Gene: BAIAP2

Alternate names for this Gene: BAP2|FLAF3|IRSP53|WAML

Gene Summary: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene is located in Chromosome: 17

Location in Chromosome : 17q25.3

Description of this Gene: BAR/IMD domain containing adaptor protein 2

Type of Gene: protein-coding

rs140721383 in BAIAP2 gene and Arthritis, Gouty PMID 25676789 2015 Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.

rs140721383 in BAIAP2 gene and Gout PMID 25676789 2015 Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.

rs4969374 in BAIAP2 gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

rs55748329 in BAIAP2 gene and Major Depressive Disorder PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs8067235 in BAIAP2 gene and Memory performance PMID 24392092 2014 BAIAP2 is related to emotional modulation of human memory strength.

rs7502590 in BAIAP2 gene and Mood Disorders PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs140721383 in BAIAP2 gene and Uric acid measurement (procedure) PMID 25676789 2015 Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.

rs7502214 in BAIAP2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.