Gene: ACKR2

Alternate names for this Gene: CCBP2|CCR10|CCR9|CMKBR9|D6|hD6

Gene Summary: This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

Gene is located in Chromosome: 3

Location in Chromosome : 3p22.1

Description of this Gene: atypical chemokine receptor 2

Type of Gene: protein-coding

Gene: KRBOX1

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: CYP8B1

Alternate names for this Gene: CP8B|CYP12

Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless.

Gene is located in Chromosome: 3

Location in Chromosome : 3p22.1

Description of this Gene: cytochrome P450 family 8 subfamily B member 1

Type of Gene: protein-coding

rs3919627 in ACKR2;KRBOX1;CYP8B1 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs2228468 in ACKR2;KRBOX1;CYP8B1 gene and Monocyte count procedure PMID 28158719 2017 Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.

PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 23314186 2013 Genetic variation associated with circulating monocyte count in the eMERGE Network.

rs2228468 in ACKR2;KRBOX1;CYP8B1 gene and Monocyte count result PMID 28158719 2017 Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.

PMID 23314186 2013 Genetic variation associated with circulating monocyte count in the eMERGE Network.

PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs2228468 in ACKR2;KRBOX1;CYP8B1 gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.