Gene: ARHGEF6

Alternate names for this Gene: COOL2|Cool-2|MRX46|PIXA|alpha-PIX|alphaPIX

Gene Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability.

Gene is located in Chromosome: X

Location in Chromosome : Xq26.3

Description of this Gene: Rac/Cdc42 guanine nucleotide exchange factor 6

Type of Gene: protein-coding