Gene: ANO10

Alternate names for this Gene: SCAR10|TMEM16K

Gene Summary: The transmembrane protein encoded by this gene belongs to the anoctamin family of calcium-activated chloride channels, also known as the transmembrane 16 family. The encoded protein contains eight transmembrane domains with cytosolic N- and C-termini. Defects in this gene may cause autosomal recessive spinocerebellar ataxia-10. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 3

Location in Chromosome : 3p22.1-p21.33

Description of this Gene: anoctamin 10

Type of Gene: protein-coding

rs41289586 in ANO10 gene and Non-Hodgkin's lymphoma of central nervous system PMID 31102405 2019 A genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC network study.

rs7650267 in ANO10 gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs387907089 in ANO10 gene and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 10 PMID 21092923 2010 Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia.