Gene: AKR7A3

Alternate names for this Gene: AFAR2

Gene Summary: Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]. ##Evidence-Data-START## Transcript exon combination :: AF040639.1, BC025709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152474 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361640.5/ ENSP00000355377.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.13

Description of this Gene: aldo-keto reductase family 7 member A3

Type of Gene: protein-coding

Gene: AKR7L

Alternate names for this Gene: AFAR3|AFB1-AR 3|AFB1-AR3|AKR7A4

Gene Summary: This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.13|1p35-p36.1

Description of this Gene: aldo-keto reductase family 7 like (gene/pseudogene)

Type of Gene: protein-coding