Gene: AKR1C4
Alternate names for this Gene: 3-alpha-HSD|C11|CDR|CHDR|DD-4|DD4|HAKRA
Gene Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Gene is located in Chromosome: 10
Location in Chromosome : 10p15.1
Description of this Gene: aldo-keto reductase family 1 member C4
Type of Gene: protein-coding