Gene: ADH7

Alternate names for this Gene: ADH4

Gene Summary: This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 4

Location in Chromosome : 4q23

Description of this Gene: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Type of Gene: protein-coding

rs17529509 in ADH7 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs971074 in ADH7 gene and Head and Neck Neoplasms PMID 21437268 2011 A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.