Gene: ARPC1A

Alternate names for this Gene: Arc40|HEL-68|HEL-S-307|SOP2Hs|SOP2L

Gene Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 7

Location in Chromosome : 7q22.1

Description of this Gene: actin related protein 2/3 complex subunit 1A

Type of Gene: protein-coding

rs147642358 in ARPC1A gene and Acute Coronary Syndrome PMID 25935875 2015 Effect of genetic variations on ticagrelor plasma levels and clinical outcomes.

rs740160 in ARPC1A gene and Hormone measurement PMID 21533175 2011 Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

rs2301889 in ARPC1A gene and RDW - Red blood cell distribution width result PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2301889 in ARPC1A gene and Red cell distribution width determination PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.