Gene: ARHGEF40

Alternate names for this Gene: SOLO

Gene Summary: This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain. Alternatively spliced transcripts that encode different proteins have been described.

Gene is located in Chromosome: 14

Location in Chromosome : 14q11.2

Description of this Gene: Rho guanine nucleotide exchange factor 40

Type of Gene: protein-coding

rs12889267 in ARHGEF40 gene and Hematocrit procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs12889267 in ARHGEF40 gene and Lean body mass PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

rs12889267 in ARHGEF40 gene and RESTING HEART RATE PMID 27798624 2016 Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.

rs12889267 in ARHGEF40 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.