Gene: ASAH2B

Alternate names for this Gene: ASAH2C|ASAH2L|bA449O16.3|bA98I6.3

Gene Summary:

Gene is located in Chromosome: 10

Location in Chromosome : 10q11.23

Description of this Gene: N-acylsphingosine amidohydrolase 2B

Type of Gene: protein-coding

Gene: A1CF

Alternate names for this Gene: ACF|ACF64|ACF65|APOBEC1CF|ASP

Gene Summary: Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene is located in Chromosome: 10

Location in Chromosome : 10q11.23

Description of this Gene: APOBEC1 complementation factor

Type of Gene: protein-coding

rs41274050 in ASAH2B;A1CF gene and Alcohol consumption PMID 30698716 2019 Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

rs41274050 in ASAH2B;A1CF gene and Low density lipoprotein cholesterol measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs41274050 in ASAH2B;A1CF gene and Serum total cholesterol measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs41274050 in ASAH2B;A1CF gene and Triglycerides measurement PMID 29083408 2017 Exome-wide association study of plasma lipids in >300,000 individuals.

PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

PMID 30698716 2019 Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

rs4256922 in ASAH2B;A1CF gene and Uric acid measurement (procedure) PMID 25811787 2015 Modulation of genetic associations with serum urate levels by body-mass-index in humans.