Gene: ADCY4

Alternate names for this Gene: AC4

Gene Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants.

Gene is located in Chromosome: 14

Location in Chromosome : 14q12

Description of this Gene: adenylate cyclase 4

Type of Gene: protein-coding

rs3181382 in ADCY4 gene and Necrotizing Enterocolitis PMID 29538362 2018 Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8.

rs3181382 in ADCY4 gene and Necrotizing enterocolitis in fetus OR newborn PMID 29538362 2018 Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8.

rs3181382 in ADCY4 gene and Premature Birth PMID 29538362 2018 Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8.

rs74385226 in ADCY4 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.