Gene: ADCY3
Alternate names for this Gene: AC-III|AC3|BMIQ19
Gene Summary: This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 2
Location in Chromosome : 2p23.3
Description of this Gene: adenylate cyclase 3
Type of Gene: protein-coding
rs11125803 in
ADCY3 gene and
Age at menarche
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs13407913 in
ADCY3 gene and
Ankylosing spondylitis
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
rs10203386 in
ADCY3 gene and
Body mass index
PMID 31453325 2019 Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.
PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
PMID 28430825 2017 Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.
PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.
PMID 29273807 2018 Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
PMID 26604143 2016 Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
PMID 25953783 2015 A genome-wide association study of body mass index across early life and childhood.
PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.
PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
PMID 23583978 2013 A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
rs11676272 in
ADCY3 gene and
Body mass index procedure
PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.
PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
PMID 23583978 2013 A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
rs6725517 in
ADCY3 gene and
Breast Carcinoma
PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.
rs13407913 in
ADCY3 gene and
Cholangitis, Sclerosing
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
rs13407913 in
ADCY3 gene and
Crohn Disease
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
PMID 28067908 2017 Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
rs11676272 in
ADCY3 gene and
Dental caries
PMID 31235808 2019 Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.
rs10198275 in
ADCY3 gene and
Diastolic blood pressure
PMID 27841878 2017 Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
PMID 28135244 2017 Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
rs11676272 in
ADCY3 gene and
Finding of body mass index
PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.
PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
PMID 23583978 2013 A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
rs10200566 in
ADCY3 gene and
Hip circumference
PMID 31453325 2019 Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.
PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.
rs13407913 in
ADCY3 gene and
Inflammatory Bowel Diseases
PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
PMID 28067908 2017 Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
PMID 23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
rs13407913 in
ADCY3 gene and
Psoriasis
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
rs10206196 in
ADCY3 gene and
Reticulocyte count (procedure)
PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
rs56073414 in
ADCY3 gene and
Systolic Pressure
PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
rs13407913 in
ADCY3 gene and
Ulcerative Colitis
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.