Gene: AP1S1

Alternate names for this Gene: AP19|CLAPS1|EKV3|MEDNIK|SIGMA1A

Gene Summary: The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle.

Gene is located in Chromosome: 7

Location in Chromosome : 7q22.1

Description of this Gene: adaptor related protein complex 1 subunit sigma 1

Type of Gene: protein-coding

rs1048303 in AP1S1 gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.