Gene: ARHGEF26-AS1
Alternate names for this Gene:
Gene Summary:
Gene is located in Chromosome:
Location in Chromosome :
Description of this Gene:
Type of Gene:
Gene: ARHGEF26
Alternate names for this Gene: CSGEF|HMFN1864|SGEF
Gene Summary: This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene is located in Chromosome: 3
Location in Chromosome : 3q25.2
Description of this Gene: Rho guanine nucleotide exchange factor 26
Type of Gene: protein-coding
rs12493885 in
ARHGEF26-AS1;ARHGEF26 gene and
Coronary Artery Disease
PMID 28714975 2017 Association analyses based on false discovery rate implicate new loci for coronary artery disease.
PMID 29212778 2018 Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
PMID 28714974 2017 Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.