Gene: ALDH1L1

Alternate names for this Gene: 10-FTHFDH|10-fTHF|FDH|FTHFD

Gene Summary: The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 3

Location in Chromosome : 3q21.3

Description of this Gene: aldehyde dehydrogenase 1 family member L1

Type of Gene: protein-coding

Gene: ALDH1L1-AS2

Alternate names for this Gene:

Gene Summary:

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rs750714 in ALDH1L1;ALDH1L1-AS2 gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10934754 in ALDH1L1;ALDH1L1-AS2 gene and Glomerular Filtration Rate PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

PMID 31451708 2019 Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program.

rs2364368 in ALDH1L1;ALDH1L1-AS2 gene and Glycine measurement PMID 31070104 2019 Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease.

PMID 30837465 2019 Assessing the causal association of glycine with risk of cardio-metabolic diseases.