Gene: ADCY9

Alternate names for this Gene: AC9|ACIX

Gene Summary: Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.

Gene is located in Chromosome: 16

Location in Chromosome : 16p13.3

Description of this Gene: adenylate cyclase 9

Type of Gene: protein-coding

rs1967309 in ADCY9 gene and Acute Coronary Syndrome PMID 25583994 2015 Pharmacogenomic determinants of the cardiovascular effects of dalcetrapib.

rs2907272 in ADCY9 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.

rs2531995 in ADCY9 gene and Body Weight PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

rs2238435 in ADCY9 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

PMID 28892062 2017 Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

rs2444217 in ADCY9 gene and Body mass index procedure PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

rs2531992 in ADCY9 gene and Bone Density PMID 30690781 2019 Joint Association Analysis Identified 18 New Loci for Bone Mineral Density.

rs11076805 in ADCY9 gene and Breast Carcinoma PMID 29058716 2017 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs11647570 in ADCY9 gene and Cardiovascular Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2601828 in ADCY9 gene and Epilepsies, Partial PMID 20522523 2010 Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.

rs2444217 in ADCY9 gene and Finding of body mass index PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

rs879620 in ADCY9 gene and Hip circumference PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.

rs2531995 in ADCY9 gene and Lean body mass PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

rs12598529 in ADCY9 gene and Lymphocyte Count measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs2531995 in ADCY9 gene and Obesity PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

rs2531995 in ADCY9 gene and Physical Activity Measurement PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

rs7185966 in ADCY9 gene and RDW - Red blood cell distribution width result PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs7185966 in ADCY9 gene and Red cell distribution width determination PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1034906 in ADCY9 gene and Systolic Pressure PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1045476 in ADCY9 gene and Thyroid stimulating hormone measurement PMID 30367059 2018 Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

rs2531992 in ADCY9 gene and Waist Circumference PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.

rs879620 in ADCY9 gene and body fat percentage (physical finding) PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.