Gene: AGPAT1

Alternate names for this Gene: 1-AGPAT1|G15|LPAAT-alpha|LPAATA

Gene Summary: This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: 1-acylglycerol-3-phosphate O-acyltransferase 1

Type of Gene: protein-coding

Gene: RNF5

Alternate names for this Gene: RING5|RMA1

Gene Summary: The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: ring finger protein 5

Type of Gene: protein-coding

rs3134947 in AGPAT1;RNF5 gene and Rheumatoid Arthritis PMID 21156761 2011 A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

rs3134947 in AGPAT1;RNF5 gene and Vitiligo PMID 20526339 2010 Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.