Gene: ARID2

Alternate names for this Gene: BAF200|CSS6|p200

Gene Summary: This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1.

Gene is located in Chromosome: 12

Location in Chromosome : 12q12

Description of this Gene: AT-rich interaction domain 2

Type of Gene: protein-coding

rs772995852 in ARID2 gene and COFFIN-SIRIS SYNDROME 6 PMID 26238514 2015 Mutations in ARID2 are associated with intellectual disabilities.

rs1650007 in ARID2 gene and Intelligence PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.

rs1863127 in ARID2 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs7316454 in ARID2 gene and Triglycerides measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.