Gene: ADGRG6
Alternate names for this Gene: APG1|DREG|GPR126|LCCS9|PR126|PS1TP2|VIGR
Gene Summary: This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene.
Gene is located in Chromosome: 6
Location in Chromosome : 6q24.2
Description of this Gene: adhesion G protein-coupled receptor G6
Type of Gene: protein-coding
rs6570507 in
ADGRG6 gene and
Adolescent idiopathic scoliosis
PMID 30395268 2018 Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.
PMID 24023777 2013 Identification of a susceptibility locus for severe adolescent idiopathic scoliosis on chromosome 17q24.3.
PMID 31417091 2019 Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.
rs962554 in
ADGRG6 gene and
Birth Weight
PMID 31043758 2019 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
rs9399401 in
ADGRG6 gene and
Blood Pressure
PMID 30940143 2019 Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis.
rs6570507 in
ADGRG6 gene and
Body Fat Distribution
PMID 30664634 2019 Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.
rs3748069 in
ADGRG6 gene and
Body Height
PMID 18391951 2008 Many sequence variants affecting diversity of adult human height.
PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.
PMID 25282103 2014 Defining the role of common variation in the genomic and biological architecture of adult human height.
PMID 18391950 2008 Identification of ten loci associated with height highlights new biological pathways in human growth.
PMID 19343178 2009 Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
PMID 20397748 2010 Genome-wide association study of height and body mass index in Australian twin families.
PMID 25429064 2015 Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
PMID 28270201 2017 Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.
rs6922607 in
ADGRG6 gene and
Body mass index
PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs9399401 in
ADGRG6 gene and
Chronic Obstructive Airway Disease
PMID 28166215 2017 Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
PMID 30804561 2019 Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
PMID 30940143 2019 Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis.
rs3817928 in
ADGRG6 gene and
Forced expiratory volume function
PMID 23284291 2012 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
PMID 28166213 2017 Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
rs3748069 in
ADGRG6 gene and
Height
PMID 18391951 2008 Many sequence variants affecting diversity of adult human height.
PMID 18391950 2008 Identification of ten loci associated with height highlights new biological pathways in human growth.
PMID 19343178 2009 Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
PMID 20397748 2010 Genome-wide association study of height and body mass index in Australian twin families.
PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
rs6570509 in
ADGRG6 gene and
Lean body mass
PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.
rs4896582 in
ADGRG6 gene and
Physical Activity Measurement
PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
rs1040525 in
ADGRG6 gene and
Pulmonary function
PMID 20010835 2010 Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
rs1040525 in
ADGRG6 gene and
Pulmonary function (finding)
PMID 20010835 2010 Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
rs3817928 in
ADGRG6 gene and
Respiratory Function Tests
PMID 20010835 2010 Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
PMID 23284291 2012 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
rs6570507 in
ADGRG6 gene and
SCOLIOSIS, IDIOPATHIC, SUSCEPTIBILITY TO, 1 (finding)
PMID 24023777 2013 Identification of a susceptibility locus for severe adolescent idiopathic scoliosis on chromosome 17q24.3.
rs6570507 in
ADGRG6 gene and
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
PMID 30395268 2018 Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.
PMID 31417091 2019 Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.
rs6570507 in
ADGRG6 gene and
Scoliosis, unspecified
PMID 23666238 2013 Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.
rs6570507 in
ADGRG6 gene and
Smoking
PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
rs6570507 in
ADGRG6 gene and
Smoking Behaviors
PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
rs17280293 in
ADGRG6 gene and
Vital capacity
PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
rs17280293 in
ADGRG6 gene and
peak expiratory flow (procedure)
PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.