Gene: AGAP1

Alternate names for this Gene: AGAP-1|CENTG2|GGAP1|cnt-g2

Gene Summary: This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 2

Location in Chromosome : 2q37.2

Description of this Gene: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

Type of Gene: protein-coding

rs11676226 in AGAP1 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10208807 in AGAP1 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs3768939 in AGAP1 gene and Cardiovascular Diseases PMID 26516778 2015 Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium.

rs3754648 in AGAP1 gene and Goldenhar Syndrome PMID 26853712 2016 Genome-wide association study identifies multiple susceptibility loci for craniofacial microsomia.

rs3768939 in AGAP1 gene and Hypertensive disease PMID 26516778 2015 Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium.

rs10190094 in AGAP1 gene and Osteoarthritis, Knee PMID 29559693 2018 Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.

rs10929159 in AGAP1 gene and Parkinson Disease PMID 28892059 2017 A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.

rs13025591 in AGAP1 gene and Schizophrenia PMID 22688191 2012 Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.

PMID 19571809 2009 Common variants on chromosome 6p22.1 are associated with schizophrenia.

rs55823170 in AGAP1 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs12471554 in AGAP1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.