined diet have a significant impact on body weight.
In addition, habits like meditation to manage stress and a good sleep schedule can further help with weight loss.
Interestingly, how you respond to these healthy habits is influenced by your genes.
For example, dieting and a new sleep schedule work best for person A, while person B benefits more from regular exercise and meditation.
Your genetic makeup can determine which routine would impact your health more strongly.
Thus, getting a genetic test for weight loss is the best way to kickstart your wellness journey.
The short answer is yes.
However, no single “weight loss” gene directly controls the trait.
Your weight also indirectly depends on how you process food, adapt to exercise, handle stress, and more.
Your genetic makeup can answer all these questions:
Your genes aren’t entirely responsible for your body weight.
Factors from your environment and lifestyle contribute to weight gain, too.
Some of these non-genetic factors include:
Genetic testing for weight loss can help:
While lifestyle-related traits are easily noticeable, genetic traits aren’t immediately apparent.
For instance, you could trace a spike in weight back to a lack of exercise or a snacking spree in the recent past.
However, if you aren’t seeing enough results from your workout routine, you won’t be able to isolate the culprit genes.
That’s where genetic testing comes in.
Genetic testing can help you optimize your lifestyle, making your current diet and exercise routine more effective.
Healthy habits help, and genetic testing can augment them further.
Genetic testing for weight loss includes:
Ordering a DNA sample kit can cost up to a few hundred dollars.
Xcode Life offers a detailed, user-friendly genetic fitness test for just $30.
Some companies charge up to $200 for their weight loss-based panels.
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Common And Rare Side Effects Of Semaglutide For Weight Loss
https://www.healthline.com/nutrition/why-sitting-is-bad-for-you
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362746
https://www.webmd.com/sleep-disorders/features/lack-of-sleep-weight-gain
https://www.ncbi.nlm.nih.gov/books/NBK537590
https://www.medicalnewstoday.com/articles/depression-weight-gain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171810
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541372
Low calorific value, high antioxidant content, and healthy fats galore. What’s not to love about healthy oils like avocado and olive oil? Thanks to their innumerable health benefits, they’re all the rage now. But is one healthier than the other? To answer this question, let’s explore the similarities and differences between avocado and olive oil.
First things first, let’s take a look at their nutritional profiles:
Parameter | Avocado Oil | Olive Oil |
Calorific Value (kJ/kg) | 129 | 120 |
Fat Composition Saturated fat Monounsaturated fat Saturated fat | 14 g 2 g 10 g 2 g | 13.5 g 2 g 10 g 1.5 g |
Antioxidants (Vitamin E) | 23% of daily value (DV) | 33% of DV |
Here, we can see that:
Olive oil offers a host of health benefits, such as:
Olive oil is rich in mono-unsaturated fatty acids (MUFAs).
These fatty acids help increase the ‘good’ HDL cholesterol levels and decrease the ‘bad’ LDL cholesterol levels.
In fact, among all plant-based cooking oils, olive oil has the highest levels of MUFAs.
Olive oil is also anti-thrombotic, reducing the chances of a blood clot.
Its anti-atherogenic properties help clean up dangerous deposits in your blood vessels.
These properties are healthy for the heart and prevent heart disease.
Chronic inflammation encourages the onset of chronic and degenerative diseases.
Olive oil has a high polyphenol content, which helps reduce inflammatory molecules.
Olive oil combats chronic inflammation, reducing the risk of metabolic, cardiovascular, joint, and neurodegenerative diseases.
Polyphenols present in olive oil also have anti-cancer, anti-thrombotic, and anti-atherogenic properties.
For this reason, consumption of olive oil may help prevent some cancers.
Avocado oil is also rich in monounsaturated fats.
They enhance fat-soluble vitamin absorption (Vitamins A, D, E, and K).
Meals enriched with avocado oil help your body absorb vitamins effectively.
Avocado oil is highly moisturizing and is rich in vitamin E, a potent antioxidant.
Vitamin E supports skin health by reducing oxidative stress and hydrating skin.
It can also improve the skin’s elasticity and soothe irritated or dry skin.
When applied topically, avocado oil may:
Avocado oil is also rich in MUFAs, which are known to improve heart health.
Studies have found that avocado oil lowers bad LDL cholesterol and increases good HDL cholesterol levels.
They reduce inflammation and improve overall cardiovascular function.
Avocado oil also contains beta-sitosterol, a compound that further lowers cholesterol levels.
Thus, avocado oil supports cardiovascular health, too.
Smoke point is the temperature at which the fats in the oil begin to break down and turn into smoke.
Olive oil’s smoke point is around 374–405°F (190–207°C), making it a safe choice for cooking at home.
Avocado oil’s smoke point is around 500°F (260oC), making it a chef’s favorite and one of the most versatile cooking oils in larger kitchens.
Both olive and avocado oils can be used for cooking.
However, both oils have different taste profiles.
Olive oil has a smooth and versatile flavor profile– it is nutty, fresh, and peppery.
Avocado oil, on the other hand, is a more grassy, mildly sweet, and buttery flavor.
Between the two, olive oil is more suitable for nearly all foods.
Olive oil, particularly extra virgin olive oil (EVOO), is ideal for low- to medium-heat cooking, dressings, and drizzling.
It’s delicate and flavor-rich, perfect for uncooked dressing or gentle sautéing.
Due to its smoke point, it is better suited for lower-heat cooking and finishing dishes.
Avocado oil’s higher smoke point makes it perfect for high-heat cooking.
Its mild, neutral flavor makes it versatile for everything from frying to roasting.
With a smoke point of around 520°F (271°C), it is ideal for high-temperature techniques like frying, searing, and roasting.
Both oils have similar health benefits and are great for your health in the long run.
However, they have slightly varied nutritional value, and both oils have their spheres of use.
Olive oil is the more practical option at home.
It has the highest amount of MUFA among plant-based oils, making it a sought-after option for cooking.
Still, avocado oil has nearly the same health benefits and is considered one of the healthiest oils for cooking.
It could be a healthy option while eating out.
Avocado and olive oil are considered healthy fats and have many health benefits.
When choosing between the two, you can consider factors like flavor, price, and cooking methods.
Avocado oil is ideal for stir-frying due to its high smoke point.
Olive oil is more suitable for lighter cooking techniques like roasting.
Avocado oil can cause skin irritation on some skin types if consumed in excess.
It’s best to avoid avocado oil if you have any kind of vegetable oil allergy.
Mixing the oils results in a product with a unique aroma, better smoke point, and a balanced nutritional profile.
Have you ever wondered why some people seem more prone to urinary tract infections (UTIs) than others? While lifestyle factors and hygiene play a significant role, an intriguing question often arises: Are UTIs genetic? In this article, we’ll dive into the genetics of UTIs and explore whether your genes could contribute to your susceptibility.
UTIs are common infections that infect the urinary tract.
These infections are caused by bacteria that enter the urethra (the tube that expels urine from the bladder outside) either from the skin or the rectum.
The most common type of UTI is a bladder infection called cystitis. If unchecked, in rare cases, bladder infections can travel upwards to affect the kidney.
Around 60% of females and 12% of males will have experienced at least one episode of UTI during their lifetime.
You may have UTI if you experience one or more of the following symptoms:
If the UTI has spread to the kidneys, you may experience the following:
*Disclaimer: Please do not self-diagnose UTIs based only on the above information. Visit a qualified medical practitioner for the best course of action.
Yes, genetics is one of the factors that influence the development of UTIs. This risk is influenced predominantly by genes that regulate the immune responses of the host.
Recurrent Infections
According to research, 27% of females experience UTI recurrence within 6 months of the first infection, and 40% of kids who get a UTI develop another one within a year.
The recurrent nature of UTIs may indicate that this condition may have a genetic link with some females prone to them due to their family tree.
Family history
A few studies have reported that females who have recurrent UTIs have a stronger family history of UTIs compared to other females.
Genetic variants
Further research found that some people born with specific cell receptors in their urinary tracts that allow bacteria to stick to them better develop UTIs more often.
A 2010 study on UTIs found that 6 out of 14 genes investigated may be associated with genetic susceptibility to recurrent UTIs in humans.
These studies show that being prone to UTIs may have to do with your genetic makeup and heredity.
The genes implicated control the immune system pathways in the body. Any variations in these genes have also been found to increase your UTI risk.
There is no clear inheritance pattern for UTIs. When there’s an affected family member, female relatives of that member tend to have a higher risk.
Though UTIs are not contagious, the bacteria causing this infection can travel from one person to another.
Research states that having a mother or sister with recurrent UTIs increases your risk of developing the condition more often.
This has to do with your genes.
Some females inherit cell receptors in the urinary tract from their biological mothers, which allows bacteria to stick better, causing recurrent UTIs.
Bacteria live in large numbers around the vagina and the rectum.
When these bacteria enter the urinary tract due to wrong personal hygiene practices, they tend to cause UTIs.
Just like some people are prone to colds and allergies, many are prone to UTIs.
A few factors known to cause and increase the risk of UTIs include:
Genetics does not directly cause UTIs. However, when combined with environmental and lifestyle factors, your genes can influence your risk for UTIs.
Several personal hygiene practices can increase your risk for UTIs. For example:
Sexual intercourse and other associated practices can increase the risk for UTIs.
Public hot tubs and jacuzzis are the perfect breeding ground for bacteria that cause UTIs.
Working in an unclean environment has been found to cause an increased incidence of UTIs.
Whether you are prone to UTIs or just wish to stay clear of these pesky infections, here are a few ways to prevent them:
Keeping yourself hydrated and drinking adequate water helps flush out bacteria in the urinary tract every time you urinate.
Though UTIs are nagging infections, they are easy to manage.
Treatment and management of UTIs depend upon the severity of the infection, your symptoms, and the causative organism (that can be detected using a urinary culture).
Antibiotics are usually the first line of treatment for UTIs.
Following healthy personal hygiene practices and staying hydrated can also help alleviate the symptoms and reduce the recurrence of UTIs.
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