What HLA-DQ genes confer the most risk for Celiac Disease (CD)?

The presence of the HLA-DQ2 and HLA-DQ8 subtypes confer the highest risk for CD. HLA-DQ2 (~95%) OR HLA-DQ8 (~5%) are present in almost all people with CD. A CD diagnosis after testing negative for both these subtypes is highly unlikely.

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What HLA-DQ genes confer the most risk for Celiac Disease (CD)?

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