Gene: APAF1

Alternate names for this Gene: APAF-1|CED4

Gene Summary: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Gene is located in Chromosome: 12

Location in Chromosome : 12q23.1

Description of this Gene: apoptotic peptidase activating factor 1

Type of Gene: protein-coding