Gene: ARHGAP1

Alternate names for this Gene: CDC42GAP|RHOGAP|RHOGAP1|p50rhoGAP

Gene Summary: This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members.

Gene is located in Chromosome: 11

Location in Chromosome : 11p11.2

Description of this Gene: Rho GTPase activating protein 1

Type of Gene: protein-coding

Gene: ZNF408

Alternate names for this Gene: EVR6|RP72

Gene Summary: The protein encoded by this gene contains ten tandem zinc fingers and an N-terminal SET domain, so it is likely a DNA binding protein that interacts with other proteins. In adults, the encoded protein is expressed most highly in retina. Consequently, defects in this gene have been associated with familial exudative vitreoretinopathy (FEVR) and retinitis pigmentosa (RP).

Gene is located in Chromosome: 11

Location in Chromosome : 11p11.2

Description of this Gene: zinc finger protein 408

Type of Gene: protein-coding

rs7932354 in ARHGAP1;ZNF408 gene and Bone Density PMID 19801982 2009 Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.

rs7932354 in ARHGAP1;ZNF408 gene and Bone Mineral Density Test PMID 22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.