Gene: ADAM12

Alternate names for this Gene: ADAM12-OT1|CAR10|MCMP|MCMPMltna|MLTN|MLTNA

Gene Summary: This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form.

Gene is located in Chromosome: 10

Location in Chromosome : 10q26.2

Description of this Gene: ADAM metallopeptidase domain 12

Type of Gene: protein-coding

rs1278352 in ADAM12 gene and Attention deficit hyperactivity disorder PMID 26184070 2016 Gene-set and multivariate genome-wide association analysis of oppositional defiant behavior subtypes in attention-deficit/hyperactivity disorder.

PMID 27021288 2016 Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder.

rs10794057 in ADAM12 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs1278259 in ADAM12 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs7084390 in ADAM12 gene and Corpuscular Hemoglobin Concentration Mean PMID 23222517 2012 Seventy-five genetic loci influencing the human red blood cell.

rs1676712 in ADAM12 gene and Influenza due to Influenza A virus subtype H1N1 PMID 26379185 2015 No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.

rs4962322 in ADAM12 gene and Intelligence PMID 29731509 2018 A genome-wide association study for extremely high intelligence.

rs35025137 in ADAM12 gene and Serum total cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs10901553 in ADAM12 gene and Tonometry PMID 30054594 2018 Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.