Gene: ADGRD1

Alternate names for this Gene: GPR133|PGR25

Gene Summary: The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010].

Gene is located in Chromosome: 12

Location in Chromosome : 12q24.33

Description of this Gene: adhesion G protein-coupled receptor D1

Type of Gene: protein-coding

rs11061269 in ADGRD1 gene and AMYOTROPHIC LATERAL SCLEROSIS 1 PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs11061269 in ADGRD1 gene and AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs11061269 in ADGRD1 gene and AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs11061269 in ADGRD1 gene and Amyotrophic Lateral Sclerosis, Sporadic PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs1569019 in ADGRD1 gene and Body Height PMID 19729412 2009 Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1569019 in ADGRD1 gene and Height PMID 19729412 2009 Upon replication, the SNP rs1569019 showed significant effects on height in the Leipzig cohort (P = 0.004, beta = 1.166) and in 577 men of the Berlin cohort (P = 0.049, beta = 1.127) though not in women.

PMID 19729412 2009 In the meta-analysis on those 455 SNPs, only two variants in GPR133 (rs1569019 and rs1976930; in LD with each other) retained a P-value at or below 10(-6) and were associated with height in the three cohorts individually.

rs3847687 in ADGRD1 gene and Longevity PMID 20834067 2010 Joint influence of small-effect genetic variants on human longevity.