Gene: BCO2

Alternate names for this Gene: B-DIOX-II|BCDO2

Gene Summary: This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11q23.1

Description of this Gene: beta-carotene oxygenase 2

Type of Gene: protein-coding

rs10891343 in BCO2 gene and C-reactive protein measurement PMID 24182552 2014 Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.

rs7105056 in BCO2 gene and Cytokine Measurement PMID 22610502 2012 Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.

rs11214136 in BCO2 gene and Epilepsy PMID 30868120 2019 A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.

rs2250417 in BCO2 gene and Interleukin 1 Beta Measurement PMID 24182552 2014 Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.

rs10891343 in BCO2 gene and Interleukin 18 Measurement PMID 20150558 2010 Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels.

PMID 20150558 2010 Forward selection analysis indicated that SNPs rs2115763 and rs1834481 were independently associated with IL-18 levels (P=0.0002 and 0.0006, respectively).

PMID 18464913 2008 A genome-wide association study identifies protein quantitative trait loci (pQTLs).

PMID 23696881 2013 Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.

rs2250417 in BCO2 gene and Protein measurement PMID 23696881 2013 Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.