Gene: AGPAT1

Alternate names for this Gene: 1-AGPAT1|G15|LPAAT-alpha|LPAATA

Gene Summary: This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: 1-acylglycerol-3-phosphate O-acyltransferase 1

Type of Gene: protein-coding

rs408359 in AGPAT1 gene and Diabetes Mellitus, Insulin-Dependent PMID 17632545 2007 A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

rs3130284 in AGPAT1 gene and Rheumatoid Arthritis PMID 21156761 2011 A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

rs3130284 in AGPAT1 gene and Vitiligo PMID 20526339 2010 Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.