Gene: ARAP3

Alternate names for this Gene: CENTD3|DRAG1

Gene Summary: This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined.

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.3

Description of this Gene: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

Type of Gene: protein-coding

rs11957761 in ARAP3 gene and Birth Weight PMID 31043758 2019 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

rs3749759 in ARAP3 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs79464052 in ARAP3 gene and Diffuse Large B-Cell Lymphoma PMID 25261932 2014 Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.