Gene: BAD

Alternate names for this Gene: BBC2|BCL2L8

Gene Summary: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Gene is located in Chromosome: 11

Location in Chromosome : 11q13.1

Description of this Gene: BCL2 associated agonist of cell death

Type of Gene: protein-coding

Gene: GPR137

Alternate names for this Gene: C11orf4|GPR137A|TM7SF1L1

Gene Summary:

Gene is located in Chromosome: 11

Location in Chromosome : 11q13.1

Description of this Gene: G protein-coupled receptor 137

Type of Gene: protein-coding

rs34292685 in BAD;GPR137 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs477895 in BAD;GPR137 gene and Platelet Count measurement PMID 22423221 2012 The novel genetic variants associated with platelet count were in the following regions (the most significant SNP, closest gene, and p-value): 6p22 (rs12526480, LRRC16A, p = 9.1×10(-9)), 7q11 (rs13236689, CD36, p = 2.8×10(-9)), 10q21 (rs7896518, JMJD1C, p = 2.3×10(-12)), 11q13 (rs477895, BAD, p = 4.9×10(-8)), and 20q13 (rs151361, SLMO2, p = 9.4×10(-9)).

rs477895 in BAD;GPR137 gene and Platelet mean volume determination (procedure) PMID 22423221 2012 A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.