Gene: ABHD8

Alternate names for this Gene: -

Gene Summary: This gene is upstream of, and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34. The predicted protein contains alpha/beta hydrolase fold and secretory lipase domains.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.11

Description of this Gene: abhydrolase domain containing 8

Type of Gene: protein-coding

Gene: MRPL34

Alternate names for this Gene: L34mt

Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.11

Description of this Gene: mitochondrial ribosomal protein L34

Type of Gene: protein-coding

rs12982058 in ABHD8;MRPL34 gene and Malignant neoplasm of breast PMID 20852631 2010 A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.