Gene: AKR1C4

Alternate names for this Gene: 3-alpha-HSD|C11|CDR|CHDR|DD-4|DD4|HAKRA

Gene Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Gene is located in Chromosome: 10

Location in Chromosome : 10p15.1

Description of this Gene: aldo-keto reductase family 1 member C4

Type of Gene: protein-coding

rs1832007 in AKR1C4 gene and Triglycerides measurement PMID 24097068 2013 Discovery and refinement of loci associated with lipid levels.

PMID 28334899 2017 Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.