Gene: ARHGEF25

Alternate names for this Gene: GEFT|p63RhoGEF

Gene Summary: Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.3

Description of this Gene: Rho guanine nucleotide exchange factor 25

Type of Gene: protein-coding

Gene: DTX3

Alternate names for this Gene: RNF154|deltex3

Gene Summary: DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009].

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.3

Description of this Gene: deltex E3 ubiquitin ligase 3

Type of Gene: protein-coding