Gene: AIP

Alternate names for this Gene: ARA9|FKBP16|FKBP37|PITA1|SMTPHN|XAP-2|XAP2

Gene Summary: The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11q13.2

Description of this Gene: aryl hydrocarbon receptor interacting protein

Type of Gene: protein-coding

rs12795957 in AIP gene and Body Height PMID 29782485 2018 Evaluation and application of summary statistic imputation to discover new height-associated loci.

rs104894190 in AIP gene and PITUITARY ADENOMA 1, MULTIPLE TYPES PMID 16728643 2006 Pituitary adenoma predisposition caused by germline mutations in the AIP gene.

PMID 30461320 2018 Screening of AIP Gene Variations in a Cohort of Turkish Patients with Young-Onset Sporadic Hormone-Secreting Pituitary Adenomas.

PMID 17244780 2007 Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families.

PMID 18410548 2008 Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children and adolescents with sporadic pituitary adenomas.

PMID 17299063 2007 Mutations in the aryl hydrocarbon receptor interacting protein gene are not highly prevalent among subjects with sporadic pituitary adenomas.

PMID 17341560 2007 Germline mutation in the aryl hydrocarbon receptor interacting protein gene in familial somatotropinoma.

PMID 17360484 2007 Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations.

rs11227805 in AIP gene and Uric acid measurement (procedure) PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.