Gene: ALPK1

Alternate names for this Gene: 8430410J10Rik|LAK|ROSAH

Gene Summary: This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 4

Location in Chromosome : 4q25

Description of this Gene: alpha kinase 1

Type of Gene: protein-coding

Gene: TIFA

Alternate names for this Gene: T2BP|T6BP|TIFAA

Gene Summary: This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response.

Gene is located in Chromosome: 4

Location in Chromosome : 4q25

Description of this Gene: TRAF interacting protein with forkhead associated domain

Type of Gene: protein-coding