Gene: ARMS2

Alternate names for this Gene: ARMD8

Gene Summary: This gene encodes a small secreted protein specific to primates. This protein is a component of the choroidal extracellular matrix of the eye. Mutations in this gene are associated with age-related macular degeneration.

Gene is located in Chromosome: 10

Location in Chromosome : 10q26.13

Description of this Gene: age-related maculopathy susceptibility 2

Type of Gene: protein-coding

Gene: LOC105378525

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

rs10490924 in ARMS2;LOC105378525 gene and Age related macular degeneration PMID 22705344 2012 Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

PMID 22694956 2012 Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.

PMID 23577725 2013 Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.

PMID 23455636 2013 Seven new loci associated with age-related macular degeneration.

PMID 21665990 2011 Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.

PMID 21909106 2011 Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.

PMID 28703135 2017 We confirmed the association of age-related maculopathy susceptibility 2 (ARMS2) rs10490924 (P=7.38 × 10<sup>-17</sup>), HTRA1 rs11200638 (P=5.47 × 10<sup>-17</sup>) and complement factor H gene (CFH) rs800292 (P=2.53 × 10<sup>-8</sup>) with neovascular AMD, all loci passing the genome-wide significance level (P<5.22 × 10<sup>-8</sup>).

PMID 20385826 2010 Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

PMID 20861866 2010 Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.

PMID 23326517 2013 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.

PMID 17053108 2006 HTRA1 promoter polymorphism in wet age-related macular degeneration.

PMID 26691988 2016 A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

rs10490924 in ARMS2;LOC105378525 gene and Exudative age-related macular degeneration PMID 28703135 2017 Genome-wide association study of neovascular age-related macular degeneration in the Thai population.

PMID 25629512 2015 New loci and coding variants confer risk for age-related macular degeneration in East Asians.

PMID 22705344 2012 Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

PMID 26691988 2016 A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

rs10490924 in ARMS2;LOC105378525 gene and Geographic Atrophy PMID 22705344 2012 In the analysis comparing participants with CNV to those with GA, a statistically significant association was observed at the ARMS2/HTRA1 locus (rs10490924; odds ratio [OR], 1.47; P = 4.3 × 10(-9)), which was confirmed in the replication samples (OR, 1.38; P = 7.4 × 10(-14) for combined discovery and replication analysis).

PMID 26691988 2016 A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

rs10490924 in ARMS2;LOC105378525 gene and exudative macular degeneration PMID 28703135 2017 Genome-wide association study of neovascular age-related macular degeneration in the Thai population.

PMID 22705344 2012 Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

PMID 25629512 2015 New loci and coding variants confer risk for age-related macular degeneration in East Asians.

PMID 26691988 2016 A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.