Gene: ANKRD17

Alternate names for this Gene: GTAR|MASK2|NY-BR-16

Gene Summary: The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene is located in Chromosome: 4

Location in Chromosome : 4q13.3

Description of this Gene: ankyrin repeat domain 17

Type of Gene: protein-coding

rs6818964 in ANKRD17 gene and Dental caries of smooth surface PMID 24556642 2014 Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.

rs187918276 in ANKRD17 gene and Low density lipoprotein cholesterol measurement PMID 29084231 2017 Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.

rs187918276 in ANKRD17 gene and Serum total cholesterol measurement PMID 29084231 2017 Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.