Gene: ARHGAP26
Alternate names for this Gene: GRAF|GRAF1|OPHN1L|OPHN1L1
Gene Summary: Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 5
Location in Chromosome : 5q31.3
Description of this Gene: Rho GTPase activating protein 26
Type of Gene: protein-coding