Gene: BCAR4

Alternate names for this Gene: -

Gene Summary: This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified.

Gene is located in Chromosome: 16

Location in Chromosome : 16p13.13

Description of this Gene: breast cancer anti-estrogen resistance 4

Type of Gene: ncRNA