Gene: ALLC

Alternate names for this Gene: ALC

Gene Summary: Allantoicase (EC 3.5.3.4) participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution.[supplied by OMIM, Nov 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.188641.1, AK302299.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252505.4/ ENSP00000252505.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

Gene is located in Chromosome: 2

Location in Chromosome : 2p25.3

Description of this Gene: allantoicase

Type of Gene: protein-coding

rs11123610 in ALLC gene and Asthma PMID 24792382 2014 Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.

rs1594318 in ALLC gene and Dental caries PMID 29931343 2018 Evidence for association with caries status was observed at rs1594318-C for primary teeth [intronic within ALLC, odds ratio (OR) 0.85, effect allele frequency (EAF) 0.60, P 4.13e-8] and rs7738851-A (intronic within NEDD9, OR 1.28, EAF 0.85, P 1.63e-8) for permanent teeth.