Gene: AMN
Alternate names for this Gene: IGS2|PRO1028|amnionless
Gene Summary: The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.
Gene is located in Chromosome: 14
Location in Chromosome : 14q32.32
Description of this Gene: amnion associated transmembrane protein
Type of Gene: protein-coding
rs1555381485 in
AMN gene and
Megaloblastic Anemia 1
PMID 22929189 2012 Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns.
PMID 12590260 2003 Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia.
PMID 30523278 2018 Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption.
PMID 26040326 2015 Novel compound heterozygous mutations in AMN cause Imerslund-Gräsbeck syndrome in two half-sisters: a case report.
PMID 29402915 2018 Amnionless-mediated glycosylation is crucial for cell surface targeting of cubilin in renal and intestinal cells.
PMID 22631584 2012 Imerslund-Gräsbeck syndrome: new mutation in amnionless.