Gene: BACE1

Alternate names for this Gene: ASP2|BACE|HSPC104

Gene Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.

Gene is located in Chromosome: 11

Location in Chromosome : 11q23.3

Description of this Gene: beta-secretase 1

Type of Gene: protein-coding

Gene: RNF214

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 11

Location in Chromosome : 11q23.3

Description of this Gene: ring finger protein 214

Type of Gene: protein-coding

rs1047964 in BACE1;RNF214 gene and Cardiovascular Diseases PMID 21779381 2011 Further, rs1047964 in BACE1 appeared to be associated with CVD death among women with any migraine (OR = 4.67; 95% CI 2.53-8.62; p = 8.0×10(-7)).

rs1047964 in BACE1;RNF214 gene and Pseudocholinesterase Measurement PMID 21779381 2011 Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.