Gene: AMFR

Alternate names for this Gene: GP78|RNF45

Gene Summary: This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins.

Gene is located in Chromosome: 16

Location in Chromosome : 16q13

Description of this Gene: autocrine motility factor receptor

Type of Gene: protein-coding

rs2432539 in AMFR gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.