Gene: ARHGAP29

Alternate names for this Gene: PARG1

Gene Summary: Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate.

Gene is located in Chromosome: 1

Location in Chromosome : 1p22.1

Description of this Gene: Rho GTPase activating protein 29

Type of Gene: protein-coding

rs1411701 in ARHGAP29 gene and Cleft upper lip PMID 22863734 2012 Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.

rs2274788 in ARHGAP29 gene and Triglycerides measurement PMID 23400010 2014 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.