Gene: ACVR2B

Alternate names for this Gene: ACTRIIB|ActR-IIB|HTX4

Gene Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Gene is located in Chromosome: 3

Location in Chromosome : 3p22.2

Description of this Gene: activin A receptor type 2B

Type of Gene: protein-coding

Gene: ACVR2B-AS1

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 3

Location in Chromosome : 3p22.2

Description of this Gene: ACVR2B antisense RNA 1

Type of Gene: ncRNA