Gene: AOPEP

Alternate names for this Gene: AP-O|APO|C90RF3|C9orf3|ONPEP

Gene Summary: This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants.

Gene is located in Chromosome: 9

Location in Chromosome : 9q22.32

Description of this Gene: aminopeptidase O (putative)

Type of Gene: protein-coding

rs10761362 in AOPEP gene and Adiponectin Measurement PMID 20887962 2010 Adiponectin concentrations: a genome-wide association study.

rs10821415 in AOPEP gene and Atrial Fibrillation PMID 22544366 2012 Meta-analysis identifies six new susceptibility loci for atrial fibrillation.

PMID 30061737 2018 Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.

PMID 29892015 2018 Multi-ethnic genome-wide association study for atrial fibrillation.

PMID 28416818 2017 Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

rs10993370 in AOPEP gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10993397 in AOPEP gene and Polycystic Ovary Syndrome PMID 26284813 2015 Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

PMID 22885925 2012 Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.

PMID 30566500 2018 Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.